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Acknowledgements
We thank Reiko Satoh and Yuko Yamanaka for their technical assistance. This study was supported partly by
the Japan Agency for Medical Research and Development (grant number JP20ak0101099; H.A. and H.K.), the
Kyoto University Foundation (H.A.), and the Takeda Science Foundation (H.A.).
Author contributions
H.A. and K.T. designed the research; H.A. conducted the experiments; T.I. and S.N. provided biological materials;
all authors analyzed the results; H.A. wrote the manuscript; all authors reviewed the manuscript.
Competing interests The authors declare no competing interests.
Additional information
Supplementary Information The online version contains supplementary material available at https://doi.org/
10.1038/s41598-021-98855-3.
Correspondence and requests for materials should be addressed to H.A. or K.T.
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