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大学・研究所にある論文を検索できる 「Clinical efficacy of the combined treatment of anti-PD-L1 rat-bovine chimeric antibody with a COX-2 inhibitor in calves infected with Mycoplasma bovis」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。
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Clinical efficacy of the combined treatment of anti-PD-L1 rat-bovine chimeric antibody with a COX-2 inhibitor in calves infected with Mycoplasma bovis

Shinya, Goto Satoru, Konnai Yuki, Hirano Junko, Kohara Tomohiro, Okagawa Naoya, Maekawa Yamato, Sajiki Kei, Watari Erina, Minato Atsuhi, Kobayashi Satoshi, Gondaira Hidetoshi, Higuchi Masateru, Koiwa Motoshi, Tajima Eiji, Taguchi Masaru, Ishida Ryoko, Uemura Shinji, Yamada Mika, K. Kaneko Yukinari, Kato Keiichi, Yamamoto Mikihiro, Toda Yasuhiko, Suzuki Shiro, Murata Kazuhiko, Ohashi 北海道大学

2020.05

概要

Mycoplasma bovis (M. bovis) is a highly contagious pathogen and M. bovis-associated diseases, particularly pneumonia, occur predominantly as herd enzootics, causing considerable economic losses because of calf mortality, weight loss in surviving calves. In our previous studies, the programmed death-1 (PD-1)/ PD-ligand 1 (PD-L1) pathway and prostaglandin E2 (PGE2) were shown to be involved in the immunosuppression during chronic infectious diseases in cattle. In this study, the efficacy of dual blockade of the PD-1/PD-L1 pathway and PGE2 in M. bovis infection in vivo was investigated using anti-bovine PD- L1 rat-bovine chimeric antibody, Boch4G12, and cyclooxygenase 2 (COX-2) inhibitor, meloxicam. The calves treated with Boch4G12 and meloxicam significantly enhanced M. bovis-specific IFN-γ response after the administration. On the other hand, IFN-γ response was not activated in the controls and cattle treated with meloxicam alone throughout the experimental period. Interestingly, bacterial loads in nasal discharge and bronchoalveolar lavage fluid among calves treated with Boch4G12 with or without meloxicam were significantly decreased. These results suggest that the combination of anti-PD-L1 antibody with a COX-2 inhibitor is a candidate for therapeutic applications in calves infected with M. bovis.

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