Treatment Strategy for Pancreatic Neuroendocrine Neoplasms (pNEN)

1） Japan NeuroEndocrine Tumor Society (JNETS) : Clinical Practice Guidelines for Gastroenteropancreatic Neuroendo­

crine Neoplasms (GEP-NEN) 2019

2） NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®

) Neuroendocrine and Adrenal Tumors Version

1.2019-March 5, 2019

3） Falconi M, Eriksson B, Kaltsas G, et al : ENETS Consensus Guidelines Update for the Management of Patients with

Functional Pancreatic Neuroendocrine Tumors and Non-Functional Pancreatic Neuroendocrine Tumors. Neuroendo­

crinology 103 : 153-171, 2016

4） Metz DC, Jensen RT : Gastrointestinal neuroendocrine tumors : pancreatic endocrine tumors. Gastroenterology 135 :

1469-1492, 2008

5） Vanderveen K, Grant C : Insulinoma. Cancer Treat Res 153 : 235-252, 2010

6）

Hirshberg B, Cochran C, Skarulis MC, et al : Malignant insulinoma : spectrum of unusual clinical features. Cancer

104 : 264-272, 2005

7）

Roldo C, Missiaglia E, Hagan JP, et al : MicroRNA expression abnormalities in pancreatic endocrine and acinar

tumors are associated with distinctive pathologic features and clinical behavior. J Clin Oncol 24 : 4677-4684, 2006

8） Jensen RT, Berna MJ, Bingham DB, et al : Inherited pancreatic endocrine tumor syndromes : advances in molecular

pathogenesis, diagnosis, management, and controversies. Cancer 113 : 1807-1843, 2008

9） Fendrich V, Waldmann J, Bartsch DK, et al : Surgical management of pancreatic endocrine tumors. Nat Rev Clin

Oncol 6 : 419-428, 2009

10） Mehrabi A, Fischer L, Hafezi M, et al : A systematic review of localization, surgical treatment options, and outcome

240

Shinshu Med J Vol. 68

Treatment strategy for pancreatic neuroendocrine neoplasms (pNEN)

of insulinoma. Pancreas 43 : 675-686, 2014

11） Guo Q, Wu Y : Surgical treatment of pancreatic islet cell tumor : report of 44 cases. Hepatogastroenterology 60 :

2099-2102, 2013

12） Knigge U, Hansen CP : Surgery for GEP-NETs. Best Pract Res Clin Gastroenterol 26 : 819-831, 2012

13） Sugiyama Y, Kiuchi C, Suzuki M, et al : Glucose Management during Insulinoma Resection Using Real-Time Subcu­

taneous Continuous Glucose Monitoring. Case Rep Anesthesiol 2018 : 6248467, 2018

14） Tonelli F, Giudici F, Nesi G, et al : Operation for insulinomas in multiple endocrine neoplasia type 1 : When pancre­

atoduodenectomy is appropriate. Surgery 161 : 727-734, 2017

15）

Bartsch DK, Waldmann J, Fendrich V, et al : Impact of lymphadenectomy on survival after surgery for sporadic

gastrinoma. Br J Surg 99 : 1234-1240, 2012

16）

Giovinazzo F, Butturini G, Monsellato D, et al : Lymph nodes metastasis and recurrences justify an aggressive treatment of gastrinoma. Updates Surg 65 : 19-24, 2013

17） Howard TJ, Stabile BE, Zinner MJ, et al : Anatomic distribution of pancreatic endocrine tumors. Am J Surg 159 :

258-264, 1990

18） Wu PC, Alexander HR, Bartlett DL, et al : A prospective analysis of the frequency, location, and curability of ectopic

(nonpancreaticoduodenal, nonnodal) gastrinoma. Surgery 122 : 1176-1182, 1997

19） Ito T, Igarashi H, Jensen RT : Pancreatic neuroendocrine tumors : clinical features, diagnosis and medical treat­

ment : advances. Best Pract Res Clin Gastroenterol 26 : 737-753, 2012

20）

Ito T, Igarashi H, Uehara H, et al : Pharmacotherapy of Zollinger-Ellison syndrome. Expert Opin Pharmacother

14 : 307-321, 2013

21） Imamura M, Komoto I, Ota S, et al : Biochemically curative surgery for gastrinoma in multiple endocrine neoplasia

type 1 patients. World J Gastroenterol 17 : 1343-1353, 2011

22） Bartsch DK, Fendrich V, Langer P, et al : Outcome of duodenopancreatic resections in patients with multiple endo­

crine neoplasia type 1. Ann Surg 242 : 757-764, discussion 764-756, 2005

23） Oberg K : Pancreatic endocrine tumors. Semin Oncol 37 : 594-618, 2010

24） Sadot E, Reidy-Lagunes DL, Tang LH, et al : Observation versus Resection for Small Asymptomatic Pancreatic Neu­

roendocrine Tumors : A Matched Case-Control Study. Ann Surg Oncol 23 : 1361-1370, 2016

25） Sallinen V, Haglund C, Seppanen H : Outcomes of resected nonfunctional pancreatic neuroendocrine tumors : Do size

and symptoms matter ? Surgery 158 : 1556-1563, 2015

26）

Tsutsumi K, Ohtsuka T, Mori Y, et al : Analysis of lymph node metastasis in pancreatic neuroendocrine tumors

(PNETs) based on the tumor size and hormonal production. J Gastroenterol 47 : 678-685, 2012

27） Partelli S, Gaujoux S, Boninsegna L, et al : Pattern and clinical predictors of lymph node involvement in nonfunction­

ing pancreatic neuroendocrine tumors (NF-PanNETs). JAMA Surg 148 : 932-939, 2013

28）

Furukori M, Imai K, Karasaki H, et al : Clinicopathological features of small nonfunctioning pancreatic neuroendo­

crine tumors. World J Gastroenterol 20 : 17949-17954, 2014

29） Gratian L, Pura J, Dinan M, et al : Impact of extent of surgery on survival in patients with small nonfunctional pan­

creatic neuroendocrine tumors in the United States. Ann Surg Oncol 21 : 3515-3521, 2014

30） Sorbye H, Welin S, Langer SW, et al : Predictive and prognostic factors for treatment and survival in 305 patients

with advanced gastrointestinal neuroendocrine carcinoma (WHO G3) : the NORDIC NEC study. Ann Oncol 24 : 152160, 2013

31） Hijioka S, Hosoda W, Matsuo K, et al : Rb Loss and KRAS Mutation Are Predictors of the Response to PlatinumBased Chemotherapy in Pancreatic Neuroendocrine Neoplasm with Grade 3 : A Japanese Multicenter Pancreatic

NEN-G3 Study. Clin Cancer Res 23 : 4625-4632, 2017

32） Hijioka S, Hosoda W, Mizuno N, et al : Does the WHO 2010 classification of pancreatic neuroendocrine neoplasms

No. 5, 2020

241

Kubota・Shimizu・Notake et al.

accurately characterize pancreatic neuroendocrine carcinomas ? J Gastroenterol 50 : 564-572, 2015

33） Dasari A, Shen C, Halperin D, et al : Trends in the Incidence, Prevalence, and Survival Outcomes in Patients With

Neuroendocrine Tumors in the United States. JAMA Oncol 3 : 1335-1342, 2017

34） Haugvik SP, Janson ET, Österlund P, et al : Surgical Treatment as a Principle for Patients with High-Grade Pancre­

atic Neuroendocrine Carcinoma : A Nordic Multicenter Comparative Study. Ann Surg Oncol 23 : 1721-1728, 2016

35） Han X, Xu X, Ma H, et al : Clinical relevance of different WHO grade 3 pancreatic neuroendocrine neoplasms based

on morphology. Endocr Connect 7 : 355-363, 2018

36） Hill JS, McPhee JT, McDade TP, et al : Pancreatic neuroendocrine tumors : the impact of surgical resection on sur­

vival. Cancer 115 : 741-751, 2009

37） Zhang XF, Beal EW, Chakedis J, et al : Early Recurrence of Neuroendocrine Liver Metastasis After Curative Hepa­

tectomy : Risk Factors, Prognosis, and Treatment. J Gastrointest Surg 21 : 1821-1830, 2017

38） Fendrich V, Langer P, Celik I, et al : An aggressive surgical approach leads to long-term survival in patients with

pancreatic endocrine tumors. Ann Surg 244 : 845-851 ; discussion 852-843, 2006

39） Cho CS, Labow DM, Tang L, et al : Histologic grade is correlated with outcome after resection of hepatic neuroendo­

crine neoplasms. Cancer 113 : 126-134, 2008

40）

Sarmiento JM, Que FG, Grant CS, et al : Concurrent resections of pancreatic islet cell cancers with synchronous

hepatic metastases : outcomes of an aggressive approach. Surgery 132 : 976-982 ; discussion 982-973, 2002

41）

De Jong MC, Farnell MB, Sclabas G, et al : Liver-directed therapy for hepatic metastases in patients undergoing

pancreaticoduodenectomy : a dual-center analysis. Ann Surg 252 : 142-148, 2010

42） Moris D, Tsilimigras DI, Ntanasis-Stathopoulos I, et al : Liver transplantation in patients with liver metastases from

neuroendocrine tumors : A systematic review. Surgery 162 : 525-536, 2017

（2020. 6. 9 received） 242

Shinshu Med J Vol. 68

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