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Combining Multiple Indices of Diffusion Tensor Imaging Can Better Differentiate Patients with Traumatic Brain Injury from Healthy Subjects

Abdelrahman, Hiba Abuelgasim Fadlelmoula 京都大学 DOI:10.14989/doctor.k24512

2023.03.23

概要

Traumatic brain injury (TBI) is a common cause of mortality and morbidity worldwide.1 Individuals with TBI have an
elevated risk of developing numerous neurocognitive and psychiatric illnesses.2,3 Diffuse axonal injury (DAI) is one of
the most common and important pathological features of TBI.4,5 DAI following TBI occurs as a result of acceleration/
deceleration trauma to the brain, which can result in the shearing and disruption of white matter axons.6,7 DAI may
include extensive microscopic axonal damage, even in the absence of abnormal findings on conventional computed
tomography (CT) and magnetic resonance imaging (MRI).8 Unlike conventional imaging techniques, diffusion tensor
imaging (DTI) can be used to identify and quantify white matter microstructural changes following DAI.9–12 DTI is
therefore considered to be one of the most promising techniques for the study and diagnosis of DAI following TBI.
DTI measures the directional coherence of water diffusion along white matter axons.13,14 A variety of parameters can
be obtained from a DTI scan (DTI indices), including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity
(AD), and radial diffusivity (RD). DTI indices reflect the integrity of white matter microstructures. ...

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