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大学・研究所にある論文を検索できる 「Preparation of hyaluronic acid-coated polymeric micelles for nasal vaccine delivery」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。
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Preparation of hyaluronic acid-coated polymeric micelles for nasal vaccine delivery

Suzuki Kengo Yoshizaki Yuta Horii Kenta Murase Nobuo Kuzuya Akinori 00456154 0000-0003-0003-2996 Ohya Yuichi 10213886 0000-0002-8862-850X 関西大学 DOI:10.1039/d1bm01985f

2022.01.26

概要

Hyaluronic acid (HA)-coated biodegradable polymeric micelles were developed as nanoparticulate vaccine delivery systems to establish an effective nasal vaccine. We previously reported HA-coated micelles prepared by forming a polyion complex (PIC) of poly(L-lysine)-b-polylactide (PLys+-b-PLA) micelles and HA. The HA-coated micelles exhibited specific accumulation in HA receptor-expressing cells and extremely high colloidal stability under diluted blood conditions. In this study, a model antigen, ovalbumin (OVA), and an adjuvant oligonucleotide containing the CG motif (CpG-DNA) were efficiently loaded in HA-coated micelles via electrostatic interactions. HA-coated micelles delivered OVA and CpG-DNA in mouse bone marrow- derived dendritic cells (BMDCs) and resulted in upregulation of mRNA encoding IFN-γ and IL-4 in BMDCs. In addition, HA- coated micelles enhanced the expression of the major histocompatibility complex (MHC) class II on BMDCs. We investigated the immune response of HA-coated micelles following intranasal administration. HA-coated micelles induced higher OVA- specific IgG in the blood and OVA-specific IgA in the nasal wash than control (carboxymethyl dextran-coated) micelles. These results suggest that HA-coated micelles efficiently deliver antigens and adjuvants to mucosal-resident immune cells. Therefore, HA-coated micelles are promising platforms for developing nasal vaccines against infectious diseases.

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参考文献

1 J. R. Teijaro and D. L. Farber, Nat. Rev. Immunol., 2021, 21, 195-197.

2 E. Bettini, M. Locci, Vaccines., 2021, 9, 147.

3 A. J. Macpherson, M. B. Geuking and K. D. McCoy, Trends. Immunol., 2012, 33, 160-167.

4 S. Al-Halifa, L. Gauthier, D. Arpin, S. Bourgault and D. Archambault, Front. Immunol., 2019, 10, 22.

5 B. Bernocchi, R. Carpentier and D. Betbeder, Int. J. Pharm., 2017, 530, 128-138.

6 A. R. Khan, M. R. Liu, M. W. Khan and G. X. Zhai, J. Control Release, 2017, 268, 364-389.

7 A. C. Anselmo, Y. Gokarn and S. Mitragotri, Nat. Rev. Drug Discov., 2019, 18, 19-40.

8 L. Illum, J. Control Release, 2003, 87, 187-198.

9 S. Mitragotri, Nat. Rev. Immunol., 2005, 5, 905-916.

10 H. Hasegawa, S. Kadowaki, H. Takahashi, T. Iwasaki, S. Tamura and T. Kurata, Vaccine, 2000, 18, 2560-2565.

11 S. N. Georas and F. Rezaee, J. Allergy. Clin. Immunol., 2014,134, 509-520.

12 S. Y. Chang, H. Y. Ko and M. N. Kweon, Exp. Mol. Med., 2014,46, e84.

13 S. Singha, K. Shao, K. K. Ellestad, Y. Yang and P. Santamaria,ACS Nano, 2018, 12, 10621-10635.

14 M. R. Neutra and P. A. Kozlowski, Nat. Rev. Immunol., 2006, 6, 148-158.

15 A. J. Almeida and E. Souto, Adv. Drug. Deliv. Rev., 2007, 59, 478-490.

16 L. J. Peek, C. R. Middaugh and C. Berkland, Adv. Drug. Deliv.Rev., 2008, 60, 915-928.

17 C. A. Garcia-Gonzalez, A. Sosnik, J. Kalmar, I. De Marco, C. Erkey, A. Concheiro and C. Alvarez-Lorenzo, J. Control Release, 2021, 332, 40-63.

18 J. D. Pachioni-Vasconcelos, A. M. Lopes, A. C. Apolinario, J. K. Valenzuela-Oses, J. S. R. Costa, L. D. Nascimento, A. Pessoa, L.R. S. Barbosa and C. D. Rangel-Yagui, Biomater. Sci., 2016, 4. 205-218.

19 P. M. Lackie, J. E. Baker, U. Günthert and S. T. Holgate, Am. J. Respir. Cell. Mol. Biol., 1997, 16, 14-22.

20 A. Mero and M. Campisi, Polymers, 2014, 6, 346-369.

21 D. H. Jiang, J. R. Liang and P. W. Noble, Physiol. Rev., 2011, 91, 221-264.

22 R. J. Verheul, B. Slutter, S. M. Bal, J. A. Bouwstra, W. Jiskoot and W. E. Hennink, J. Control. Release, 2011, 156, 46-52.

23 L. X. Liu, F. Q. Cao, X. X. Liu, H. Wang, C. Zhang, H. F. Sun, C.Wang, X. G. Leng, C. X. Song, D. L. Kong and G. L. Ma, Appl. Mater. Interfaces, 2016, 8, 11969-11979.

24 L. Illum, N. F. Farraj, A. N. Fisher, I. Gill, M. Miglietta and L. M. Benedetti, J. Control. Release, 1994, 29, 133-141.

25 M. Singh, M. Briones and D. T. O'Hagan, J. Control. Release, 2001, 70, 267-276.

26 Y. C. Fan, P. Sahdev, L. J. Ochyl, J. J. Akerberg and J. J. Moon, J. Control. Release, 2015, 208, 121-129.

27 K. Pritchard, A. B. Lansley, G. P. Martin, M. Helliwell, C. Marriott and L. M. Benedetti, Int. J. Pharm., 1996, 129, 137- 145.

28 K. Kataoka, A. Harada and Y. Nagasaki, Adv. Drug. Deliv. Rev., 2001, 47, 113-131.

29 H. Cabral, K. Miyata, K. Osada and K. Kataoka, Chem. Rev., 2018, 118, 6844-6892.

30 A. Mandal, R. Bisht, I. D. Rupenthal and A. K. Mitra, J. Control Release, 2017, 248, 96-116.

31 S. H. S Leung and J. R. Robinson, J. Control Release, 1987, 5, 223-231.

32 R. Sharma, U. Agrawal, N. Mody and S. P. Vyas, Biotechnol.Adv., 2015, 33, 64-79.

33 W. J. Fan, L. Liu and H. Y. Zhao, Angew. Chem. Int. Ed., 2017,56, 8844-8848.

34 H. S. Min, H. J. Kim, J. Ahn, M. Naito, K. Hayashi, K. Toh, BS. Kim, Y. Matsumura, I. C. Kwon, K. Miyata and K. Kataoka, Biomacromolecules, 2018, 19, 2320-2329.

35 Y. T. Wang, L. P. Huang, Y. Shen, L. D. Tang, R. N. Sun, D. Shi,T. J. Webster, J. S. Tu and C. M. Sun, Int. J. Nanomedicine, 2017,12, 7963-7977.

36 Y. Ohya, S. Takeda, Y. Shibata, T. Ouchi and A. Maruyama,Macromol. Chem. Phys., 2010, 211, 1750-1756.

37 Y. Ohya, S. Takeda, Y. Shibata, T. Ouchi, A. Kano, T. Iwata, S. Mochizuki, Y. Taniwaki and A. Maruyama, J. Control. Release, 2011, 155, 104-110.

38 M. J. McCluskie, R. D. Weeratna and H. L. Davis, Mol. Med., 2000, 6, 867-877.

39 E. Yuba, A. Harada, Y. Sakanishi, S. Watarai and K. Kono,Biomaterials., 2013, 34, 3042-3052.

40 Y. Yoshizaki, E. Yuba, N. Sakaguchi, K. Koiwai, A. Harada and K. Kono, Biomaterials., 2017, 141, 272-283.

41 J. J. Varghese, I. L. Schmale, M. E. Hansen, S. D. Newlands, D.S. W. Benoit and C. E. Ovitt, J. Vis. Exp., 2018, 135, e57522.

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