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23
Figure 1
A 3D -rotational angiography
3D-casted mold
CD31 VE-Cadherin DAPI
Primary
antibody (-)
Culture of HUAECs on the surface E
before
after
Merged
0 50 100 150 200
PC1: 89 % variance
-50
60
Aneurysm
Artery
20
Aneurysm 1
Aneurysm 2
Aneurysm 4
Aneurysm 3
Aneurysm 5
Artery 2
Artery 1
Artery 3
40
PC2: 7 % variance
Figure 2
NDUFA4
RAN
SAT1
YWHAE
COL4A1
CALR
EPAS1
PDGFB
HSPB1
HSP90B1
LMNA
HSPD1
VIM
RPL10A
YBX3
HSPA5
RAB7A
NDUFV2
EIF4H
EIF4A1
CALM1
PPP1R14B
PFN1
RPL23
NR3C1
ATP1A1
BRI3
RPS18
CLTA
YWHAQ
DNAJVB1
CAP1
NAA50
VEGFA
ETS1
MAGED2
Figure 3
Day 0
EC
Day 14
EC
EC
Figure 4
Intracranial Superficial
aneurysm temporal
artery
CD31
DAPI
Merged
Intracranial
aneurysm
Superficial
temporal
artery
DAPI
Merged
DAPI
Primary
antibody
(-)
DAPI
Superficial
Intracranial
temporal
aneurysm
artery
Primary
antibody
(-)
Phosphorated-eNOS
DAPI
Merged
DAPI
VE-cadherin
Primary
antibody
(-)
Table 1. Down-represented terms in gene ontology analysis (Biological Process).
GO term
P-value
Cellular response to stress
2.60E-08
Establishment of localization in cell
1.30E-07
Cellular macromolecule catabolic process
1.30E-06
Intracellular transport
1.50E-06
Macromolecule catabolic process
2.80E-06
Cellular protein-containing complex assembly
2.80E-06
Protein-containing complex subunit organization
2.80E-06
MRNA metabolic process
5.30E-06
Ubiquitin-dependent protein catabolic process
7.60E-06
Apoptotic process
7.60E-06
Response to organic substance
7.60E-06
Protein catabolic process
7.60E-06
Modification-dependent macromolecule catabolic process
8.80E-06
Modification-dependent protein catabolic process
1.10E-05
Proteasomal protein catabolic process
1.20E-05
Table 2. Down-represented terms in gene ontology analysis (Cellular Component).
Go term
P-value
Nucleoplasm
4.60E-10
Nuclear lumen
4.50E-09
Vesicle
1.10E-07
Extracellular exosome
1.10E-07
Extracellular organelle
1.50E-07
Inner mitochondrial membrane protein complex
7.20E-07
Respiratory chain complex
3.60E-06
Mitochondrial respirasome
5.40E-06
Catalytic complex
9.70E-06
Mitochondrial protein-containing complex
1.10E-05
Organelle membrane
1.70E-05
Organelle envelope
2.00E-05
Respirasome
2.00E-05
Table 3. Down-represented terms in gene ontology analysis (Molecular Function).
Go term
P-value
RNA binding
1.00E-08
Enzyme binding
3.40E-06
Cadherin binding
7.90E-06
Nucleic acid binding
8.40E-05
NAD(P)H dehydrogenase (quinone) activity
2.00E-04
Electron transfer activity
2.00E-04
NADH dehydrogenase activity
2.40E-04
Oxidoreductase activity, acting on NAD(P)H, quinone or
2.40E-04
similar compound as acceptor
NADH dehydrogenase (quinone) activity
2.40E-04
NADH dehydrogenase (ubiquinone) activity
6.80E-04
Cell adhesion molecule binding
6.80E-04
Proton transmembrane transporter activity
7.30E-04
Oxidoreductase activity, acting on NAD(P)H
8.10E-04
ATPase activity, coupled to transmembrane movement of
4.00E-03
ions, rotational mechanism
...
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