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131
注釈
本研究は、複数の共同研究者とともに行われた。特に、研究の進行や得
られた実験結果の解析及び解釈については、服部佑佳子博士と上村匡教授と議論を
重ねて方針を吟味した。本論文の実験データの大部分を自らが取得したが、以下の
実験には共同研究者が寄与している。図 48, 49B の RNA-seq 解析では、渡辺佳織博
士がサンプル調製を行い、服部佑佳子博士がデータ解析を行った。図 58 では、小野
寺孝興博士が電気生理実験を行った。また、図 46A, B の C3da neuron の画像は林優
作氏が取得した。
132
謝辞
学部の卒業研究生として上村研に加わってからこれまで約７年間、上村匡教授と服
部佑佳子助教には、特にお世話になりました。日々の研究では、得たデータについ
て綿密に議論をした上で、数々の助言をいただきました。また、実験手法やデータ
解析だけでなく、文書作成や学会発表の準備など、研究生活で必須のノウハウを熱
心にご指導いただきました。お二方から教えていただいたことは、研究に限らず、
私がこれからのキャリアを歩んで様々な仕事をする上でも活きていくと思います。
心よりお礼申し上げます。また、渡辺佳織博士には、ショウジョウバエの飼育方法
から分子生物学的な実験手法に至るまで、数多くの指導をしていただきました。碓
井理夫講師や小野寺孝興博士には本研究（特に電気生理学的解析に関わる実験）に
関して、多くの協力、助言をしていただき、参考となる文献も教えていただきまし
た。また、他の上村研究室のメンバーの方々にも、ラボミーティングにおいて大変
有意義なコメントや助言をいただきました。二股真由美さんには、ショウジョウバ
エの
作りをはじめとする実験補助をしていただきました。また、秘書の沖かなえ
さん、森口良子さん、今井博子さんには事務手続きを補助していただきました。お
かげさまで円滑に研究を進めることができました。以上の上村研究室の方々の助け
があってこそ、ここまで研究を続けることができました。本当にありがとうござい
ました。
本研究の遂行にあたってお世話になった方々にも感謝申し上げます。京都大
学大学院生命科学研究科の James A. Hejna 教授と京都大学ヒト生物学高等研究拠点の
Spyros Goulas 講師には、根拠論文の英文校正をしていただきました。京都大学大学
院生命科学研究科の近藤武史助教と山銅ゆかりさんには、ライブラリ調製などを含
めた RNA-seq 解析を行って頂きました。カリフォルニア大学リバーサイド校の山中
直岐准教授には Light/dark choice assay の実験方法を丁寧に教えていただきました。
また、筑波大学の丹羽隆介教授、島田裕子助教、岡本直樹助教には、ショウジョウ
バエ幼虫の成長速度を操作する方法を教えていただきました。京都大学大学院生命
科学研究科の神戸大朋准教授にも本研究についてご議論いただき、栄養素の知識を
133
ご教授いただきました。The Pennsylvania State University の Dr. Melissa Rolls、Curie
Institute の Dr. Pierre Leopold と佐奈喜裕哉博士、京都大学大学院生命科学研究科の井
垣達吏教授、榎本将人助教、井藤喬夫博士、中村麻衣博士、群馬大学の西村隆史教
授、秋田大学の山崎正和准教授、金沢大学の佐藤純教授には、ショウジョウバエ系
統を分与して頂きました。この他にも、京都工芸繊維大学ショウジョウバエ遺伝資
源センター、国立遺伝学研究所、Bloomington Drosophila Stock Center、Vienna
Drosophila RNAi Center からショウジョウバエの系統を、Developmental Studies
Hybridoma Bank には抗体を供与していただいた他、研究ツールや先行研究の日々の
情報収集には、Flybase を活用させていただきました。また、令和 2 年 4 月から令和
4 年 3 月まで日本学術振興会の特別研究員 DC2 として研究に従事させていただきま
した。心より感謝申し上げます。
最後に、これまで私の研究生活を温かく見守り、支えてくださった家族や友
人に厚くお礼申し上げます。
本学位論文は以下の学術論文の内容に基づいて書かれたものです。
Yasutetsu Kanaoka, Koun Onodera, Kaori Watanabe, Yusaku Hayashi, Tadao Usui, Tadashi
Uemura, and Yukako Hattori
Inter-organ Wingless/Ror/Akt signaling regulates nutrient-dependent hyperarborization of
somatosensory neurons.
eLife, 12:e79461, 2023. doi:10.7554/eLife.79461
金岡
泰哲
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論文の公開元へ
