リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

大学・研究所にある論文を検索できる 「Clinical impact of spacer placement surgery with expanded polytetrafluoroethylene sheet for particle therapy」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

コピーが完了しました

URLをコピーしました

論文の公開元へ論文の公開元へ
書き出し

Clinical impact of spacer placement surgery with expanded polytetrafluoroethylene sheet for particle therapy

Fujinaka, Ryosuke Komatsu, Shohei Terashima, Kazuki Demizu, Yusuke Omiya, Satoshi Kido, Masahiro Toyama, Hirochika Tokumaru, Sunao Okimoto, Tomoaki Fukumoto, Takumi 神戸大学

2023.10.24

概要

Background: Spacer placement surgery is useful in particle therapy (PT) for patients with abdominopelvic malignant tumors located adjacent to the gastrointestinal tract. This study aimed to assess the safety, efficacy, and long-term outcomes of spacer placement surgery using an expanded polytetrafluoroethylene (ePTFE) spacer. Methods: This study included 131 patients who underwent ePTFE spacer placement surgery and subsequent PT between September 2006 and June 2019. The overall survival (OS) and local control (LC) rates were calculated using Kaplan-Meier method. Spacer-related complications were classified according to the National Cancer Institute Common Terminology Criteria for Adverse Events (version 5.0). Results: The median follow-up period after spacer placement surgery was 36.8 months. The 3-year estimated OS and LC rates were 60.5% and 76.5%, respectively. A total of 130 patients (99.2%) were able to complete PT. Spacer-related complications of ≥ grade 3 were observed in four patients (3.1%) in the acute phase and 13 patients (9.9%) in the late phase. Ten patients (7.6%) required removal of the ePTFE spacer. Conclusions: Spacer placement surgery using an ePTFE spacer for abdominopelvic malignant tumors is technically feasible and acceptable for subsequent PT. However, severe spacer-related late complications were observed in some patients. Since long-term placement of a non-absorbable ePTFE spacer is associated with risks for morbidity and infection, careful long-term follow-up and prompt therapeutic intervention are essential when complications associated with the ePTFE spacer occur. Trial registration: retrospectively registered.

この論文で使われている画像

参考文献

1. Gerweck LE, Kozin SV. Relative biological effectiveness of proton beams in

clinical therapy. Radiother Oncol. 1999;50:135–42.

2. Paganetti H, Niemierko A, Ancukiewicz M, Gerweck LE, Goitein M, Loeffler JS,

et al. Relative biological effectiveness (RBE) values for proton beam therapy.

Int J Radiat Oncol Biol Phys. 2002;53:407–21.

3. Brada M, Pijls-Johannesma M, De Ruysscher D. Proton therapy in clinical

practice: current clinical evidence. J Clin Oncol. 2007;25:965–70.

4. Demizu Y, Jin D, Sulaiman NS, Nagano F, Terashima K, Tokumaru S, et al. Particle therapy using protons or Carbon ions for Unresectable or incompletely

resected bone and soft tissue sarcomas of the Pelvis. Int J Radiat Oncol Biol

Phys. 2017;98:367–74.

5. Iwata H, Murakami M, Demizu Y, Miyawaki D, Terashima K, Niwa Y, et al. Highdose proton therapy and carbon-ion therapy for stage I nonsmall cell Lung

cancer. Cancer. 2010;116:2476–85.

6. Schulz-Ertner D, Tsujii H. Particle radiation therapy using proton and heavier

ion beams. J Clin Oncol. 2007;25:953–64.

7. Gaito S, Hwang EJ, France A, Aznar MC, Burnet N, Crellin A, et al. Outcomes

of patients treated in the UK Proton Overseas Programme: Central Nervous

System Group. Clin Oncol (R Coll Radiol). 2023;35:283–91.

8. Hwang E, Gaito S, France A, Crellin AM, Thwaites DI, Ahern V, et al. Outcomes

of patients treated in the UK Proton Overseas Programme: non-central

nervous System Group. Clin Oncol (R Coll Radiol). 2023;35:292–300.

24. 25. 26. 27. 28. 29. 30. 31. Ishikawa H, Tsuji H, Kamada T, Hirasawa N, Yanagi T, Mizoe JE, et al. Risk factors

of late rectal bleeding after carbon ion therapy for Prostate cancer. Int J

Radiat Oncol Biol Phys. 2006;66:1084–91.

Komatsu S, Murakami M, Fukumoto T, Hori Y, Hishikawa Y, Ku Y. Risk factors

for survival and local recurrence after particle radiotherapy for single small

hepatocellular carcinoma. Br J Surg. 2011;98:558–64.

Fukumoto T, Komatsu S, Hori Y, Murakami M, Hishikawa Y, Ku Y. Particle beam

radiotherapy with a surgical spacer placement for advanced abdominal

leiomyosarcoma results in a significant clinical benefit. J Surg Oncol.

2010;101:97–9.

Hashimoto Y, Komatsu S, Terashima K, Tsugawa D, Yanagimoto H, Suga M,

et al. Space-making particle therapy for Unresectable Hilar Cholangiocarcinoma. Dig Surg. 2022;39:99–108.

Komatsu S, Demizu Y, Sulaiman NS, Terashima K, Suga M, Kido M, et al. Spacemaking particle therapy for sarcomas derived from the abdominopelvic

region. Radiother Oncol. 2020;146:194–9.

Komatsu S, Hori Y, Fukumoto T, Murakami M, Hishikawa Y, Ku Y. Surgical

spacer placement and proton radiotherapy for unresectable hepatocellular

carcinoma. World J Gastroenterol. 2010;16:1800–3.

Komatsu S, Terashima K, Matsuo Y, Takahashi D, Suga M, Nishimura N, et al.

Validation of combination treatment with surgical spacer placement and

subsequent particle radiotherapy for unresectable hepatocellular carcinoma.

J Surg Oncol. 2019;120:214–22.

Lee D, Komatsu S, Terashima K, Toyama H, Matsuo Y, Takahashi D, et al. Surgical spacer placement for proton radiotherapy in locally advanced pancreatic

body and tail cancers: initial clinical results. Radiat Oncol. 2021;16:3.

Tsugawa D, Komatsu S, Demizu Y, Sulaiman NS, Suga M, Kido M, et al. Spacemaking particle therapy with Surgical Spacer Placement in patients with

Sacral Chordoma. J Am Coll Surg. 2020;230:207–15.

Chung H, Polf J, Badiyan S, Biagioli M, Fernandez D, Latifi K, et al. Rectal dose

to Prostate cancer patients treated with proton therapy with or without

rectal spacer. J Appl Clin Med Phys. 2017;18:32–9.

Rucinski A, Brons S, Richter D, Habl G, Debus J, Bert C, et al. Ion therapy of

Prostate cancer: daily rectal dose reduction by application of spacer gel.

Radiat Oncol. 2015;10:56.

Lorenzo C, Andrea P, Barbara V, Denis P, Rosaria FM, Piero F, et al. Surgical

spacer placement prior carbon ion radiotherapy (CIRT): an effective feasible

strategy to improve the treatment for sacral chordoma. World J Surg Oncol.

2016;14:211.

Yoon SS, Chen YL, Kambadakone A, Schmidt B, DeLaney TF. Surgical placement of biologic mesh spacers prior to external beam radiation for retroperitoneal and pelvic tumors. Pract Radiat Oncol. 2013;3:199–208.

Minohara S, Kanai T, Endo M, Noda K, Kanazawa M. Respiratory gated

irradiation system for heavy-ion radiotherapy. Int J Radiat Oncol Biol Phys.

2000;47:1097–103.

Aibe N, Demizu Y, Sulaiman NS, Matsuo Y, Mima M, Nagano F, et al. Outcomes

of patients with primary sacral chordoma treated with definitive Proton

Beam Therapy. Int J Radiat Oncol Biol Phys. 2018;100:972–9.

Takagi M, Demizu Y, Terashima K, Fujii O, Jin D, Niwa Y, et al. Long-term outcomes in patients treated with proton therapy for localized Prostate cancer.

Cancer Med. 2017;6:2234–43.

Komatsu S, Fukumoto T, Demizu Y, Miyawaki D, Terashima K, Niwa Y, et al. The

effectiveness of particle radiotherapy for hepatocellular carcinoma associated

with inferior vena cava Tumor thrombus. J Gastroenterol. 2011;46:913–20.

Komatsu S, Fukumoto T, Demizu Y, Miyawaki D, Terashima K, Sasaki R, et al.

Clinical results and risk factors of proton and carbon ion therapy for hepatocellular carcinoma. Cancer. 2011;117:4890–904.

Kagawa K, Murakami M, Hishikawa Y, Abe M, Akagi T, Yanou T, et al. Preclinical

biological assessment of Proton and carbon ion beams at Hyogo Ion Beam

Medical Center. Int J Radiat Oncol Biol Phys. 2002;54:928–38.

Sezeur A, Martella L, Abbou C, Gallot D, Schlienger M, Vibert JF, et al. Small

intestine protection from radiation by means of a removable adapted prosthesis. Am J Surg. 1999;178:22–5.

Waddell BE, Lee RJ, Rodriguez-Bigas MA, Weber TK, Petrelli NJ. Absorbable mesh sling prevents radiation-induced bowel injury during sandwich

chemoradiation for rectal cancer. Arch Surg. 2000;135:1212–7.

Alongi F, Rigo M, Figlia V, Cuccia F, Giaj-Levra N, Nicosia L, et al. Rectal spacer

hydrogel in 1.5T MR-guided and daily adapted SBRT for Prostate cancer:

dosimetric analysis and preliminary patient-reported outcomes. Br J Radiol.

2021;94:20200848.

Cuccia F, Mazzola R, Nicosia L, Figlia V, Giaj-Levra N, Ricchetti F, et al. Impact

of hydrogel peri-rectal spacer insertion on prostate gland intra-fraction

Fujinaka et al. Radiation Oncology

32. 33. 34. 35. (2023) 18:173

motion during 1.5 T MR-guided stereotactic body radiotherapy. Radiat Oncol.

2020;15:178.

Ogino T, Sekimoto M, Nishimura J, Takemasa I, Mizushima T, Ikeda M, et al.

Intraluminal migration of a spacer with small bowel obstruction: a case

report of rare complication. World J Surg Oncol. 2012;10:30.

Shiba S, Okamoto M, Shibuya K, Okazaki S, Kobayashi D, Miyasaka Y, et al.

Safety and Efficacy of Re-irradiation with Carbon-ion Radiotherapy for Pelvic

recurrence of rectal Cancer after Preoperative Chemoradiotherapy: a retrospective analysis. Vivo. 2022;36:2473–80.

Sasaki R, Demizu Y, Yamashita T, Komatsu S, Akasaka H, Miyawaki D, et al.

First-In-Human phase 1 study of a Nonwoven Fabric Bioabsorbable Spacer

for particle therapy: space-making particle therapy (SMPT). Adv Radiat Oncol.

2019;4:729–37.

Akasaka H, Sasaki R, Miyawaki D, Mukumoto N, Sulaiman NS, Nagata M, et al.

Preclinical evaluation of bioabsorbable polyglycolic acid spacer for particle

therapy. Int J Radiat Oncol Biol Phys. 2014;90:1177–85.

Page 10 of 10

36. Shiba S, Okamoto M, Tashiro M, Ogawa H, Osone K, Yanagawa T, et al. Rectal

dose-sparing effect with bioabsorbable spacer placement in carbon ion

radiotherapy for sacral chordoma: dosimetric comparison of a simulation

study. J Radiat Res. 2021;62:549–55.

37. Yamamoto Y, Hino A, Kurihara H, Kano K, Serizawa I, Katoh H, et al. Transitional

changes of spacer materials used in carbon-ion radiation therapy. Asia Pac J

Clin Oncol. 2022;18:e442–7.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in

published maps and institutional affiliations.

...

参考文献をもっと見る

全国の大学の
卒論・修論・学位論文

一発検索!

この論文の関連論文を見る