1. Murakami S, Nakashima R, Yamashita E et al. Crystal structure of bacterial multidrug efflux transporter AcrB. Nature 2002; 419: 587-93.
2. Nishino K, Nikaido E, Yamaguchi A. Regulation and physiological function of multidrug efflux pumps in Escherichia coli and Salmonella. Biochim Biophys Acta 2009; 1794: 834-43.
3. Nishino K, Latifi T, Groisman EA. Virulence and drug resistance roles of multidrug efflux systems of Salmonella enterica serovar Typhimurium. Mol Microbiol. 2006; 59(1):126-41.
4. Horiyama T, Yamaguchi A, Nishino K. TolC dependency of multidrug efflux systems in Salmonella enterica serovar Typhimurium. J Antimicrob Chemother. 2010; 65(7):1372-6.
5. Nishino K and Yamaguchi A. Analysis of a complete library of putative drug transporter genes in Escherichia coli. J Bacteriol. 2001; 183(20):5803-12.
6. Poole K. Multidrug efflux pumps and antimicrobial resistance in Pseudomonas aeruginosa and related organisms. J Mol Microbiol Biotechnol. 2001; 3(2):255-64.
7. Ma D, Cook DN, Alberti M et al. Molecular cloning and characterization of acrA and acrE genes of Escherichia coli. J Bacteriol. 1993; 175(19):6299-313.
8. Zgurskaya HI and Nikaido H. Bypassing the periplasm: reconstitution of the AcrAB multidrug efflux pump of Escherichia coli. Proc Natl Acad Sci U S A. 1999; 96(13):7190-5.
9. Eswaran J, Hughes C, Koronakis V. Locking TolC entrance helices to prevent protein translocation by the bacterial type I export apparatus. J Mol Biol. 2003; 327(2):309-15.
10. Buckley AM, Webber MA, Cooles S et al. The AcrAB-TolC efflux system of Salmonella enterica serovar Typhimurium plays a role in pathogenesis. Cell Microbiol. 2006; 8(5):847-56
11. Webber MA, Bailey AM, Blair JM et al. The global consequence of disruption of the AcrAB-TolC efflux pump in Salmonella enterica includes reduced expression of SPI-1 and other attributes required to infect the host. J Bacteriol. 2009; 191(13):4276-85.
12. Blair JMA, Ragione RML, Woodward MJ et al. Periplasmic adaptor protein AcrA has a distinct role in the antibiotic resistance and virulence of Salmonella enterica serovar Typhimurium. J Antimicrob Chemother. 2009; 64(5):965-72.
13. Virlogeux-Payant I, Baucheron S, Pelet J et al. TolC, but not AcrB, is involved in the invasiveness of multidrug-resistant Salmonella enterica serovar Typhimurium by increasing type III secretion system-1 expression. Int J Med Microbiol. 2008; 298(7-8):561-9.
14. Baugh S, Ekanayaka AS, Piddock LJ et al. Loss of or inhibition of all multidrug resistance efflux pumps of Salmonella enterica serovar Typhimurium results in impaired ability to form a biofilm. J Antimicrob Chemother. 2012; 67(10):2409-17.
15. Baugh S, Phillips CR, Ekanayaka AS et al. Inhibition of multidrug efflux as a strategy to prevent biofilm formation. J Antimicrob Chemother. 2014; 69(3):673-81.
16. Blair JMA, Smith HE, Ricci V et al. Expression of homologous RND efflux pump genes is dependent upon AcrB expression: implications for efflux and virulence inhibitor design. J Antimicrob Chemother. 2015; 70(2):424-31.
17. Zhang C, Chen P, Yang L et al. Coordinated Expression of acrAB-tolC and Eight Other Functional Efflux Pumps Through Activating ramA and marA in Salmonella enterica serovar Typhimurium. Microb Drug Resist. 2018; 24(2):120-125.
18. Wang-Kan X, Blair JMA, Chirullo B et al. Lack of AcrB Efflux Function Confers Loss of Virulence on Salmonella enterica Serovar Typhimurium. MBio. 2017; 8(4). pii: e00968-17
19. Nikaido E, Shirosaka I, Yamaguchi Akihito et al. Regulation of the AcrAB multidrug efflux pump in Salmonella enterica serovar Typhimurium in response to indole and paraquat. Microbiology. 2011; 157(Pt 3):648-55.
20. Baucheron S, Nishino K, Monchaux I et al. Bile-mediated activation of the acrAB and tolC multidrug efflux genes occurs mainly through transcriptional derepression of ramA in Salmonella enterica serovar Typhimurium. J Antimicrob Chemother. 2014; 69(9):2400-6.
21. Nikaido E, Yamaguchi A, Nishino K. AcrAB multidrug efflux pump regulation in Salmonella enterica serovar Typhimurium by RamA in response to environmental signals. J Biol Chem. 2008; 283(35):24245-53.
22. Yamasaki S, Nagasawa S, Hayashi-Nishino M et al. AcrA dependency of the AcrD efflux pump in Salmonella enterica serovar Typhimurium. J Antibiot (Tokyo). 2011; 64(6):433-7.
23. Buckner MMC, Blair JMA, Ragione RML et al. Beyond Antimicrobial Resistance: Evidence for a Distinct Role of the AcrD Efflux Pump in Salmonella Biology. MBio. 2016; 7(6). pii: e01916-16.
24. Nishino K, Nikaido E, Yamaguchi A. Regulation of multidrug efflux systems involved in multidrug and metal resistance of Salmonella enterica serovar Typhimurium J Bacteriol. 2007; 189(24):9066-75.
25. Song S, Lee B, Yeom J et al. MdsABC-Mediated Pathway for Pathogenicity in Salmonella enterica Serovar Typhimurium. Infect Immun. 2015; 83(11):4266-76.
26. Pontel LB, Audero MEP, Espariz M et al. GolS controls the response to gold by the hierarchical induction of Salmonella-specific genes that include a CBA efflux-coding operon. Mol Microbiol. 2007; 66(3):814-25.
27. Bogomolnaya LM, Andrews KD, Talamantes M et al. The ABC-type efflux pump protects Salmonella enterica serovar typhimurium from oxidative stress. MBio. 2013; 4(6):e00630-13
28. Bogomolnaya LM, Tilvawala R, Elfenbein JR et al. Linearized Siderophore Products Secreted via MacAB Efflux Pump Protect Salmonella enterica Serovar Typhimurium from Oxidative Stress. MBio. 2020; 11(3):e00528-20
29. Ricci V, Attah V, Overton T et al. CsrA maximizes expression of the AcrAB multidrug resistance transporter. (Piddock LJV1. Nucleic Acids Res. 2017; 45(22):12798-12807.
30. Fàbrega A, Merle L, Bouguénec CL et al. Repression of invasion genes and decreased invasion in a high-level fluoroquinolone-resistant Salmonella typhimurium mutant. PLoS One. 2009; 4(11):e8029.
31. Barchiesi J, Castelli ME, Soncini F et al. mgtA Expression is induced by rob overexpression and mediates a Salmonella enterica resistance phenotype. J Bacteriol. 2008; 190(14):4951-8.
32. Yamasaki S, Nagasawa S, Fukushima A et al. Cooperation of the multidrug efflux pump and lipopolysaccharides in the intrinsic antibiotic resistance of Salmonella enterica serovar Typhimurium. J Antimicrob Chemother. 2013; 68(5):1066-70.
33. Yamasaki S, Fujioka T, Hayashi K et al. Phenotype microarray analysis of the drug efflux systems in Salmonella enterica serovar Typhimurium. J Infect Chemother. 2016; 22(11):780-4.
34. Lawler AJ, Ricci V, Busby SJW et al. Genetic inactivation of acrAB or inhibition of efflux induces expression of ramA. J Antimicrob Chemother. 2013; 68(7):1551-7.
35. Li L, Yang Y, Lioa X et al. Development of ceftriaxone resistance affects the virulence properties of Salmonella enterica serotype Typhimurium strains. Foodborne Pathog Dis. 2013; 10(1):28-34.
36. Rensch U, Nishino K, Klein G et al. Salmonella enterica serovar Typhimurium multidrug efflux pumps EmrAB and AcrEF support the major efflux system AcrAB in decreased susceptibility to triclosan. Int J Antimicrob Agents. 2014; 44(2):179-80.
37. Cerminati S, Giri GF, Mendoza J et al. The CpxR/CpxA system contributes to Salmonella gold-resistance by controlling the GolS-dependent gesABC transcription. Environ Microbiol. 2017; 19(10):4035-44.
38. Hayashi-Nishino M, Fukushima A, Nishino K. Impact of hfq on the intrinsic drug resistance of salmonella enterica serovar typhimurium. Front Microbiol. 2012; 3:205.
39. Ruiz C and Levy SB. Regulation of acrAB expression by cellular metabolites in Escherichia coli. J Antimicrob Chemother. 2014; 69(2):390-9. doi: 10.
40. Yang S, Lopez CR, Zechiedrich EL. Quorum sensing and multidrug transporters in Escherichia coli. Proc Natl Acad Sci U S A. 2006; 103(7):2386-91.
41. Maira-Litrán T, Allison DG, Gilbert P. Expression of the multiple antibiotic resistance operon (mar) during growth of Escherichia coli as a biofilm. J Appl Microbiol. 2000; 88(2):243-7.
42. Yamasaki S, Wang L, Hirata T et al. Multidrug efflux pumps contribute to Escherichia coli biofilm maintenance. Int J Antimicrob Agents. 2015; 45(4):439-41.
43. Ruhe ZC, Wallace AB, Low DA et al. Receptor polymorphism restricts contact-dependent growth inhibition to members of the same species. MBio. 2013; 4(4). pii: e00480-13.
44. Meouche IE and Dunlop MJ. Heterogeneity in efflux pump expression predisposes antibiotic-resistant cells to mutation. Science. 2018; 362(6415):686-90.
45. Elkins CA and Mullis LB. Mammalian steroid hormones are substrates for the major RND- and MFS-type tripartite multidrug efflux pumps of Escherichia coli. J Bacteriol. 2006; 188(3):1191-5.
46. Matsumura K, Furukawa S, Ogihara H et al. Roles of multidrug efflux pumps on the biofilm formation of Escherichia coli K-12. Biocontrol Sci. 2011; 16(2):69-72.
47. Hirakawa H, Inazumi Y, Masaki T et al. Indole induces the expression of multidrug exporter genes in Escherichia coli. Mol Microbiol. 2005; 55(4):1113-26.
48. Nishino K, Yamasaki S, Hayashi-Nishino M et al. Effect of NlpE overproduction on multidrug resistance in Escherichia coli. Antimicrob Agents Chemother. 2010; 54(5):2239-43.
49. Lau SY and Zgurskaya HI. Cell division defects in Escherichia coli deficient in the multidrug efflux transporter AcrEF-TolC. J Bacteriol. 2005; 187(22):7815-25.
50. Wei Y, Lee JM, Smulski DR et al. Global impact of sdiA amplification revealed by comprehensive gene expression profiling of Escherichia coli. J Bacteriol. 2001; 183(7):2265-72.
51. Zhang Y, Xiao M, Horiyama T et al. The multidrug efflux pump MdtEF protects against nitrosative damage during the anaerobic respiration in Escherichia coli. J Biol Chem. 2011; 286(30):26576-84.
52. Hirakawa H, Nishino K, Yamada J et al. Beta-lactam resistance modulated by the overexpression of response regulators of two-component signal transduction systems in Escherichia coli. J Antimicrob Chemother. 2003; 52(4):576-82.
53. Masuda N and Church GM. Escherichia coli gene expression responsive to levels of the response regulator EvgA. J Bacteriol. 2002; 184(22):6225-34.
54. Hirakawa H, Inazumi Y, Senda Y et al. N-acetyl-d-glucosamine induces the expression of multidrug exporter genes, mdtEF, via catabolite activation in Escherichia coli. J Bacteriol. 2006; 188(16):5851-8.
55. Yamanaka H, Kobayashi H, Takahashi E et al. MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II. J Bacteriol. 2008; 190(23):7693-8.
56. Turlin E, Heuck G, Brandão MIS et al. Protoporphyrin (HPPIX) efflux by the MacAB-TolC pump in Escherichia coli. Microbiologyopen. 2014; 3(6):849-59.
57. Lu S and Zgurskaya HI. MacA, a periplasmic membrane fusion protein of the macrolide transporter MacAB-TolC, binds lipopolysaccharide core specifically and with high affinity. J Bacteriol. 2013; 195(21):4865-72.
58. Lewinson O, Padan E, Bibi E. Alkalitolerance: a biological function for a multidrug transporter in pH homeostasis. Proc Natl Acad Sci U S A. 2004; 101(39):14073-8.
59. Sikdar R, Simmons AR, Doerrler WT. Multiple envelope stress response pathways are activated in an Escherichia coli strain with mutations in two members of the DedA membrane protein family. J Bacteriol. 2013; 195(1):12-24.
60. Deininger KNW, Horikawa A, Kitko RD et al. A requirement of TolC and MDR efflux pumps for acid adaptation and GadAB induction in Escherichia coli. PLoS One. 2011; 6(4):e18960.
61. Sakamoto A, Terui Y, Yoshida T et al. Three members of polyamine modulon under oxidative stress conditions: two transcription factors (SoxR and EmrR) and a glutathione synthetic enzyme (GshA). PLoS One. 2015; 10(4):e0124883.
62. Aoki SK, Malinverni JC, Jacoby K et al. Contact-dependent growth inhibition requires the essential outer membrane protein BamA (YaeT) as the receptor and the inner membrane transport protein AcrB. Mol Microbiol. 2008; 70(2):323-40.
63. Rahmati S, Yang S, Davidson AL et al. Control of the AcrAB multidrug efflux pump by quorum-sensing regulator SdiA. Mol Microbiol. 2002; 43(3):677-85.
64. Rosenberg EY, Bertenthal D, Nilles ML et al. Bile salts and fatty acids induce the expression of Escherichia coli AcrAB multidrug efflux pump through their interaction with Rob regulatory protein. Mol Microbiol. 2003; 48(6):1609-19.
65. Su C, Nikaido H, Yu EW. Ligand-transporter interaction in the AcrB multidrug efflux pump determined by fluorescence polarization assay. FEBS Lett. 2007; 581(25):4972-6.
66. Kobayashi A, Hirakawa H, Hirata T et al. Growth phase-dependent expression of drug exporters in Escherichia coli and its contribution to drug tolerance. J Bacteriol. 2006; 188(16):5693-703.
67. Nishino K, Yamasaki S, Hayashi-Nishino M et al. Effect of overexpression of small non-coding DsrA RNA on multidrug efflux in Escherichia coli. J Antimicrob Chemother. 2011; 66(2):291-6.
68. Bay DC and Turner RJ. Small multidrug resistance protein EmrE reduces host pH and osmotic tolerance to metabolic quaternary cation osmoprotectants. J Bacteriol. 2012; 194(21):5941-8.
69. Wang Da and Fierke CA. The BaeSR regulon is involved in defense against zinc toxicity in E. coli. Metallomics. 2013; 5(4):372-83.
70. Leblanc SKD, Oates CW, Raivio TL. Characterization of the induction and cellular role of the BaeSR two-component envelope stress response of Escherichia coli. J Bacteriol. 2011; 193(13):3367-75.
71. Kim E, Nies DH, McEvoy MM et al. Switch or funnel: how RND-type transport systems control periplasmic metal homeostasis. J Bacteriol. 2011; 193(10):2381-7.
72. Long F, Su C, Zimmermann MT et al. Crystal structures of the CusA efflux pump suggest methionine-mediated metal transport. Nature. 2010; 467(7314):484-8.
73. Evans K, Passador L, Srikumar R et al. Influence of the MexAB-OprM multidrug efflux system on quorum sensing in Pseudomonas aeruginosa. J Bacteriol. 1998; 180(20):5443-7.
74. Sánchez P, Linares JF, Ruiz-Díez B et al. Fitness of in vitro selected Pseudomonas aeruginosa nalB and nfxB multidrug resistant mutants. J Antimicrob Chemother. 2002; 50(5):657-64.
75. Hirakata Y, Srikumar R, Poole K et al. Multidrug efflux systems play an important role in the invasiveness of Pseudomonas aeruginosa. J Exp Med. 2002; 196(1):109-18.
76. Hirakata Y, Kondo A, Hoshino K et al. Efflux pump inhibitors reduce the invasiveness of Pseudomonas aeruginosa. Int J Antimicrob Agents. 2009; 34(4):343-6.
77. Kievit TRD, Parkins MD, Gillis RJ et al. Multidrug efflux pumps: expression patterns and contribution to antibiotic resistance in Pseudomonas aeruginosa biofilms. Antimicrob Agents Chemother. 2001; 45(6):1761-70.
78. Liao J, Schurr MJ, Sauer K. The MerR-like regulator BrlR confers biofilm tolerance by activating multidrug efflux pumps in Pseudomonas aeruginosa biofilms. J Bacteriol. 2013; 195(15):3352-63.
79. Linares JF, López JA, Camafeita E et al. Overexpression of the multidrug efflux pumps MexCD-OprJ and MexEF-OprN is associated with a reduction of type III secretion in Pseudomonas aeruginosa. J Bacteriol. 2005; 187(4):1384-91.
80. Stickland HG, Davenport PW, Lilley KS et al. Mutation of nfxB causes global changes in the physiology and metabolism of Pseudomonas aeruginosa. J Proteome Res. 2010; 9(6):2957-67.
81. Martínez-Ramos I, Mulet X, Moyá B et al. Overexpression of MexCD-OprJ reduces Pseudomonas aeruginosa virulence by increasing its susceptibility to complement-mediated killing. Antimicrob Agents Chemother. 2014; 58(4):2426-9.
82. Strempel N, Neidig A, Nusser M et al. Human host defense peptide LL-37 stimulates virulence factor production and adaptive resistance in Pseudomonas aeruginosa. PLoS One. 2013; 8(12):e82240.
83. Gillis R, White KG, Choi K et al. Molecular basis of azithromycin-resistant Pseudomonas aeruginosa biofilms. Antimicrob Agents Chemother. 2005; 49(9):3858-67.
84. T Köhler, Delden C, Curty LK et al. Overexpression of the MexEF-OprN multidrug efflux system affects cell-to-cell signaling in Pseudomonas aeruginosa. J Bacteriol. 2001; 183(18):5213-22.
85. Olivares J, Alvarez-Ortega C, Linares JF et al. Overproduction of the multidrug efflux pump MexEF-OprN does not impair Pseudomonas aeruginosa fitness in competition tests, but produces specific changes in bacterial regulatory networks. Environ Microbiol. 2012; 14(8):1968-81.
86. Lamarche MG and Déziel E. MexEF-OprN efflux pump exports the Pseudomonas quinolone signal (PQS) precursor HHQ (4-hydroxy-2-heptylquinoline). PLoS One. 2011; 6(9):e24310.
87. Tian Z, Aogáin MM, O'Connor HF et al. MexT modulates virulence determinants in Pseudomonas aeruginosa independent of the MexEF-OprN efflux pump. Microb Pathog. 2009; 47(4):237-41.
88. Wang D, Seeve C, Pierson LS et al. Transcriptome profiling reveals links between ParS/ParR, MexEF-OprN, and quorum sensing in the regulation of adaptation and virulence in Pseudomonas aeruginosa. BMC Genomics. 2013; 14:618.
89. Schaible B, Taylor CT, Schaffer K. Hypoxia increases antibiotic resistance in Pseudomonas aeruginosa through altering the composition of multidrug efflux pumps. Antimicrob Agents Chemother. 2012; 56(4):2114-8.
90. Jeannot K, Sobel ML, Garch FE et al. Induction of the MexXY efflux pump in Pseudomonas aeruginosa is dependent on drug-ribosome interaction. J Bacteriol. 2005; 187(15):5341-6.
91. Caughlan RE, Sriram S, Daigle DM et al. Fmt bypass in Pseudomonas aeruginosa causes induction of MexXY efflux pump expression. Antimicrob Agents Chemother. 2009; 53(12):5015-21.
92. Fraud S and Poole K. Oxidative stress induction of the MexXY multidrug efflux genes and promotion of aminoglycoside resistance development in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2011; 55(3):1068-74.
93. Aendekerk S, Diggle SP, Song Z et al. The MexGHI-OpmD multidrug efflux pump controls growth, antibiotic susceptibility and virulence in Pseudomonas aeruginosa via 4-quinolone-dependent cell-to-cell communication. Microbiology. 2005; 151(Pt 4):1113-25.
94. Aendekerk S, Ghysels B, Cornelis P et al. Characterization of a new efflux pump, MexGHI-OpmD, from Pseudomonas aeruginosa that confers resistance to vanadium. Microbiology. 2002; 148(Pt 8):2371-81.
95. Moore JD, Gerdt JP, Eibergen NR et al. Active efflux influences the potency of quorum sensing inhibitors in Pseudomonas aeruginosa. Chembiochem. 2014; 15(3):435-42.
96. Minagawa S, Inami H, Kato T et al. RND type efflux pump system MexAB-OprM of Pseudomonas aeruginosa selects bacterial languages, 3-oxo-acyl-homoserine lactones, for cell-to-cell communication. BMC Microbiol. 2012; 12:70.
97. Pacheco JO, Alvarez-Ortega C, Rico MA et al. Metabolic Compensation of Fitness Costs Is a General Outcome for Antibiotic-Resistant Pseudomonas aeruginosa Mutants Overexpressing Efflux Pumps. MBio. 2017; 8(4). pii: e00500-17.
98. Zaborskyte G, Andersen JB, Kragh KN et al. Real-Time Monitoring of nfxB Mutant Occurrence and Dynamics in Pseudomonas aeruginosa Biofilm Exposed to Subinhibitory Concentrations of Ciprofloxacin. Antimicrob Agents Chemother. 2017; 61(3). pii: e02292-16.
99. Jeannot K, Elsen S, Köhler T et al. Resistance and virulence of Pseudomonas aeruginosa clinical strains overproducing the MexCD-OprJ efflux pump. Antimicrob Agents Chemother. 2008; 52(7):2455-62.
100. Mandsberg LF, Maciá MD, Bergmann KR et al. Development of antibiotic resistance and up-regulation of the antimutator gene pfpI in mutator Pseudomonas aeruginosa due to inactivation of two DNA oxidative repair genes (mutY, mutM). FEMS Microbiol Lett. 2011; 324(1):28-37.
101. Mandsberg LF, Ciofu O, Kirkby N et al. Antibiotic resistance in Pseudomonas aeruginosa strains with increased mutation frequency due to inactivation of the DNA oxidative repair system. Antimicrob Agents Chemother. 2009; 53(6):2483-91.
102. Lamarche MG and Déziel E. MexEF-OprN efflux pump exports the Pseudomonas quinolone signal (PQS) precursor HHQ (4-hydroxy-2-heptylquinoline). PLoS One. 2011; 6(9):e24310.
103. Olivares J, Alvares-Ortega C, Linares JF et al. Overproduction of the multidrug efflux pump MexEF-OprN does not impair Pseudomonas aeruginosa fitness in competition tests, but produces specific changes in bacterial regulatory networks. Environ Microbiol. 2012; 14(8):1968-81.
104. Oshri RD, Zrihen KS, Shner I et al. Selection for increased quorum-sensing cooperation in Pseudomonas aeruginosa through the shut-down of a drug resistance pump. ISME J. 2018; 12:2458-2469.
105. Fetar H, Gilmour C, Klinoski R et al. mexEF-oprN multidrug efflux operon of Pseudomonas aeruginosa: regulation by the MexT activator in response to nitrosative stress and chloramphenicol. Antimicrob Agents Chemother. 2011; 55(2):508-14.
106. Fargier E, Aogáin MM, Mooij MJ et al. MexT functions as a redox-responsive regulator modulating disulfide stress resistance in Pseudomonas aeruginosa. J Bacteriol. 2012; 194(13):3502-11.
107. Sporer AJ, Beierschmitt C, Bendebury A et al. Pseudomonas aeruginosa PumA acts on an endogenous phenazine to promote self-resistance. Microbiology. 2018; 164(5):790-800.
108. Sakhtah H, Koyama L, Zhang Y et al. The Pseudomonas aeruginosa efflux pump MexGHI-OpmD transports a natural phenazine that controls gene expression and biofilm development. Proc Natl Acad Sci U S A. 2016; 113(25):E3538-47.
109. Caille O, Rossier C, Perron K. A copper-activated two-component system interacts with zinc and imipenem resistance in Pseudomonas aeruginosa. J Bacteriol. 2007; 189(13):4561-8.
110. Perron K, Caille O, Rossier C et al. CzcR-CzcS, a two-component system involved in heavy metal and carbapenem resistance in Pseudomonas aeruginosa. J Biol Chem. 2004; 279(10):8761-8.
111. Masuda N, Sakagawa E, Ohya S et al. Substrate specificities of MexAB-OprM, MexCD-OprJ, and MexXY-oprM efflux pumps in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2000; 44(12):3322-7.
112. Fraud S, Campigotto AJ, Chen Z et al. MexCD-OprJ multidrug efflux system of Pseudomonas aeruginosa: involvement in chlorhexidine resistance and induction by membrane-damaging agents dependent upon the AlgU stress response sigma factor. Antimicrob Agents Chemother. 2008; 52(12):4478-82.
113. Wolloscheck D, Krishnamoorthy, Nguyen J et al. Kinetic Control of Quorum Sensing in Pseudomonas aeruginosa by Multidrug Efflux Pumps. ACS Infect Dis. 2018; 4(2):185-95.
114. Sekiya H, Mima T, Morita Y et al. Functional cloning cmp, mexHI-opmD, from a Pseudomonas aeruginosa mutant. Antimicrob Agents Chemother. 2003; 47(9):2990-2.
115. Li Y, Mima T, Komori Y et al. A new member of the tripartite multidrug efflux pumps, MexVW-OprM, in Pseudomonas aeruginosa. J Antimicrob Chemother. 2003; 52(4):572-5.
116. Chuanchuen R, Murata T, Gotoh N et al. Substrate-dependent utilization of OprM or OpmH by the Pseudomonas aeruginosa MexJK efflux pump. Antimicrob Agents Chemother. 2005; 49(5):2133-6.
117. Mima T, Sekiya H, Mizushima T et al. Gene cloning and properties of the RND-type multidrug efflux pumps MexPQ-OpmE and MexMN-OprM from Pseudomonas aeruginosa. Microbiol Immunol. 2005; 49(11):999-1002
118. Nishino K, Yamada J, Hirakawa H et al. Roles of TolC-dependent multidrug transporters of Escherichia coli in resistance to -lactams. Antimicrob. Agents Chemother. 2003; 47:3030-33.
119. Sulavik MC, Houseweart C, Cramer C et al. Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes. Antimicrob. Agents Chemother. 2001; 45:1126-36.
120. Jensen KF. The Escherichia coli K-12 “wild types” W3110 and MG1655 have an rph frameshift mutation that leads to pyrimidine starvation due to low pyrE expression levels. J. Bacteriol. 1993; 175:3401-7.
121. Veen HW, Venema K, Bolhuis H et al. Multidrug resistance mediated by a bacterial homolog of the human multidrug transporter MDR1. Proc. Natl. Acad. Sci. U. S. A. 1996; 93:10668-72.
122. Saier MH, Chauvaux S, Deutscher J et al. Protein phosphorylation and regulation of carbon metabolism in gram-negative versus gram-positive bacteria. Trends Biochem. Sci. 1995; 20(7):267-71.
123. Kotra P, Inui M, Yukawa H. Bacterial phosphotransferase system (PTS) in carbohydrate uptake and control of carbon metabolism. J. Biosci. Bioeng. 2001; 92(6):502-17.
124. Sado-Kamdem SL, Vannini L, Guerzoni ME. Effect of -linolenic, capric and lauric acid on the fatty acid biosynthesis in Staphylococcus aureus. Int. J. Food Microbio 2009; 129, 288–294.
125. Yoon BK, Jackman JA. Valle-González et al. Antibacterial Free Fatty Acids and Monoglycerides: Biological Activities, Experimental Testing, and Therapeutic Applications. Int J Mol Sci 2018; 19: 1114.
126. Shapiro S. The inhibitory action of fatty acids on oral bacteria. Oral Microbial Immunol 1996; 5: 350-5.
127. Villagra NA, Hidalgo AA, Santiviago CA et al. Inhibitory action of fatty acids on the growth of Neisseria gonorrhoeae. J Antimicrob Chemother 1997; 17: 303-12.
128. Chamberlain NR, Mehrtens BG, Xiong Z et al. Correlation of carotenoid production, decreased membrane fluidity, and resistance to oleic acid killing in Staphylococcus aureus 18Z. Infect Immun 1991; 59: 4332-37.
129. Desbois AP and Smith V. Antibacterial free fatty acids: activities, mechanisms of action and biotechnological potential. Appl Microbiol Biotechnol 2010; 85: 1629-42.
130. Gunn JS. Mechanisms of bacterial resistance and response to bile. Microbes Infect 2000; 2: 907-13.
131. Prouty AM, Brodsky IE, Falkow S. Bile-salt-mediated induction of antimicrobial and bile resistance in Salmonella typhimurium.. Microbiology 2004; 150: 775-83.
132. Ma D, Cook DN, Alberti M, Pon NG, Nikaido H, Hearst JE. Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli. Mol Microbiol. 1995; 16: 45-55.
133. Wotzka SY, Kreuzer M, Maier L, Arnoldini M, Nguyen BD, Brachmann AO, et al. Escherichia coli limits Salmonella Typhimurium infections after diet shifts and fat-mediated microbiota perturbation in mice. Nat Microbiol. 2019; 4: 2164-74.
134. Henderson PJ, Maher C, Elbourne LDH, Eijkelkamp BA, Paulsen IT, Hassan KA. Physiological Functions of Bacterial “Multidrug” Efflux Pumps. Chem Rev. 2021; 121: 5417-78.
135. Fields PI, Swanson RV, Haidaris CG et al. Mutants of Salmonella typhimurium that cannot survive within the macrophage are avirulent. Proc Natl Acad Sci USA. 1986; 83: 5189-93.
136. Blattner FR, Plunkett G, Bloch CA et al. The complete genome sequence of Escherichia coli K-12. Science. 1997; 277: 1453-62.
137. Stover CK, Pham XQ, Erwin AL et al. Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000; 406: 959-64.
138. Datsenko KA and Wanner BL. One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc Natl Acad Sci USA. 2000; 97: 6640-5.
139. Horiyama T, Nikaido E, Yamaguchi A et al. Roles of Salmonella multidrug efflux pumps in tigecycline resistance. J Antimicrob Chemother. 2011; 66: 105-10.
140. Sekiya H, Mima T, Morita Y at al. Functional cloning and characterization of a multidrug efflux pump, mexHI-opmD, from a Pseudomonas aeruginosa mutant. Antimicrob Agents Chemother. 2003; 47: 2990-2.
141. Nishino K, Yamaguchi A. Role of histone-like protein H-NS in multidrug resistance of Escherichia coli. J Bacteriol 2004; 186: 1423-9.
142. Miller JH. Experiments in Molecular Genetics. Cold Spring Harbor Laboratory Press Cold Spring Harbor, NY. 1972; 352–5.
143. Lomovskaya O, Lewis K. Matin A. EmrR is a negative regulator of the Escherichia coli multidrug resistance pump EmrAB. J Bacteriol 1995;177: 2328-34.
144. Eswaran J, Hughes C, Koronakis V. Locking TolC entrance helices to prevent protein translocation by the bacterial type I export apparatus. J Mol Biol 2003; 327: 309-15.
145. Baucheron S, Chaslus-Dancla E, Cloeckaert A. Role of TolC and parC mutation in high-level fluoroquinolone resistance in Salmonella enterica serotype Typhimurium DT204. J Antimicrob Chemother 2004; 53: 657-9.
146. Yousefian N, Ornik-Cha A, Poussard S et al. Structural characterization of the EmrAB-TolC efflux complex from E. coli. Biochim Biophys Acta Biomembr 2021; 1863: 183488.
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