1. Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020:
GLOBOCAN estimates of incidence and mortality worldwide
for 36 cancers in 185 countries. CA Cancer J Clin.
2021;71:209–49.
2. Arain MA, Sawhney M, Sheikh S, et al. CIMP status of interval
colon cancers: another piece to the puzzle. Am J Gastroenterol.
2010;105:1189–95.
3. Cooper GS, Xu F, Barnholtz Sloan JS, et al. Prevalence and
predictors of interval colorectal cancers in medicare beneficiaries. Cancer. 2012;118:3044–52.
4. Gorski TF, Rosen L, Riether R, et al. Colorectal cancer after
surveillance colonoscopy: false-negative examination or fast
growth? Dis Colon Rectum. 1999;42:877–80.
5. Lee YM, Huh KC. Clinical and biological features of interval
colorectal cancer. Clin Endosc. 2017;50:254–60.
6. Singh H, Nugent Z, Demers AA, et al. Rate and predictors of
early/missed colorectal cancers after colonoscopy in Manitoba:
population-based
study.
Am
Gastroenterol.
2010;105:2588–96.
7. Longacre TA, Fenoglio-Preiser CM. Mixed hyperplastic adenomatous polyps/serrated adenomas. A distinct form of colorectal neoplasia. Am J Surg Pathol. 1990;14:524–37.
8. Goldman H, Ming S, Hickock DF. Nature and significance of
hyperplastic polyps of the human colon. Arch Pathol.
1970;89:349–4.
9. Ij JE, Vermeulen L, Meijer GA, et al. Serrated neoplasia-role in
colorectal carcinogenesis and clinical implications. Nat Rev
Gastroenterol Hepatol. 2015;12:401–9.
10. Leggett B, Whitehall V. Role of the serrated pathway in colorectal
cancer
pathogenesis.
Gastroenterology.
2010;138:2088–100.
11. Bettington M, Walker N, Clouston A, et al. The serrated pathway to colorectal carcinoma: current concepts and challenges.
Histopathology. 2013;62:367–86.
12. O’Brien MJ, Zhao Q, Yang S. Colorectal serrated pathway
cancers and precursors. Histopathology. 2015;66:49–65.
13. Rosty C, Hewett DG, Brown IS, et al. Serrated polyps of the
large intestine: current understanding of diagnosis, pathogenesis,
and clinical management. J Gastroenterol. 2013;48:287–302.
14. Lash RH, Genta RM, Schuler CM. Sessile serrated adenomas:
prevalence of dysplasia and carcinoma in 2139 patients. J Clin
Pathol. 2010;63:681–6.
15. Bettington M, Walker N, Rosty C, et al. Clinicopathological and
molecular features of sessile serrated adenomas with dysplasia
or carcinoma. Gut. 2017;66:97–106.
16. Murakami T, Kurosawa T, Fukushima H, et al. Sessile serrated
lesions: clinicopathological characteristics, endoscopic diagnosis, and management. Dig Endosc. 2022;34:1096–109.
J Gastroenterol (2023) 58:705–717
17. Burgess NG, Tutticci NJ, Pellise M, et al. Sessile serrated adenomas/polyps with cytologic dysplasia: a triple threat for
interval cancer. Gastrointest Endosc. 2014;80:307–10.
18. Nanda KS, Tutticci N, Burgess N, et al. Caught in the act:
endoscopic characterization of sessile serrated adenomas with
dysplasia. Gastrointest Endosc. 2014;79:864–70.
19. Pohl H, Srivastava A, Bensen SP, et al. Incomplete polyp
resection during colonoscopy-results of the complete adenoma
resection (CARE) study. Gastroenterology. 2013;144:74-80.e1.
20. Kamba S, Tamai N, Saitoh I, et al. Reducing adenoma miss rate
of colonoscopy assisted by artificial intelligence: a multicenter
randomized controlled trial. J Gastroenterol. 2021;56:746–57.
21. Pei L, Liu Y, Liu L, et al. Roles of cancer-associated fibroblasts
(CAFs) in anti- PD-1/PD-L1 immunotherapy for solid cancers.
Mol Cancer. 2023;22:29.
22. Jin Z, Sinicrope FA. Mismatch repair-deficient colorectal cancer: building on checkpoint blockade. J Clin Oncol.
2022;40:2735–50.
23. Anderson NM, Simon MC. The tumor microenvironment. Curr
Biol. 2020;30:R921-5.
24. WHO Classification of Tumours Editorial Board. WHO Classification of Tumors: Digestive System Tumours. 5th ed. Lyon:
International Agency for Reasearch on Cancer; 2019.
25. Crockett SD, Nagtegaal ID. Terminology, molecular features,
epidemiology, and management of serrated colorectal neoplasia.
Gastroenterology. 2019;157:949-66.e4.
26. Mezzapesa M, Losurdo G, Celiberto F, et al. Serrated colorectal
lesions: an up-to-date review from histological pattern to
molecular pathogenesis. Int J Mol Sci. 2022;23:4461.
27. Bettington M, Walker N, Rosty C, et al. Critical appraisal of the
diagnosis of the sessile serrated adenoma. Am J Surg Pathol.
2014;38:158–66.
28. Torlakovic E, Skovlund E, Snover DC, et al. Morphologic
reappraisal of serrated colorectal polyps. Am J Surg Pathol.
2003;27:65–81.
29. Kambara T, Simms LA, Whitehall VL, et al. BRAF mutation is
associated with DNA methylation in serrated polyps and cancers
of the colorectum. Gut. 2004;53:1137–44.
30. Jass JR. Classification of colorectal cancer based on correlation
of clinical, morphological and molecular features. Histopathology. 2007;50:113–30.
31. Sheridan TB, Fenton H, Lewin MR, et al. Sessile serrated adenomas with low- and high-grade dysplasia and early carcinomas:
an immunohistochemical study of serrated lesions ‘‘caught in
the act.’’ Am J Clin Pathol. 2006;126:564–71.
32. Goldstein NS, Bhanot P, Odish E, et al. Hyperplastic-like colon
polyps that preceded microsatellite-unstable adenocarcinomas.
Am J Clin Pathol. 2003;119:778–96.
33. Phipps AI, Limburg PJ, Baron JA, et al. Association between
molecular subtypes of colorectal cancer and patient survival.
Gastroenterology. 2015;148:77-87.e2.
34. Hazewinkel Y, de Wijkerslooth TR, Stoop EM, et al. Prevalence
of serrated polyps and association with synchronous advanced
neoplasia
in
screening
colonoscopy.
Endoscopy.
2014;46:219–24.
35. Carr NJ, Mahajan H, Tan KL, et al. Serrated and non-serrated
polyps of the colorectum: their prevalence in an unselected case
series and correlation of BRAF mutation analysis with the
diagnosis of sessile serrated adenoma. J Clin Pathol.
2009;62:516–8.
36. Torlakovic EE, Gomez JD, Driman DK, et al. Sessile serrated
adenoma (SSA) vs. traditional serrated adenoma (TSA). Am J
Surg Pathol. 2008;32:21–9.
37. Sano W, Hirata D, Teramoto A, et al. Serrated polyps of the
colon and rectum: remove or not? World J Gastroenterol.
2020;26:2276–85.
715
38. McCarthy AJ, Serra S, Chetty R. Traditional serrated adenoma:
an overview of pathology and emphasis on molecular pathogenesis. BMJ Open Gastroenterol. 2019;6: e000317.
39. Bettington ML, Walker NI, Rosty C, et al. A clinicopathological
and molecular analysis of 200 traditional serrated adenomas.
Mod Pathol. 2015;28:414–27.
40. Tsai JH, Liau JY, Lin YL, et al. Traditional serrated adenoma
has two pathways of neoplastic progression that are distinct from
the sessile serrated pathway of colorectal carcinogenesis. Mod
Pathol. 2014;27:1375–85.
41. Hashimoto T, Tanaka Y, Ogawa R, et al. Superficially serrated
adenoma: a proposal for a novel subtype of colorectal serrated
lesion. Mod Pathol. 2018;31:1588–98.
42. Mizuguchi Y, Tanaka Y, Cho H, et al. Endoscopic features of
isolated and traditional serrated adenoma-associated superficially serrated adenomas of the colorectum. Dig Endosc.
2022;34:153–62.
43. Togashi K. Superficially serrated adenoma: Novel precursor in
the serrated pathway. Dig Endosc. 2022;34:77–8.
44. Abdeljawad K, Vemulapalli KC, Kahi CJ, et al. Sessile serrated
polyp prevalence determined by a colonoscopist with a high
lesion detection rate and an experienced pathologist. Gastrointest Endosc. 2015;81:517–24.
45. Ij JE, de Wit K, van der Vlugt M, et al. Prevalence, distribution
and risk of sessile serrated adenomas/polyps at a center with a
high adenoma detection rate and experienced pathologists.
Endoscopy. 2016;48:740–6.
46. Kumbhari V, Behary J, Hui JM. Prevalence of adenomas and
sessile serrated adenomas in Chinese compared with Caucasians. J Gastroenterol Hepatol. 2013;28:608–12.
47. Snover DC. Sessile serrated adenoma/polyp of the large intestine: a potentially aggressive lesion in need of a new screening
strategy. Dis Colon Rectum. 2011;54:1205–6.
48. Yang JF, Tang SJ, Lash RH, et al. Anatomic distribution of
sessile serrated adenoma/polyp with and without cytologic
dysplasia. Arch Pathol Lab Med. 2015;139:388–93.
49. Amemori S, Yamano HO, Tanaka Y, et al. Sessile serrated
adenoma/polyp showed rapid malignant transformation in the
final 13 months. Dig Endosc. 2020;32:979–83.
50. Oono Y, Fu K, Nakamura H, et al. Progression of a sessile
serrated adenoma to an early invasive cancer within 8 months.
Dig Dis Sci. 2009;54:906–9.
51. Kinoshita S, Nishizawa T, Uraoka T. Progression to invasive
cancer from sessile serrated adenoma/polyp. Dig Endosc.
2018;30:266.
52. Murakami T, Sakamoto N, Ritsuno H, et al. Distinct endoscopic
characteristics of sessile serrated adenoma/polyp with and
without
dysplasia/carcinoma.
Gastrointest
Endosc.
2017;85:590–600.
53. Liu C, Walker NI, Leggett BA, et al. Sessile serrated adenomas
with dysplasia: morphological patterns and correlations with
MLH1 immunohistochemistry. Mod Pathol. 2017;30:1728–38.
54. World Health Organization, International Agency for Reasearch
on Cancer. World Health Organization classification of tumours
of the digestive system. 4th ed. Lyon: International Agency for
Reasearch on Cancer; 2010.
55. Bettington M, Liu C, Gill A, et al. BRAF V600E immunohistochemistry demonstrates that some sessile serrated lesions with
adenomatous dysplasia may represent collision lesions.
Histopathology. 2019;75:81–7.
56. Sano W, Fujimori T, Ichikawa K, et al. Clinical and endoscopic
evaluations of sessile serrated adenoma/polyps with cytological
dysplasia. J Gastroenterol Hepatol. 2018;33:1454–60.
57. Rau TT, Atreya R, Aust D, et al. Inflammatory response in
serrated precursor lesions of the colon classified according to
123
716
58.
59.
60.
61.
62.
63.
64.
65.
66.
67.
68.
69.
70.
71.
72.
73.
74.
75.
76.
J Gastroenterol (2023) 58:705–717
WHO entities, clinical parameters and phenotype-genotype
correlation. J Pathol Clin Res. 2016;2:113–24.
Acosta-Gonzalez G, Ouseph M, Lombardo K, et al. Immune
environment in serrated lesions of the colon: intraepithelial
lymphocyte density, PD-1, and PD-L1 expression correlate with
serrated neoplasia pathway progression. Hum Pathol.
2019;83:115–23.
Spring KJ, Zhao ZZ, Karamatic R, et al. High prevalence of
sessile serrated adenomas with BRAF mutations: a prospective
study of patients undergoing colonoscopy. Gastroenterology.
2006;131:1400–7.
Wang L, Cunningham JM, Winters JL, et al. BRAF mutations in
colon cancer are not likely attributable to defective DNA mismatch repair. Cancer Res. 2003;63:5209–12.
Koinuma K, Shitoh K, Miyakura Y, et al. Mutations of BRAF
are associated with extensive hMLH1 promoter methylation in
sporadic colorectal carcinomas. Int J Cancer. 2004;108:237–42.
Minoo P, Moyer MP, Jass JR. Role of BRAF-V600E in the
serrated pathway of colorectal tumourigenesis. J Pathol.
2007;212:124–33.
Snover DC. Update on the serrated pathway to colorectal carcinoma. Hum Pathol. 2011;42:1–10.
Toyota M, Ahuja N, Ohe-Toyota M, et al. CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci USA.
1999;96:8681–6.
Park SJ, Rashid A, Lee JH, et al. Frequent CpG island methylation in serrated adenomas of the colorectum. Am J Pathol.
2003;162:815–22.
Hashimoto T, Yamashita S, Yoshida H, et al. WNT pathway
gene mutations are associated with the presence of dysplasia in
colorectal sessile serrated adenoma/polyps. Am J Surg Pathol.
2017;41:1188–97.
Chen B, Scurrah CR, McKinley ET, et al. Differential pre-malignant programs and microenvironment chart distinct paths to
malignancy in human colorectal polyps. Cell. 2021;184:626280.e26.
Zhou YJ, Lu XF, Chen H, et al. Single-cell transcriptomics
reveals early molecular and immune alterations underlying the
serrated neoplasia pathway toward colorectal cancer. Cell Mol
Gastroenterol Hepatol. 2023;15:393–424.
Murakami T, Akazawa Y, Yatagai N, et al. Molecular characterization of sessile serrated adenoma/polyps with dysplasia/carcinoma based on immunohistochemistry, nextgeneration sequencing, and microsatellite instability testing: a
case series study. Diagn Pathol. 2018;13:88.
De Sousa EMF, Wang X, Jansen M, et al. Poor-prognosis colon
cancer is defined by a molecularly distinct subtype and develops
from serrated precursor lesions. Nat Med. 2013;19:614–8.
Nakanishi Y, Diaz-Meco MT, Moscat J. Serrated colorectal
cancer: the road less travelled? Trends Cancer. 2019;5:742–54.
Nakanishi Y, Duran A, L’Hermitte A, et al. Simultaneous loss of
both atypical protein kinase c genes in the intestinal epithelium
drives serrated intestinal cancer by impairing immunosurveillance. Immunity. 2018;49:1132-47.e7.
He Z, Chen L, Chen G, et al. Interleukin 1 beta and matrix
metallopeptidase 3 contribute to development of epidermal
growth factor receptor-dependent serrated polyps in mouse
cecum. Gastroenterology. 2019;157:1572-83.e8.
Fessler E, Drost J, van Hooff SR, et al. TGFb signaling directs
serrated adenomas to the mesenchymal colorectal cancer subtype. EMBO Mol Med. 2016;8:745–60.
Leach JDG, Vlahov N, Tsantoulis P, et al. Oncogenic BRAF,
unrestrained by TGFb-receptor signalling, drives right-sided
colonic tumorigenesis. Nat Commun. 2021;12:3464.
Martinez-Ordon˜ez A, Duran A, Ruiz-Martinez M, et al.
Hyaluronan driven by epithelial aPKC deficiency remodels the
123
77.
78.
79.
80.
81.
82.
83.
84.
85.
86.
87.
88.
89.
90.
91.
92.
93.
94.
95.
microenvironment and creates a vulnerability in mesenchymal
colorectal cancer. Cancer Cell. 2023;41:252-71.e9.
Ouahoud S, Westendorp BF, Voorneveld PW, et al. Loss of
bone morphogenetic protein signaling in fibroblasts results in
CXCL12-driven serrated polyp development. J Gastroenterol.
2023;58:25–43.
Kashida H. Endoscopic diagnosis of sessile serrated polyp: a
systematic review. Dig Endosc. 2019;31:16–23.
Hirata D, Kashida H, Matsumoto T, et al. A multicenter
prospective validation study on selective endoscopic resection of
sessile serrated lesions using magnifying colonoscopy in clinical
practice. Digestion. 2023. https://doi.org/10.1159/000527978.
Hazewinkel Y, Lo´pez-Cero´n M, East JE, et al. Endoscopic
features of sessile serrated adenomas: validation by international
experts using high-resolution white-light endoscopy and narrowband imaging. Gastrointest Endosc. 2013;77:916–24.
Ij JE, Bastiaansen BA, van Leerdam ME, et al. Development
and validation of the WASP classification system for optical
diagnosis of adenomas, hyperplastic polyps and sessile serrated
adenomas/polyps. Gut. 2016;65:963–70.
Nakao Y, Saito S, Ohya T, et al. Endoscopic features of colorectal serrated lesions using image-enhanced endoscopy with
pathological analysis. Eur J Gastroenterol Hepatol.
2013;25:981–8.
Uraoka T, Higashi R, Horii J, et al. Prospective evaluation of
endoscopic criteria characteristic of sessile serrated adenomas/
polyps. J Gastroenterol. 2015;50:555–63.
Yamashina T, Takeuchi Y, Uedo N, et al. Diagnostic features of
sessile serrated adenoma/polyps on magnifying narrow band
imaging: a prospective study of diagnostic accuracy. J Gastroenterol Hepatol. 2015;30:117–23.
Yamada M, Sakamoto T, Otake Y, et al. Investigating endoscopic features of sessile serrated adenomas/polyps by using
narrow-band imaging with optical magnification. Gastrointest
Endosc. 2015;82:108–17.
Ishigooka S, Nomoto M, Obinata N, et al. Evaluation of magnifying colonoscopy in the diagnosis of serrated polyps. World J
Gastroenterol. 2012;18:4308–16.
Kimura T, Yamamoto E, Yamano HO, et al. A novel pit pattern
identifies the precursor of colorectal cancer derived from sessile
serrated adenoma. Am J Gastroenterol. 2012;107:460–9.
Sano Y, Tanaka S, Kudo SE, et al. Narrow-band imaging (NBI)
magnifying endoscopic classification of colorectal tumors proposed by the Japan NBI Expert Team. Dig Endosc.
2016;28:526–33.
Iwatate M, Sano Y, Tanaka S, et al. Validation study for
development of the Japan NBI Expert Team classification of
colorectal lesions. Dig Endosc. 2018;30:642–51.
Kudo S, Hirota S, Nakajima T, et al. Colorectal tumours and pit
pattern. J Clin Pathol. 1994;47:880–5.
Kudo S, Tamura S, Nakajima T, et al. Diagnosis of colorectal
tumorous lesions by magnifying endoscopy. Gastrointest
Endosc. 1996;44:8–14.
Kudo S, Rubio CA, Teixeira CR, et al. Pit pattern in colorectal
neoplasia: endoscopic magnifying view. Endoscopy.
2001;33:367–73.
Murakami T, Sakamoto N, Fukushima H, et al. Usefulness of the
Japan narrow-band imaging expert team classification system
for the diagnosis of sessile serrated lesion with dysplasia/carcinoma. Surg Endosc. 2021;35:4528–38.
Tanaka Y, Yamano HO, Yamamoto E, et al. Endoscopic and
molecular characterization of colorectal sessile serrated adenoma/polyps with cytologic dysplasia. Gastrointest Endosc.
2017;86:1131-8.e4.
Burgess NG, Pellise M, Nanda KS, et al. Clinical and endoscopic predictors of cytological dysplasia or cancer in a
J Gastroenterol (2023) 58:705–717
96.
97.
98.
99.
100.
101.
102.
103.
104.
105.
106.
107.
prospective multicentre study of large sessile serrated adenomas/
polyps. Gut. 2016;65:437–46.
Tate DJ, Jayanna M, Awadie H, et al. A standardized imaging
protocol for the endoscopic prediction of dysplasia within sessile
serrated polyps (with video). Gastrointest Endosc. 2018;87:22231.e2.
Aoki H, Yamamoto E, Yamano HO, et al. Subtypes of the type ii
pit pattern reflect distinct molecular subclasses in the serrated
neoplastic pathway. Dig Dis Sci. 2018;63:1920–8.
Kawamura T, Takeuchi Y, Asai S, et al. A comparison of the
resection rate for cold and hot snare polypectomy for 4–9 mm
colorectal polyps: a multicentre randomised controlled trial
(CRESCENT study). Gut. 2018;67:1950–7.
Uraoka T, Takizawa K, Tanaka S, et al. Guidelines for colorectal cold polypectomy (supplement to ‘‘guidelines for colorectal endoscopic submucosal dissection/endoscopic mucosal
resection’’). Dig Endosc. 2022;34:668–75.
Chang LC, Chang CY, Chen CY, et al. Cold versus hot snare
polypectomy for small colorectal polyps: a pragmatic randomized controlled trial. Ann Intern Med. 2023;176:311–9.
Tanaka S, Saitoh Y, Matsuda T, et al. Evidence-based clinical
practice guidelines for management of colorectal polyps. J Gastroenterol. 2021;56:323–35.
Tate DJ, Awadie H, Bahin FF, et al. Wide-field piecemeal cold
snare polypectomy of large sessile serrated polyps without a
submucosal injection is safe. Endoscopy. 2018;50:248–52.
Rameshshanker R, Tsiamoulos Z, Latchford A, et al. Resection
of large sessile serrated polyps by cold piecemeal endoscopic
mucosal resection: serrated COld Piecemeal Endoscopic
mucosal resection (SCOPE). Endoscopy. 2018;50:E165-7.
Mangira D, Cameron K, Simons K, et al. Cold snare piecemeal
EMR of large sessile colonic polyps C20 mm (with video).
Gastrointest Endosc. 2020;91:1343–52.
Kimoto Y, Sakai E, Inamoto R, et al. Safety and efficacy of cold
snare polypectomy without submucosal injection for large sessile serrated lesions: a prospective study. Clin Gastroenterol
Hepatol. 2022;20:e132-8.
Barros RA, Monteverde MJ, Dumonceau JM, et al. Cold snare
polypectomy without submucosal injection: safety and efficacy
in 615 large serrated lesions. Endosc Int Open. 2021;9:E1421-6.
van Hattem WA, Shahidi N, Vosko S, et al. Piecemeal cold
snare polypectomy versus conventional endoscopic mucosal
resection for large sessile serrated lesions: a retrospective
comparison
across
two
successive
periods.
Gut.
2021;70:1691–7.
717
108. Yoshida N, Inoue K, Tomita Y, et al. Cold snare polypectomy
for large sessile serrated lesions is safe but follow-up is needed:
a single-centre retrospective study. United European Gastroenterol J. 2021;9:370–7.
109. Suzuki S, Gotoda T, Kusano C, et al. Width and depth of
resection for small colorectal polyps: hot versus cold snare
polypectomy. Gastrointest Endosc. 2018;87:1095–103.
110. Ito A, Suga T, Ota H, et al. Resection depth and layer of cold
snare polypectomy versus endoscopic mucosal resection. J Gastroenterol. 2018;53:1171–8.
111. Tutticci N, Burgess NG, Pellise M, et al. Characterization and
significance of protrusions in the mucosal defect after cold snare
polypectomy. Gastrointest Endosc. 2015;82:523–8.
112. Murakami T, Sakamoto N, Nagahara A. Clinicopathological
features, diagnosis, and treatment of sessile serrated adenoma/
polyp with dysplasia/carcinoma. J Gastroenterol Hepatol.
2019;34:1685–95.
113. Seo GJ, Sohn DK, Han KS, et al. Recurrence after endoscopic
piecemeal mucosal resection for large sessile colorectal polyps.
World J Gastroenterol. 2010;16:2806–11.
114. Saito Y, Fukuzawa M, Matsuda T, et al. Clinical outcome of
endoscopic submucosal dissection versus endoscopic mucosal
resection of large colorectal tumors as determined by curative
resection. Surg Endosc. 2010;24:343–52.
115. Hassan C, Quintero E, Dumonceau JM, et al. Post-polypectomy
colonoscopy surveillance: European Society of Gastrointestinal
Endoscopy (ESGE) Guideline. Endoscopy. 2013;45:842–51.
116. Hassan C, Antonelli G, Dumonceau JM, et al. Post-polypectomy
colonoscopy surveillance: European society of gastrointestinal
endoscopy (ESGE) guideline-update 2020. Endoscopy.
2020;52:687–700.
117. Lieberman DA, Rex DK, Winawer SJ, et al. Guidelines for
colonoscopy surveillance after screening and polypectomy: a
consensus update by the US multi-society task force on colorectal cancer. Gastroenterology. 2012;143:844–57.
118. Nakamura F, Sato Y, Okamoto K, et al. Colorectal carcinoma
occurring via the adenoma-carcinoma pathway in patients with
serrated polyposis syndrome. J Gastroenterol. 2022;57:286–99.
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