一般住民における多疾患重積は脆弱性骨折のリスクである

概要

Fragility fracture (FFx), which is a common musculoskeletal injury in older adults,
is associated with an increased frequency of falls. It is generally believed that the cooccurrence of multiple diseases, or multimorbidity, and the use of multiple drugs, or
polypharmacy, will lead to an increased frequency of falls and the risk of fractures. Thus,
we conducted this study to understand the current situation of FFx and multimorbidity in
rural area in Japan and to evaluate the effects of multimorbidity on falls and FFx in the
general elderly population.
The Charlson Comorbidity Index (CCI), which is an effective scale for estimating
the mortality of patients with multiple comorbidities, has been used to analyze
multimorbidity. Both comorbidities and the FFx risk increase with age and, therefore, we
used the age-adjusted Charlson Comorbidity (AAC) index, which has better utility than
CCI.
MATERIALS AND METHODS
This study was undertaken as a part of a cohort study (Shimane CoHRE Study)
conducted by the Center for Community-based Health Research between 2015 and 2016
and written informed consent was obtained from all study participants. (The study
protocol was approved by the Ethics Committee of Shimane University [#2888]). The
data were collected from the health examinations of 1,420 community-dwelling
individuals aged 60 years and older (556 men and 864 women) and the history of clinical
FFx and falls was assessed using a self-reported questionnaire. ...