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miR-215 regulates the homeostasis of small intestine

Sanchenkova, Ksenia 大阪大学 DOI:10.18910/85439

2021.09.24

概要

MicroRNAs are a class of non-coding short-chained RNAs, which control many functions of a cell by down-regulating their target genes. Recent works indicate that miRNAs play a role in the maintenance of a gut homeostasis. miR-215 was found to be highly expressed in the epithelial cells of the small intestine, however the involvement of miR-215 in gut immunity was until now unknown. Here, we show that miR-215 downregulates CXCL12, which leads to elevated recruitment of Th17 cells into small intestine, resulting in a strong inflammation. Mice lacking miR-215 showed increased number of Th17 cells in the lamina propria of the small intestine with the enhanced CXCL12 expression in the epithelial cells. The mutant mice further showed the high susceptibility to an inflammation induced by indomethacin. Our finding opens a promising perspective of targeting miR-215 to treat inflammatory conditions in small intestine.

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