論文の公開元へCompetency of iPSC-derived retinas in MHC-mismatched transplantation in non-human primates
概要
Stem-cell-based therapy is a promising approach for
restoring and reconstructing visual function in patients
with retinal degeneration. The development of innovative
protocols for retinal organoid induction from mouse embryonic stem cells (ESCs) (Eiraku et al., 2011), followed by those
using human ESCs and induced pluripotent stem cells
(iPSCs) (Kuwahara et al., 2015; Meyer et al., 2011; Nakano
et al., 2012; Tu et al., 2019; Zhong et al., 2014), has accelerated research on the clinical application of stem-cell-based
therapies, with further improvement in differentiation protocols (Kuwahara et al., 2019; Reichman et al., 2017).
In the past decade, transplantation of photoreceptor precursors in retinal degeneration models with a residual outer
nuclear layer (ONL) revealed that donor cells can restore the
function of host retinas through both direct integration
and/or supplying the missing proteins in a phenomenon
called ‘‘material transfer’’ (Barber et al., 2013; Gasparini
et al., 2022; Gonzalez-Cordero et al., 2013; MacLaren et al.,
2006; Ortin-Martinez et al., 2017; Pearson et al., 2012,
2016; Santos-Ferreira et al., 2016; Singh et al., 2013, 2016;
Waldron et al., 2018; Warre-Cornish et al., 2014). ...
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