1.
Vidarsson G, Dekkers G, Rispens T. IgG subclasses and allotypes: from structure to effector functions.
Front Immunol. 2014; 5: 520. https://doi.org/10.3389/fimmu.2014.00520 PMID: 25368619.
2.
Aalberse RC, Stapel SO, Schuurman J, Rispens T. Immunoglobulin G4: an odd antibody. Clin Exp
Allergy. 2009; 39(4): 469–77. Epub 2009/02/19. https://doi.org/10.1111/j.1365-2222.2009.03207.x
PMID: 19222496.
3.
van der Zee JS, van Swieten P, Aalberse RC. Inhibition of complement activation by IgG4 antibodies.
Clin Exp Immunology. 1986; 64(2): 415–422. PMID: 3488859.
4.
van der Neut Kolfschoten M, Schuurman J, Losen M, Bleeker WK, Martı´nez-Martı´nez P, Vermeulen E,
et al. Anti-inflammatory activity of human IgG4 antibodies by dynamic Fab arm exchange. Science.
2007; 317(5844): 1554–1557. https://doi.org/10.1126/science.1144603 PMID: 17872445.
5.
Kanagaratham C, El Ansari YS, Lewis OL, Oettgen HC. IgE and IgG Antibodies as Regulators of Mast
Cell and Basophil Functions in Food Allergy. Front Immunol. 2020; 11: 603050. https://doi.org/10.3389/
fimmu.2020.603050 PMID: 33362785.
6.
Kasperkiewicz M, Ellebrecht CT, Takahashi H, Yamagami J, Zillikens D, Payne AS, et al. Pemphigus.
Nat Rev Dis Primers. 2017; 3: 17026. https://doi.org/10.1038/nrdp.2017.26 PMID: 28492232.
7.
Niks EH, van Leeuwen Y, Leite MI, Dekker FW, Wintzen AR, Wirtz PW, et al. Clinical fluctuations in
MuSK myasthenia gravis are related to antigen-specific IgG4 instead of IgG1. J Neuroimmunol. 2008;
195(1–2): 151–156. Epub 2008/04/04. https://doi.org/10.1016/j.jneuroim.2008.01.013 PMID: 18384886.
Sinkovits G, Szila´gyi A´, Farkas P, Inotai D, Szilva´si A, Tordai A, et al. Concentration and Subclass Distribution of Anti-ADAMTS13 IgG Autoantibodies in Different Stages of Acquired Idiopathic Thrombotic
Thrombocytopenic Purpura. Front Immunol. 2018; 9:1646. https://doi.org/10.3389/fimmu.2018.01646
PMID: 30061898.
8.
9.
Yang Y, Wang C, Jin L, He F, Li C, Gao Q, et al. IgG4 anti-phospholipase A2 receptor might activate lectin and alternative complement pathway meanwhile in idiopathic membranous nephropathy: an inspiration from a cross-sectional study. Immunol Res. 2016; 64(4): 919–930. https://doi.org/10.1007/s12026016-8790-1 PMID: 26837241.
10.
Akdis CA, Akdis M. Mechanisms of allergen-specific immunotherapy and immune tolerance to allergens. World Allergy Organ J. 2015; 8(1): 17. https://doi.org/10.1186/s40413-015-0063-2 PMID:
26023323.
11.
Okamoto S, Taniuchi S, Sudo K, Hatano Y, Nakano K, Shimo T, et al. Predictive value of IgE/IgG4 antibody ratio in children with egg allergy. Allergy Asthma Clin Immuno. 2012; 8(1): 9. https://doi.org/10.
1186/1710-1492-8-9 PMID: 22676477.
12.
Lilienthal GM, Rahmo¨ller J, Petry J, Bartsch YC, Leliavski A, Ehlers M. Potential of Murine IgG1 and
Human IgG4 to Inhibit the Classical Complement and Fcγ Receptor Activation Pathways. Front Immunol. 2018; 9: 958. https://doi.org/10.3389/fimmu.2018.00958 PMID: 29867943.
13.
Anhalt GJ, Labib RS, Voorhees JJ, Beals TF, Diaz LA. Induction of pemphigus in neonatal mice by passive transfer of IgG from patients with the disease. N Engl J Med.1982; 306(20): 1189–1196. https://doi.
org/10.1056/NEJM198205203062001 PMID: 7040962.
14.
Ku¨c¸u¨kerden M, Huda R, Tu¨zu¨n E, Yılmaz A, Skriapa L, Trakas N, et al. MuSK induced experimental
autoimmune myasthenia gravis does not require IgG1 antibody to MuSK. J Neuroimmunol. 2016;295–
296: 84–92. https://doi.org/10.1016/j.jneuroim.2016.04.003 PMID: 27235354.
15.
Shiokawa M, Kodama Y, Kuriyama K, Yoshimura K, Tomono T, Morita T, et al. Pathogenicity of IgG in
patients with IgG4-related disease. Gut. 2016; 65(8): 1322–1332. https://doi.org/10.1136/gutjnl-2015310336 PMID: 26964842.
16.
Bruhns P. Properties of mouse and human IgG receptors and their contribution to disease models.
Blood. 2012; 119(24): 5640–5649. https://doi.org/10.1182/blood-2012-01-380121 PMID: 22535666.
17.
Morse HC, Roths JB 3rd, Davidson WF, Langdon WY, Fredrickson TN, Hartley JW. Abnormalities
induced by the mutant gene, lpr. Patterns of disease and expression of murine leukemia viruses in SJL/
J mice homozygous and heterozygous for lpr. J Exp Med. 1985; 161(3): 602–616. https://doi.org/10.
1084/jem.161.3.602 PMID: 2982991.
18.
Andrews BS, Eisenberg RA, Theofilopoulos AN, Izui S, Wilson CB, McConahey PJ, et al. Spontaneous
murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. J Exp
Med. 1978; 148(5): 1198–1215. https://doi.org/10.1084/jem.148.5.1198 PMID: 309911
PLOS ONE | https://doi.org/10.1371/journal.pone.0279389 February 10, 2023
15 / 16
PLOS ONE
Construction of a human IgG4 knock-in MRL/lpr mice model
19.
Ikehara S, Tanaka H, Nakamura T, Furukawa F, Inoue S, Sekita K, et al. The influence of thymic abnormalities on the development of autoimmune diseases. Thymus. 1985; 7(1): 25–36. PMID: 3871979.
20.
Zou YR, Mu¨ller W, Gu H, Rajewsky K. Cre-loxP-mediated gene replacement: a mouse strain producing
humanized antibodies. Curr Biol. 1994; 4(12): 1099–1103. https://doi.org/10.1016/s0960-9822(00)
00248-7 PMID: 7704573.
21.
Liu L, Takeda K, Akkoyunlu M. Disease Stage-Specific Pathogenicity of CD138 (Syndecan 1)-Expressing T Cells in Systemic Lupus Erythematosus. Front Immunol. 2020; 11: 1569. https://doi.org/10.3389/
fimmu.2020.01569 PMID: 32849532.
22.
Strait RT, Posgai MT, Mahler A, Barasa N, Jacob CO, Ko¨hl J, et al. IgG1 protects against renal disease
in a mouse model of cryoglobulinaemia. Nature. 2015; 517(7535): 501–504. https://doi.org/10.1038/
nature13868 PMID: 25363774.
23.
Shiokawa M, Kodama Y, Sekiguchi K, Kuwada T, Tomono T, Kuriyama K, et al. Laminin 511 is a target
antigen in autoimmune pancreatitis. Sci Trans Med. 2018; 10(453): eaaq0997. https://doi.org/10.1126/
scitranslmed.aaq0997 PMID: 30089633.
24.
Sasaki T, Yajima T, Shimaoka T, Ogawa S, Saito T, Yamaoka K, et al. Synergistic effect of IgG4 antibody and CTLs causes tissue inflammation in IgG4-related disease. Int Immunol. 2020; 32(3): 163–
174. https://doi.org/10.1093/intimm/dxz073 PMID: 31713611.
25.
Konno N, Sugimoto M, Takagi T, Furuya M, Asano T, Sato S, et al. Changes in N-glycans of IgG4 and
its relationship with the existence of hypocomplementemia and individual organ involvement in patients
with IgG4-related disease. PloS one. 2018; 13(4): e0196163. https://doi.org/10.1371/journal.pone.
0196163 PMID: 29672582
26.
Strait RT, Thornton S, Finkelman FD. Cγ1 Deficiency Exacerbates Collagen-Induced Arthritis. Arthritis
Rheumatol. 2016; 68(7): 1780–1787. https://doi.org/10.1002/art.39611 PMID: 26815845.
27.
McGaha TL, Karlsson MC, Ravetch JV. FcgammaRIIB deficiency leads to autoimmunity and a defective response to apoptosis in Mrl-MpJ mice. J Immunol. 2008; 180(8): 5670–5679. https://doi.org/10.
4049/jimmunol.180.8.5670 PMID: 18390752.
28.
Boruchov AM, Heller G, Veri MC, Bonvini E, Ravetch JV, Young JW. Activating and inhibitory IgG Fc
receptors on human DCs mediate opposing functions. J Clin Invest. 2005; 115(10):2914–23. Epub
20050915. https://doi.org/10.1172/JCI24772 PMID: 16167082.
29.
Lemay S, Mao C, Singh AK. Cytokine gene expression in the MRL/lpr model of lupus nephritis. Kidney
Int. 1996; 50(1): 85–93. https://doi.org/10.1038/ki.1996.290 PMID: 8807576.
30.
Nicoletti F, Meroni P, Di Marco R, Barcellini W, Borghi MO, Gariglio M, et al. In vivo treatment with a
monoclonal antibody to interferon-gamma neither affects the survival nor the incidence of lupus-nephritis in the MRL/lpr-lpr mouse. Immunopharmacology. 1992; 24(1): 11–16. https://doi.org/10.1016/01623109(92)90064-j PMID: 1452442.
31.
Karagiannis P, Gilbert AE, Josephs DH, Ali N, Dodev T, Saul L, et al. IgG4 subclass antibodies impair
antitumor immunity in melanoma. J Clin Invest. 2013; 123(4): 1457–1474. https://doi.org/10.1172/
JCI65579 PMID: 23454746.
32.
Bianchini R, Roth-Walter F, Ohradanova-Repic A, Flicker S, Hufnagl K, Fischer MB, et al. IgG4 drives
M2a macrophages to a regulatory M2b-like phenotype: potential implication in immune tolerance.
Allergy. 2019; 74(3): 483–494. https://doi.org/10.1111/all.13635 PMID: 30338531.
PLOS ONE | https://doi.org/10.1371/journal.pone.0279389 February 10, 2023
16 / 16
...