リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

大学・研究所にある論文を検索できる 「養育行動と攻撃行動に関する扁桃体海馬野ニューロンの同定と機能研究」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

コピーが完了しました

URLをコピーしました

論文の公開元へ論文の公開元へ
書き出し

養育行動と攻撃行動に関する扁桃体海馬野ニューロンの同定と機能研究

佐藤, 圭一郎 北海道大学

2023.03.23

概要

哺乳類の親子関係と神経制御
虐待は子どもの生命を脅かすのみならず、精神疾患や情動障害の発生リスクを上昇させ
る ...

この論文で使われている画像

参考文献

1.

Heim, C. & Nemeroff, C. B. The role of childhood

Risk factors for child psychological abuse. Aggress.

trauma in the neurobiology of mood and anxiety

Violent Behav. 6, 189–201 (2001).

disorders: preclinical and clinical studies. Biol.

2.

10.

Psychiatry 49, 1023–1039 (2001).

circuitry for mammalian maternal behavior. Ann. N.

Hughes, K. et al. The effect of multiple adverse

Y. Acad. Sci. 807, 101–125 (1997).

childhood experiences on health: a systematic

3.

11.

neurochemical differentiation of medial preoptic

e356–e366 (2017).

area subregions in relation to maternal behavior in

Widom, C. S., Czaja, S. J., Bentley, T. & Johnson,

the mouse. J. Comp. Neurol. 521, 1633–1663

M. S. A prospective investigation of physical health

(2013).

12.

6.

M. & Dulac, C. G. Galanin neurons in the medial

Health 102, 1135–1144 (2012).

preoptic area govern parental behaviour. Nature 509,

Hovens, J. G. F. M. et al. Childhood life events and

325–330 (2014).

13.

capable of mediating sexually dimorphic behaviors

Psychiatr. Scand. 122, 66–74 (2010).

regardless of gender. Nat. Commun. 9, 279 (2018).

Beitchman, J. H. et al. A review of the long-term

14.

N. X. & Lin, D. A Hypothalamic Midbrain Pathway

101–118 (1992).

Essential for Driving Maternal Behaviors. Neuron

Greene, C. A., Haisley, L., Wallace, C. & Ford, J. D.

98, 192-207.e10 (2018).

15.

Kohl, J. et al. Functional circuit architecture

A systematic review of the parenting practices of

underlying parental behaviour. Nature 556, 326–331

adult survivors of childhood abuse, neglect, and

(2018).

16.

Tsuneoka, Y. et al. Distinct preoptic-BST nuclei

Widom, C. S., Horan, J. & Brzustowicz, L.

dissociate paternal and infanticidal behavior in mice.

Childhood maltreatment predicts allostatic load in

EMBO J. 34, 2652–70 (2015).

adulthood. Child Abus. Negl. 47, 59–69 (2015).

17.

Shinozuka, K. et al. A calcitonin receptor-expressing

Mehta, D. et al. Child Maltreatment and Long-Term

subregion of the medial preoptic area is involved in

Physical and Mental Health Outcomes: An

alloparental tolerance in common marmosets.

Exploration of Biopsychosocial Determinants and

Commun. Biol. 5, 1243 (2022).

Implications for Prevention. Child Psychiatry Hum.

9.

Fang, Y.-Y. Y., Yamaguchi, T., Song, S. C., Tritsch,

effects of child sexual abuse. Child Abuse Negl. 16,

violence. Clin. Psychol. Rev. 80, 101891 (2020).

8.

Wei, Y.-C. C. et al. Medial preoptic area in mice is

anxiety and comorbid disorders vs. controls. Acta

Intergenerational effects of childhood maltreatment:

7.

Wu, Z., Autry, A. E., Bergan, J. F., Watabe-Uchida,

findings from a 30-year follow-up. Am. J. Public

childhood trauma in adult patients with depressive,

5.

Tsuneoka, Y. et al. Functional, anatomical, and

review and meta-analysis. Lancet Public Heal. 2,

outcomes in abused and neglected children: New

4.

Numan, M. & Sheehan, T. P. Neuroanatomical

18.

Sato, K. et al. Amygdalohippocampal Area Neurons

Dev. 1–15 (2021) doi:10.1007/s10578-021-01258-8.

That Project to the Preoptic Area Mediate Infant-

Black, D. A., Smith Slep, A. M. & Heyman, R. E.

Directed Attack in Male Mice. J. Neurosci. 40,

59

3981–3994 (2020).

19.

28.

Kawashima, T. et al. Functional labeling of neurons

subiculum in stress integration. Behav. Brain Res.

and their projections using the synthetic activity–

174, 215–224 (2006).

dependent promoter E-SARE. Nat. Methods 10,

20.

21.

29.

W. E. & Herman, J. P. Central stress-integrative

Sando, R. et al. Inducible control of gene expression

circuits: Forebrain glutamatergic and GABAergic

with destabilized Cre. Nat. Methods 10, 1085–1091

projections to the dorsomedial hypothalamus, medial

(2013).

preoptic area, and bed nucleus of the stria terminalis.

Zhou, X., Vink, M., Klaver, B., Berkhout, B. & Das,

Brain Struct. Funct. 219, 1287–1303 (2014).

30.

in the Posterior Amygdala Gate Territorial

Gene Ther. 13, 1382–1390 (2006).

Aggression. Cell Rep. 31, 107517 (2020).

Loew, R., Heinz, N., Hampf, M., Bujard, H. &

31.

25.

sexual and aggressive behaviors in male mice. Nat.

with minimized background expression. BMC

Neurosci. 23, 1111–1124 (2020).

32.

D. J. Experience-dependent plasticity in an innate

for encoding, retrieval and discrimination of

social behavior is mediated by hypothalamic LTP.

episodic memories. Nat. Rev. Neurosci. 21, 153–168

Proc. Natl. Acad. Sci. 117, 25789–25799 (2020).

33.

Choi, H. M. T. et al. Third-generation in situ

Hasan, M. T. et al. A Fear Memory Engram and Its

hybridization chain reaction: multiplexed,

Plasticity in the Hypothalamic Oxytocin System.

quantitative, sensitive, versatile, robust.

Neuron 103, 133-146.e8 (2019).

Development 145, dev165753 (2018).

Dogbevia, G. K., Marticorena-Alvarez, R., Bausen,

34.

Shen, Y. et al. Molecular cloning and expression of

M., Sprengel, R. & Hasan, M. T. Inducible and

a 5-hydroxytryptamine7 serotonin receptor subtype.

combinatorial gene manipulation in mouse brain.

J. Biol. Chem. 268, 18200–18204 (1993).

35.

Ruat, M. et al. Molecular cloning, characterization,

Dogbevia, G. K., Roßmanith, M., Sprengel, R. &

and localization of a high-affinity serotonin receptor

Hasan, M. T. Flexible, AAV-equipped Genetic

(5-HT7) activating cAMP formation. Proc. Natl.

Modules for Inducible Control of Gene Expression

Acad. Sci. U. S. A. 90, 8547–8551 (1993).

in Mammalian Brain. Mol. Ther. - Nucleic Acids 5,

27.

Stagkourakis, S., Spigolon, G., Liu, G. & Anderson,

Hainmueller, T. & Bartos, M. Dentate gyrus circuits

Front. Cell. Neurosci. 9, 1–8 (2015).

26.

Yamaguchi, T. et al. Posterior amygdala regulates

Gossen, M. Improved Tet-responsive promoters

(2020).

24.

Zha, X. et al. VMHvl-Projecting Vglut1+ Neurons

regulated gene expression through viral evolution.

Biotechnol. 10, 1–13 (2010).

23.

Myers, B., Mark Dolgas, C., Kasckow, J., Cullinan,

889–895 (2013).

A. T. Optimization of the Tet-On system for

22.

Herman, J. P. & Mueller, N. K. Role of the ventral

36.

Ohmura, Y. et al. Serotonin 5-HT7 receptor in the

e309 (2016).

ventral hippocampus modulates the retrieval of fear

Dillingham, B. C. et al. Fear Learning Induces

memory and stress-induced efecation. Int. J.

Long-Lasting Changes in Gene Expression and

Neuropsychopharmacol. 19, 1–12 (2016).

Pathway Specific Presynaptic Growth. bioRxiv

37.

571331 (2019) doi:10.1101/571331.

Santello, M. et al. The brain-penetrant 5-HT7

receptor agonist LP-211 reduces the sensory and

60

affective components of neuropathic pain.

model. Nature 560, 589–594 (2018).

Neurobiol. Dis. 106, 214–221 (2017).

38.

47.

Bijata, M. et al. Activation of the 5-HT7 receptor

and serotonin: Influences on male sexual behavior.

and MMP-9 signaling module in the hippocampal

Physiol. Behav. 83, 291–307 (2004).

CA1 region is necessary for the development of

39.

48.

serotonin hypothesis of aggression revisited. Clin.

Amano, T. et al. Development-dependent behavioral

Psychol. Rev. 17, 651–665 (1997).

49.

Saltzman, W. From here to paternity: Neural

terminalis. Behav. Brain Res. 325, 131–137 (2017).

correlates of the onset of paternal behavior in

Tachikawa, K. S., Yoshihara, Y. & Kuroda, K. O.

California mice (Peromyscus californicus). Horm.

Behavioral transition from attack to parenting in

Behav. 56, 220–231 (2009).

50.

autonomic control in mice lacking brain serotonin.

Wan, J. et al. A genetically encoded sensor for

Proc. Natl. Acad. Sci. U. S. A. 106, 10332–10337

measuring serotonin dynamics. Nat. Neurosci. 24,

(2009).

51.

44.

impaired in female mice lacking type 3 adenylyl

M. & Brownfield, M. Localization of 5-HT7

cyclase. Neuropsychopharmacology 36, 772–781

receptors in rat brain by immunocytochemistry, in

(2011).

52.

Role of cyclic nucleotides and their downstream

Huang, K. W. et al. Molecular and anatomical

signaling cascades in memory function: Being at the

organization of the dorsal raphe nucleus. Elife 8, 1–

right time at the right spot. Neurosci. Biobehav. Rev.

34 (2019).

113, 12–38 (2020).

Mnie-Filali, O. et al. Pharmacological blockade of

53.

McHenry, J. A. et al. Hormonal gain control of a

5-HT 7 receptors as a putative fast acting

medial preoptic area social reward circuit. Nat.

antidepressant strategy. Neuropsychopharmacology

Neurosci. 20, 449–458 (2017).

54.

Park, S.-G. G. et al. Medial preoptic circuit induces

Francesco Ferrari, P., Palanza, P., Parmigiani, S., De

hunting-like actions to target objects and prey. Nat.

Almeida, R. M. M. & Miczek, K. A. Serotonin and

Neurosci. 21, 364–372 (2018).

aggressive behavior in rodents and nonhuman

46.

Argyrousi, E. K., Heckman, P. R. A. & Prickaerts, J.

expression. J. Chem. Neuroanat. 21, 63–73 (2001).

36, 1275–1288 (2011).

45.

Wang, Z. & Storm, D. R. Maternal behavior is

Neumaier, J. F., Sexton, T. J., Yracheta, J., Diaz, A.

situ hybridization, and agonist stimulated cFos

43.

Alenina, N. et al. Growth retardation and altered

J. Neurosci. 33, 5120–5126 (2013).

746–752 (2021).

42.

de Jong, T. R., Chauke, M., Harris, B. N. &

rhomboid nucleus of the bed nucleus of the stria

male mice: a crucial role of the vomeronasal system.

41.

Berman, M. E., Tracy, J. I. & Coccaro, E. F. The

depressive-like behavior. Cell Rep. 38, (2022).

change toward pups and synaptic transmission in the

40.

Hull, E. M., Muschamp, J. W. & Sato, S. Dopamine

55.

Nakamura, K. & Morrison, S. F. Central efferent

primates: Predispositions and plasticity. Eur. J.

pathways for cold-defensive and febrile shivering. J.

Pharmacol. 526, 259–273 (2005).

Physiol. 589, 3641–3658 (2011).

Walsh, J. J. et al. 5-HT release in nucleus

56.

accumbens rescues social deficits in mouse autism

Moffitt, J. R. et al. Molecular, spatial, and functional

single-cell profiling of the hypothalamic preoptic

61

57.

region. Science 362, eaau5324 (2018).

cells using Smart-seq2. Nat. Protoc. 9, 171–181

Dimén, D. et al. Sex-specific parenting and

(2014).

depression evoked by preoptic inhibitory neurons.

62.

iScience 24, 103090 (2021).

58.

59.

aligner. Bioinformatics 29, 15–21 (2013).

Kawai, S., Takagi, Y., Kaneko, S. & Kurosawa, T.

63.

with single-cell RNA-seq data reveals molecular

alternate to ketamine in mice. Exp. Anim. 60, 481–7

properties of light-sensitive neurons in mouse V1.

(2011).

Protein Cell 11, 417–432 (2020).

Sherathiya, V. N., Schaid, M. D., Seiler, J. L.,

64.

Stuart, T. et al. Comprehensive Integration of

Single-Cell Data. Cell 177, 1888-1902.e21 (2019).

toolbox for the analysis of fiber photometry data.

65.

Butler, A., Hoffman, P., Smibert, P., Papalexi, E. &

Sci. Rep. 11, 1–9 (2021).

Satija, R. Integrating single-cell transcriptomic data

Yamauchi, N. et al. Activation of the neural pathway

across different conditions, technologies, and

from the dorsolateral bed nucleus of the stria

species. Nat. Biotechnol. 36, 411–420 (2018).

terminalis to the central amygdala induces anxiety‐

61.

Liu, J. et al. Integrative analysis of in vivo recording

Effect of three types of mixed anesthetic agents

Lopez, G. C. & Lerner, T. N. GuPPy, a Python

60.

Dobin, A. et al. STAR: Ultrafast universal RNA-seq

66.

McInnes, L., Healy, J. & Melville, J. UMAP:

like behaviors. Eur. J. Neurosci. 48, 3052–3061

Uniform Manifold Approximation and Projection

(2018).

for Dimension Reduction. arXiv preprint

Picelli, S. et al. Full-length RNA-seq from single

arXiv:1802.03426 (2018).

62

謝辞

本研究を遂行するにあたりご指導、ご鞭撻を頂きました南雅文 教授、天野大樹 准教授、竹

内雄一 准教授、奥野浩行 教授(鹿児島大学 大学院医歯学総合研究科)、野村洋 寄附講座

教授(名古屋市立大学 大学院医学研究科 脳神経科学研究所)、人羅奈津子 特任助教(熊

本大学 大学院生命科学研究部)に心より感謝いたします。

本研究に関して scRNA-seq の解析について貴重なご指導、ご助言を賜りました東

京大学 大学院新領域創成科学研究科 鈴木穣 教授ならびに文部科学省科学研究費新学術

領域研究ゲノム支援に謹んで感謝の意を表します。

また、日常の議論を通じて多くの知識や示唆を頂きました薬理学研究室の先輩、同

期、後輩の皆様に心より感謝致します。

最後に、これまで長きに渡り私の研究生活を温かく支えて下さいました、家族、親

族、友人に心より感謝致します。

63

...

参考文献をもっと見る

全国の大学の
卒論・修論・学位論文

一発検索!

この論文の関連論文を見る