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Diagnostic utility of the basophil activation test in natto-induced hypersensitivity (本文)

福田, 理紗 慶應義塾大学

2022.06.13

概要

Background: Natto (fermented soybeans)-induced hypersensitivity is characterized by delayed symptom onset that hampers diagnosis. We aimed to clarify the clinical utility of the basophil activation test (BAT) in the diagnosis of natto-induced hypersensitivity.

Methods: Five patients with a history of anaphylaxis and chronic urticaria suspected of natto-induced hypersensitivity and seven with chronic spontaneous urticaria clinically unrelated to natto were enrolled in the patient and control groups, respectively. The BAT was performed with two incubation times, 15 min and 1 h, in combination with various concentrations of natto-mucilage extract.

Results: In controls, CD203c levels in basophils remained low in the 15-min incubation but were significantly increased in the 1-h incubation. In the patient group, in the 15-min condition, basophil CD203c was significantly upregulated by natto mucilage but not by soybean vs controls (P ¼ 0.001). Low concentrations of natto mucilage were sufficient to upregulate basophil CD203c in the anaphylaxis cases, but high concentrations were required to induce the same effect in the urticaria cases. Finally, the dose- dependent pattern of the BAT results differed significantly between the anaphylaxis and urticaria cases (P ¼ 0.006). Thus, a strong background reaction was observed in the BAT with 1 h incubation; 15 min of incubation was sufficient to identify patients with natto-induced hypersensitivity and may distinguish the clinical phenotype of natto-induced hypersensitivity, i.e., anaphylaxis or urticaria.

Conclusions: The BAT with a 15-min incubation period is useful in diagnosing natto-induced hypersensitivity.

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参考文献

1. Parkouda C, Nielsen DS, Azokpota P, Ouoba LI, Amoa-Awua WK, Thorsen L, et al. The microbiology of alkaline-fermentation of indigenous seeds used as food condiments in Africa and Asia. Crit Rev Microbiol 2009;35:139e56.

2. Inomata N, Nomura Y, Ikezawa Z. Involvement of poly (g-glutamic acid) as an allergen in late-onset anaphylaxis due to fermented soybeans (natto). J Dermatol 2012;39:409e12.

3. Inomata N, Osuna H, Ikezawa Z. Late-onset anaphylaxis to Bacillus natto- fermented soybeans (natto). J Allergy Clin Immunol 2004;113:998e1000.

4. Inomata N, Osuna H, Kawano K, Yamaguchi J, Yanagimachi M, Matsukura S, et al. Late-onset anaphylaxis after ingestion of Bacillus Subtilis-fermented soybeans (Natto): clinical review of 7 patients. Allergol Int 2007;56:257e61.

5. Fukuda R, Ouchi T, Shiiya C, Yasuda-Sekiguchi F, Kouno M, Takahashi S, et al. Urticaria due to natto (fermented soybeans). Clin Exp Dermatol 2021;46:932e4.

6. Bernstein IL, Li JT, Bernstein DI, Hamilton R, Spector SL, Tan R, et al. Allergy diagnostic testing: an updated practice parameter. Ann Allergy Asthma Immunol 2008;100:S1e148.

7. Yamakawa K, Inomata N, Fukuro K, Sano S, Nakagawara R, Aihara M. Fer- mented soybean-induced late-onset anaphylaxis in a 7-year-old junior surfer. J Dermatol 2020;47:e17e8.

8. Suzuki K, Futamura K, Sato N, Nakamura M, Matsunaga K, Yagami A. Two cases of fermented soybean (natto) allergy diagnosed using the skin prick test and enzyme linked immunosorbent assay for poly-g-glutamic acid. J Dermatol 2020;47:429e30.

9. Inomata N, Chin K, Aihara M. Anaphylaxis caused by ingesting jellyfish in a subject with fermented soybean allergy: possibility of epicutaneous sensiti- zation to poly-gamma-glutamic acid by jellyfish stings. J Dermatol 2014;41: 752e3.

10. Shih IL, Van YT. The production of poly-(gamma-glutamic acid) from micro- organisms and its various applications. Bioresour Technol 2001;79:207e25.

11. Chettri R, Bhutia MO, Tamang JP. Poly-g-Glutamic acid (PGA)-Producing Ba-cillus species isolated from kinema, Indian fermented soybean food. Front Microbiol 2016;7:971.

12. Cardona V, Ansotegui IJ, Ebisawa M, El-Gamal Y, Fernandez Rivas M, Fineman S, et al. World allergy organization anaphylaxis guidance 2020. World Allergy Organ J 2020;13:100472.

13. Zuberbier T, Aberer W, Asero R, Abdul Latiff AH, Baker D, Ballmer-Weber B, et al. The EAACI/GA2LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria. Allergy 2018;73:1393e414.

14. Inomata N, Chin K, Nagashima M, Ikezawa Z. Late-onset anaphylaxis due to poly (gamma-glutamic acid) in the soup of commercial cold Chinese noodles in a patient with allergy to fermented soybeans (natto). Allergol Int 2011;60: 393e6.

15. Oda Y, Ikkaku N, Horikawa N, Inomata N. [A case of anaphylaxis due to poly gamma-glutamic acid]. [Jpn J Clin Dermatol] 2016;70:558e61 (in Japanese).

16. Lund G, Jacobi H, Skov PS, Holm J, Lund K. Effect on cell surface markers following allergen-induced desensitization of human whole-blood basophils. Int Arch Allergy Immunol 2010;153:323e34.

17. Appel MY, Nachshon L, Elizur A, Levy MB, Katz Y, Goldberg MR. Evaluation of the basophil activation test and skin prick testing for the diagnosis of sesame food allergy. Clin Exp Allergy 2018;48:1025e34.

18. Koplin JJ, Perrett KP, Sampson HA. Diagnosing peanut allergy with fewer oral food challenges. J Allergy Clin Immunol Pract 2019;7:375e80.

19. Kumagai T, Yamaguchi N, Hirai H, Kojima S, Kodani Y, Hashiguchi A, et al. Loxoprofen sodium induces the production of complement C5a in human serum. Int Immunopharmacol 2016;33:55e62.

20. Wensing M, Penninks AH, Hefle SL, Koppelman SJ, Bruijnzeel-Koomen CA, Knulst AC. The distribution of individual threshold doses eliciting allergic re- actions in a population with peanut allergy. J Allergy Clin Immunol 2002;110: 915e20.

21. MacGlashan Jr DW. Basophil activation testing. J Allergy Clin Immunol 2013;132:777e87.

22. Christensen LH, Holm J, Lund G, Riise E, Lund K. Several distinct properties of the IgE repertoire determine effector cell degranulation in response to allergen challenge. J Allergy Clin Immunol 2008;122:298e304.

23. Cromwick AM, Birrer GA, Gross RA. Effects of pH and aeration on gamma-poly(glutamic acid) formation by Bacillus licheniformis in controlled batch fermentor cultures. Biotechnol Bioeng 1996;50:222e7.

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