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〈総説〉穀物や果物等の農作物に含まれる食物アレルゲン

衣笠 芹菜 泉 愛理 福住 綾乃 矢野 えりか 財満 信宏 森山 達哉 近畿大学

2022.03.31

概要

[Synopsis] Food allergy is a hypersensitivity reaction mediated by immunological mechanisms to foods. The causative components are mainly proteins. Foods responsible for causing food allergy include animal foods and plant-based foods, but this article focuses on plant foods and introduces allergens in vegetables, fruits, and crops. And, the diversity of the mechanism in which the food allergy is contracted has been noticed recently. Though the sensitization route has diversity, in recent years, "transdermal sensitization" has been noticed as a new sensitization route. Transdermal sensitization is the invasion of allergen molecule from the skin, and the sensitization is established. There are many unclear points such as the characteristics of the allergen which is easy to be sensitized transdermally, and the elucidation of the details is required. This review introduces the percutaneous sensitization potential of agricultural crops, mainly fruits and soybeans, including our research findings. And using specific antibodies against these allergens, we performed quantitative and qualitative risk variation analysis of allergens in plant food by various treatment, processing method, cultivation method, cultivar, etc. In this review, we also introduce our research findings on these fluctuation analyses.

参考文献

1).

Sicherer SH, Sampson HA. (2018) Food allergy: A review and update on epidemiology, pathogenesis,

diagnosis, prevention, and management. J Allergy Clin Immunol. 141:41-58.

2).

中村 晋、飯倉洋治 (2003) 最新食物アレルギー、永井書店

3).

岸野泰男、菅野道廣(編) (1995) 食物アレルギー、光生館

4).

伊藤武、杉山 純一、米谷 民雄、川本 伸一、西島 基弘(編) (2006) 食品検査とリスク回避のための

防御技術、CMC出版

5).

Yagami T, Haishima Y, Nakamura A, Osuna H, Ikezawa Z. (2000) Digestibility of allergens extracted from

natural rubber latex and vegetable foods. J allergy Clin Immunol. 106:752-762.

6).

Yagami T. (2002) Allergies to Cross-Reactive Plant Proteins. Int Arch Allergy Immunol. 128:271-279.

7).

近藤康人 (2005) 臨床栄養 106(4):444-450.

8).

国民生活センターHP (http://www.kokusen.go.jp/news/data/n-20131205_1.html)

9).

Luud J.W.J.G, Ingrid M.van der M, Marinus J.M.S. (2014) Reducing the incidence of allergy and intolerance

to cereals. Journal of Cereal Science. 59(3):337-353.

10). 中村良 (1987) 食品に起因するアレルギー、化学と生物 25 (11) :739-741.

11). 中村晋,山口道也,大石光雄,葉山隆 (1974) そばアレルギー症の研究 : 第 1 報 そばアレルギー症の

症例について、アレルギー 23(8):548-553,580.

12). 近藤康人 (2018) 食物アレルゲンコンポーネント、アレルギー 67(8):996-1002.

13). 福家辰樹 (2020) 野菜・果物アレルギー 日本小児アレルギー学会誌 34(5):602-611.

14). Tuppo L, Alessandri C, Pomponi D, Picone D, Tamburrini M, Ferrara R, Petriccione M, Mangone I, Palazzo

11

農作物に含まれる食物アレルゲン

衣笠・泉・福住・矢野 ・財満・森山

P, Liso M, Giangrieco I, Crescenzo R, Bernardi ML, Zennaro D, Helmer-Citterich M, Mari A, Ciardiello MA.

Peamaclein--a new peach allergenic protein: similarities, differences and misleading features compared to Pru

p 3. Clin Exp Allergy. 2013 Jan;43(1):128-40.

15). Ebner C., Hoffmann-Sommergruber K., Breiteneder H. (2001) Plant food allergens homologous to

pathogenesis-related proteins. Allergy. 56(67):43-44.

16). Santos A., Ree V R. (2011) Profilins mimickers of allergy or relevant allergens? Int Arch Allergy Immunol.

155(3):191-204.

17). Gao J., Cai R.,Zhou N.(2021) Development of a sensitive and stable chemiluminescent immunoassay for

detection of birch pollen allergic specific IgE based on recombinant Bet v1 protein. J Immunol Methods.

493:113040.

18). Wawrzeńczyk A., Żbikowska-Gotz M., Bartuzi Z.(2020) Sensitisation to lipid transfer proteins in pollen allergic adults with food allergy. Postepy Dermatol Alergol. 37(4):508-512.

19). Palacín A., Rivas A L., Gómez-Casado C., Aguirre J., Tordesillas L., Bartra J., Blanco C., Carrillo T., CuestaHerranz J., Bonny C A J., Flores E., García-Alvarez-Eire G M., García-Nuñez I., Fernández J F., Gamboa P.,

Muñoz R., Sánchez-Monge R., Torres M., Losada V S., Villalba M., Vega F., Parro V., Blanca M., Salcedo G.,

Díaz-Perales A. (2012) The involvement of thaumatin-like proteins in plant food cross-reactivity: a multicenter

study using a specific protein microarray. Multicenter Study PLoS One. 7(9):e44088.

20). Inomata N., Okazaki F., Moriyama T., Nomura Y., Yamaguchi Y., Honjoh T., Kawamura Y., Narita H., Aihara

M. (2014) Identification of peamaclein as a marker allergen related to systemic reactions in peach allergy. Ann

Allergy Asthma Immunol. 112(2):175-177.

21). Inomata N., Miyakawa M., Aihara., M. (2017) High prevalence of sensitization to gibberellin-regulated protein

(peamaclein) in fruit allergies with negative immunoglobulin E reactivity to Bet v 1 homologs and profilin:

Clinical pattern, causative fruits and cofactor effect of gibberellin-regulated protein allergy. J

Dermatol.44(7):735-741.

22). Lack G, Fox, D., Northstone, K., Golding, J. (2003) Factors Associated with the Development of Peanut

Allergy in Childhood. N. Engl. J. Med. 348:977-985.

23). Lack, G. (2008) Epidemiologic risks for food allergy. J. Allergy Clin. Immunol. 121:1331-1336.

24). Inomata, N., Nagashima, M., Hakuta, A., Aihara, M. (2015) Food allergy preceded by contact urticaria due to

the same food: Involvement of epicutaneous sensitization in food allergy. Allergol. Int. 64:73-78.

25). Yagami A., Suzuki K.,Nakamura M., Sano A., Iwata Y., Kobayashi T., Suzuki M., Hara K., Teshima R.,

Matsunaga K. (2015) Case of anaphylactic reaction to soy following percutaneous sensitization by soy-based

ingredients in cosmetic products. J. Dermatol. 42:917-918.

26). Corren, J., Ziegler, F S. (2019) TSLP: from allergy to cancer. Nat Immunol. 12:1603-1609.

27). Cayrol, C., Girard J P. (2017) Interleukin-33 (IL-33): A nuclear cytokine from the IL-1 family. Immunol Rev.

281(1):154-168.

28). Kaplan, H D. (2017) Ontogeny and function of murine epidermal Langerhans cells. Nat Immunol. 18:10681075.

29). Humeniuk, P., Dubiela, P., Hoffmann-Sommergruber K. (2017) Dendritic Cells and Their Role in Allergy:

12

農学部紀要第 55 号 1〜14 (2021)

Uptake, Proteolytic Processing and Presentation of Allergens. Int J Mol Sci. 18:1491.

30). Hussain, M., Borcard, L., Walsh, P K., Rodriguez, P M., Mueller, C., Kim, S B., Kubo, M., Artis, D., Noti, M.

(2018) Basophil-derived IL-4 promotes epicutaneous antigen sensitization concomitant with the development

of food allergy. J Allergy Clin Immunol. 141:223-234.

31). 久保 亮治 (2011) 皮膚バリアとランゲルハンス細胞の動態、日本臨床免疫学会誌 34(2):76-84.

32). Kubo A., Nagano K., Yokouchi M., Sasaki H., Amagai M.(2009) External antigen uptake by Langerhans cells

with reorganization of epidermal tight junction barriers. J Exp Med.206(13):2937-2946.

33). 善本 知広 (2017) 経皮感作食物アレルギーの分子メカニズム:二重抗原暴露仮説の実験的エビデン

ス、アレルギー 66(10):1224-1229.

34). Haenuki Y., Matsushita K., Yumikura SF., Ishi KJ., Kawagoe T., Imoto Y., Fujieda S., Yasuda M., Hisa Y.,

Akira S., Nakanishi K., Yoshimoto T. (2012) A critical role of IL-33 in experimental allergic rhinitis. J Allergy

Clin. Immunol.130(1):184-194.

35). Hsieh, K. Y., Tsai, C. C., Herbert Wu, C. H. & Lin, R. H.(2003) Epicutaneous exposure to protein antigen and

food allergy. Clin. Exp. Allergy. 33:1067-1075.

36). Lehto N., Koivuluhta M., Wang G., Amghaiab I., Majuri ML., Savolainen K., Turjanmaa K., Wolff H., Reunala

T., Lauerma A., Palosuo T., Alenius H. (2003) Epicutaneous natural rubber latex sensitization induces T helper

2-type dermatitis and strong prohevein-specific IgE response. J Invest Dermatol. 120(4):633-640.

37). Scheurer S., Pastorello EA., Wangorsch A., Kästnera M., Haustein D., Vieths S. (2001) Recombinant allergens

Pru av1 and Pru av 4 and a newly identified lipid transfer protein in the in vitro diagnosis of cherry allergy. J.

Allergy Clin. Immunol. 107:724–731.

38). Fierens, E., Gebruers, K., Voet, A.R.D., Maeyer, M.D., Courtin, C.M., Delcour, J.A. (2009) Biochemical and

structural characterization of TLXI, the Triticum aestivum L. thaumatin-like xylanase inhibitor. J Enzyme

Inhib Med Chem. 24:646–654.

39). Smole, U., Bublin, M., Radauer, C., Ebner, C., Breiteneder, H. (2008) Mal d 2, the thaumatin-like allergen

from apple, is highly resistant to gastrointestinal digestion and thermal processing. Int Arch Allergy Immunol.

147:289–298.

40). Mastrorilli, C., Cardinale, F., Giannetti, A., Caffarelli, C. (2019) Pollen-Food Allergy Syndrome: A not so Rare

Disease in Childhood. Medicina (Kaunas). 55:641.

41). Izumi E., Hiroi A., Kinugasa S., Yano E., Zaima N., Moriyama T. (2021) Thaumatin-Like Protein (Pru av 2)

Is a Cherry Allergen That Triggers Percutaneous Sensitization in Mice Foods. 10(1):134.

42). Liu, J., Sturrock, R., Ekramoddoullah, A.K.M. (2010) The superfamily of thaumatin-like proteins: its origin,

evolution, and expression towards biological function. Plant cell Reports. 29:419–436.

43). Kinugasa S., Hidaka S., Tanaka S., Izumi E., Zaima N., Moriyama T. Kiwifruit defense protein, kiwellin (Act

d 5) percutaneously sensitizes mouse models through the epidermal application of crude kiwifruit extract. Food

&Nutr Res. 65: 7610, 2021.

44). Wang J, Vanga SK, McCusker C, Raghavan AV. (2019) Comprehensive Review on Kiwifruit Allergy:

Pathogenesis, Diagnosis, Management, and Potential Modification of Allergens Through Processing.

Comprehensive Reviews in Food Science and Food Safety. 18(2): 500-513.

13

農作物に含まれる食物アレルゲン

衣笠・泉・福住・矢野 ・財満・森山

45). Hamiaux C, Maddumage R, Middleditch MJ, Prakash R, Brummell DA, Baker EN, Atkinson RG.(2014)

Crystal structure of kiwellin, a major cell wall protein from kiwifruit. Journal of Structural Biology. 187(3):

276-281.

46). Maddumage R, Nieuwenhuizen NJ, Bulley SM, Cooney JM, Green SA, Atkinson RG.(2013) Diversity and

Relative Levels of Actinidin, Kiwellin, and Thaumatin-Like Allergens in 15 Varieties of Kiwifruit (Actinidia).

J. Agric. Food Chem. 61(3): 728-739.

47). Cavica M, Grozdanovic MM, Bajic A, Jankovic R, Andjus PR, Gavrovic-Jankulovic M.(2014) The effect of

kiwifruit (Actinidia deliciosa) cysteine protease actinidin on the occludin tight junction network in T84

intestinal epithelial cells. Food Chem. Toxicol. 72: 61-68.

48). Murakami, H., Ogawa T., Takafuta A., Yano E., Zaima N., Moriyama T. (2018) Identification of the 7S and

11S globulins as percutaneously sensitizing soybean allergens as demonstrated through epidermal application

of crude soybean extract. Biosci. Biotech., Biochem. 82:1408-1416.

49). Murakami H., Ogawa T., Takafuta A., Yano E., Zaima N., Moriyama T. (2018) Percutaneous Sensitization to

Soybean Proteins Is Attenuated by Oral Tolerance. J. Nutr. Sci. and Vitaminol. 64(6):683-686.

50). Moriyama T., Yano E., Kitta K., Kawamoto S., Kawamura Y., Todoroki S. (2013) Effect of Gamma-Irradiation

on Soybean Allergen Levels. Biosci. Biotechnol. Biochem., 77:2371-2377.

51). Lua, M.; Jina, Y.; Weber, B.B.; Goodman, R.E. (2018) A comparative study of human IgE binding to proteins

of a genetically modified (GM) soybean and six non-GM soybeans grown in multiple locations. Food Chem.

Toxicol. 112:216–223.

52). Kim, S.H.; Kim, H.M.; Ye, Y.M.; Kim, S.H.; Nahm, D.H.; Park, H.S.; Ryu, S.R.; Lee, B.O.(2006) Evaluating

the Allergic Risk of Genetically Modified Soybean. Yonsei Med. J. 47:505–512.

53). Tsai, J.J.; Chang, C.Y.; Liao, E.C.(2017) Comparison of Allergenicity at Gly m 4 and Gly m Bd 30K of Soybean

after Genetic Modification. J. Agric. Food Chem. 65:1255–1262.

54). Matsuo A., Matsushita K., Fukuzumi A., Tokumasu N., Yano E., Zaima N., Moriyama T. (2020) Comparison

of Various Soybean Allergen Levels in Genetically and Non-Genetically Modified Soybeans. Foods.9(4):522.

55). Hanafusa K., Murakami H., Ueda T., Yano E., Zaima N., Moriyama T. (2018) Worm wounding increases levels

of pollen-related food allergens in soybean (Glycine max). Biosci. Biotechnol. Biochem. 82:1207-1215.

56). 三口志穂・森山達達哉,他 (2015) カビ被害による農作物汎アレルゲン(PR-10,PR-5,プロフィリ

ン)の変動解析、アレルギーの臨床 35(9):64-67.

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