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大学・研究所にある論文を検索できる 「A Prospective Multicenter Observational Study of Venous Thromboembolism after Gastric Cancer Surgery (SHISA-1601).」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

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A Prospective Multicenter Observational Study of Venous Thromboembolism after Gastric Cancer Surgery (SHISA-1601).

KAIDA Sachiko 70710234 0000-0002-1279-5942 MIYAKE Toru 70581924 MURATA Satoshi 90239525 YAMAGUCHI Tsuyoshi 10510290 TATSUTA Takeshi MURAKAMI Koichiro 30572763 OKAUCHI Hiroshi NISHIMURA Shoichi OHTA Hiroyuki 80710459 0000-0002-3318-9263 TSUCHIHASHI Hiroshi KAWASAKI Masayasu TAKEBAYASHI Katsushi SHIMIZU Tomoharu 70402708 0000-0002-2858-0786 TANI Masaji 60236677 0000-0003-1270-6003 滋賀医科大学

2021.03.03

概要

Introduction:
This study aimed to clarify the frequency and risk factors of intercurrent venous thromboembolism (VTE) in patients undergoing major curative gastric cancer surgery.
Methods:
This prospective, multicenter, observational study included patients with gastric cancer who underwent radical gastrectomy at 5 hospitals between June 2016 and May 2018. Patients who were preoperatively administered anticoagulants were excluded.
Results:
A total of 126 patients were eligible to participate. VTE occurred within 9 days postoperatively in 5 cases (4.0%; 2 symptomatic and 3 asymptomatic). Postoperative day (POD) 1 plasma D-dimer and soluble fibrin (SF) levels were significantly higher in the VTE group than in the non-VTE group. Receiver-operating characteristic curve (ROC) analysis indicated a statistically significant ability of POD 1 D-dimer and SF levels to predict postoperative VTE development after gastrectomy; this finding was reflected by an area under the curve (AUC) of 0.97 (95% CI 0.92-1.0) and 0.87 (95% CI 0.74-1.0), respectively. Cutoff values of D-dimer (24.6 µg/mL) and SF (64.1 µg/mL) were determined. Intraoperative blood transfusion (odds ratio [OR] 7.86), POD 1 D-dimer ≥24.6 µg/mL (OR 17.35), and POD 1 SF ≥64.1 µg/mL (OR 19.5) were independent predictive factors for postoperative VTE (p < 0.05).
Conclusion:
VTE occurred in 4.0% patients (1.6% symptomatic and 2.4% asymptomatic) after gastric cancer surgery; however, with an early diagnosis and anticoagulant therapy, no patients experienced progression. Careful observation of patients with a high risk for VTE, including intraoperative blood transfusion and high POD 1 D-dimer or SF levels, would contribute to the early detection of VTE.

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参考文献

1 Prandoni P, Falanga A, Piccioli A. Cancer and venous thromboembolism. Lancet Oncol. 2005 Jun;6(6):401–10.

2 Furie B, Furie BC. Mechanisms of thrombus formation. N Engl J Med. 2008 Aug;359(9):938–49.

3 Varki A. Trousseau’s syndrome: multiple definitions and multiple mechanisms. Blood. 2007 Sep; 110(6):

1723–9.

4 Geerts WH, Bergqvist D, Pineo GF, et al. Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. 2008 Jun;133(6 Suppl):381S–453S.

5 Heit JA, Silverstein MD, Mohr DN, Petterson TM, O’Fallon WM, Melton LJ 3rd. Risk factors for deep vein thrombosis and pulmonary embolism: a population-based case-control study. Arch Intern Med. 2000 Mar;160(6):

809–15.

6 Silverstein MD, Heit JA, Mohr DN, Petterson TM, O’Fallon WM, Melton LJ 3rd. Trends in the incidence of deep

vein thrombosis and pulmonary embolism: a 25-year population-based study. Arch Intern Med. 1998 Mar;

158(6):585–93.

7 Sakon M, Kakkar AK, Ikeda M, Sekimoto M, Nakamori S, Yano M, et al. Current status of pulmonary embolism

in general surgery in Japan. Surg Today. 2004;34(10):805–10.

8 Mismetti P, Laporte S, Darmon JY, Buchmüller A, Decousus H. Meta-analysis of low molecular weight heparin

in the prevention of venous thromboembolism in general surgery. Br J Surg. 2001 Jul;88(7):913–30.

9 Geahchan N, Basile M, Tohmeh M; DIONYS registry. Venous thromboembolism prophylaxis in patients undergoing abdominal and pelvic cancer surgery: adherence and compliance to ACCP guidelines in DIONYS registry.

Springerplus. 2016 Sep;5(1):1541.

10 Lyman GH, Bohlke K, Khorana AA, Kuderer NM, Lee AY, Arcelus JI, et al.; American Society of Clinical Oncology.

Venous thromboembolism prophylaxis and treatment in patients with cancer: american society of clinical

oncology clinical practice guideline update 2014. J Clin Oncol. 2015 Feb;33(6):654–6.

11 Gould MK, Garcia DA, Wren SM, et al. Prevention of VTE in nonorthopedic surgical patients: Antithrombotic

Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical

Practice Guidelines. Chest. 2012 Feb;141(2 Suppl):e227S–e277S.

12 Bang YJ, Van Cutsem E, Feyereislova A, Chung HC, Shen L, Sawaki A, et al.; ToGA Trial Investigators. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive

advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled

trial. Lancet. 2010 Aug;376(9742):687–97.

13 Chang SC, Liu KH, Hung CY, Tsai CY, Hsu JT, Yeh TS, et al. Adjuvant Chemotherapy Improves Survival in Stage

III Gastric Cancer after D2 Surgery. J Cancer. 2018 Jan;9(1):81–91.

14 Tanizawa Y, Bando E, Kawamura T, Tokunaga M, Makuuchi R, Iida K, et al. Prevalence of deep venous thrombosis detected by ultrasonography before surgery in patients with gastric cancer: a retrospective study of

1140 consecutive patients. Gastric Cancer. 2017 Sep;20(5):878–86.

15 Lee KW, Bang SM, Kim S, Lee HJ, Shin DY, Koh Y, et al. The incidence, risk factors and prognostic implications

of venous thromboembolism in patients with gastric cancer. J Thromb Haemost. 2010 Mar;8(3):540–7.

16 Clavien PA, Barkun J, de Oliveira ML, Vauthey JN, Dindo D, Schulick RD, et al. The Clavien-Dindo classification

of surgical complications: five-year experience. Ann Surg. 2009 Aug;250(2):187–96.

17 Niimi R, Hasegawa M, Sudo A, Shi D, Yamada T, Uchida A. Evaluation of soluble fibrin and D-dimer in the diagnosis of postoperative deep vein thrombosis. Biomarkers. 2010 Mar;15(2):149–57.

18 Jung YJ, Seo HS, Park CH, Jeon HM, Kim JI, Yim HW, et al. Venous Thromboembolism Incidence and Prophylaxis

Use After Gastrectomy Among Korean Patients With Gastric Adenocarcinoma: The PROTECTOR Randomized

Clinical Trial. JAMA Surg. 2018 Oct;153(10):939–46.

19 Osaki T, Saito H, Fukumoto Y, Kono Y, Murakami Y, Shishido Y, et al. Risk and incidence of perioperative deep

vein thrombosis in patients undergoing gastric cancer surgery. Surg Today. 2018 May;48(5):525–33.

20 Holbrook A, Schulman S, Witt DM, et al. Evidence-based management of anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based

Clinical Practice Guidelines. Chest. 2012 Feb;141(2 Suppl):e152S–84S.

21 Felder S, Rasmussen MS, King R, et al. Prolonged thromboprophylaxis with low molecular weight heparin for

abdominal or pelvic surgery. Cochrane Database Syst Rev. 2009 Jan 21;(1):CD004318.

22 Riess H, Habbel P, Jühling A, Sinn M, Pelzer U. Primary prevention and treatment of venous thromboembolic

events in patients with gastrointestinal cancers - Review. World J Gastrointest Oncol. 2016 Mar;8(3):258–70.

23 Guyatt GH, Akl EA, Crowther M, et al. Executive summary: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012

Feb;141(2 Suppl):7S–47S.

24 Li M, Guo Q, Hu W. Incidence, risk factors, and outcomes of venous thromboembolism after oncologic surgery:

A systematic review and meta-analysis. Thromb Res. 2019 Jan;173:48–56.

25 Nielsen AW, Helm MC, Kindel T, Higgins R, Lak K, Helmen ZM, et al. Perioperative bleeding and blood transfusion are major risk factors for venous thromboembolism following bariatric surgery. Surg Endosc. 2018

May;32(5):2488–95.

26 Kimura Y, Oki E, Ando K, Saeki H, Kusumoto T, Maehara Y. Incidence of Venous Thromboembolism Following

Laparoscopic Surgery for Gastrointestinal Cancer: A Single-Center, Prospective Cohort Study. World J Surg.

2016 Feb;40(2):309–14.

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