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Graphical Abstract
<Title> Copper-catalyzed Electrophilic Amination: An Umpolung Strategy for New C–N Bond Formations
C–H Amination
<Authors' names> Koji Hirano
δ+
C–B/Si Amination
<Summary> δ–
NX highly chemo- and stereoselective C–N bond forming reactions have been developed.
NH
Nitrogen-umpolung-enabled,
copper-catalyzed
By taking advantage of electrophilic amines, otherwise challenging halogen-compatible amination of organoboron, organosilicon,
and related compounds is achieved. Moreover, the catalytic regio- and enantioselective aminoboration/hydroamination of various
alkenes are also realized.
Cu
Aminoboration
Hydroamination
<Diagram>
C–H Amination
δ–
NH
δ+
NX
Cu
C–B/Si Amination
Aminoboration
Hydroamination
...
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