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大学・研究所にある論文を検索できる 「Immune Evasion Mechanisms of the Zoonotic Protozoan Parasite Toxoplasma Gondii in Mammalian Hosts」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

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Immune Evasion Mechanisms of the Zoonotic Protozoan Parasite Toxoplasma Gondii in Mammalian Hosts

BANDO Hironori FUKUDA Yasuhiro YAMAMOTO Masahiro KATO Kentaro 東北大学

2021.03

概要

Toxoplasma gondii is a zoonotic protozoan pathogen that causes toxoplasmosis, an infectious disease that affects most mammals, including domestic animals, wild animals, and humans. Toxoplasmosis in domestic animals causes miscarriages or stillbirths, resulting in economic losses and posing a challenge in animal husbandry. T. gondii is thus an important pathogen that causes serious animal and public health issues, yet there is still no vaccine or preventative medicine. Therefore, efforts to develop novel treatments for toxoplasmosis and to understand the interaction between the host immune response and the parasite in host cells are essential. We know that interferon-γ (IFN-γ)-induced tryptophan degradation by indole-2,3-dioxygenase (IDO1) plays an important role in the IFN-γ-induced anti-T. gondii response. However, little is known about T. gondii virulence mechanisms targeting IDO1. Therefore, we focused on the T. gondii effector TgGRA15 and analyzed its virulence function and mechanism to antagonize the IDO1-mediated anti-T. gondii response. In this study, we demonstrate that inducible nitric oxide synthase is a key host factor for TgGRA15-dependent disruption of the IDO1-dependent anti-T. gondii response.

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