Allen, M. R. (2017). Preclinical models for skeletal research: How commonly used species mimic (or
don't) aspects of human none. Toxicol Pathol 45, 851-4.
Asanuma, F., Miyata, H., Iwaki, Y., Kimura, M., and Matsumoto, K. (2009). Importance of starting age
for myelotoxicity study in dietary restricted rats. J toxicol Pathol 22, 153-66.
Bertani, T., Poggi, A., Pozzoni, R., Delaini, F., Sacchi, G., Thoua, Y., Mecca, G., Remuzzi, G., and
Donati, M. B. (1982). Adriamycin-in duced nephrotic syndrome in rats. Lab Invest 46, 16–23.
Brighton, C. T. (1987). Longitudinal bone growth: the growth plate and its dysfunctions. Instr Course
Lect 36, 3-25.
Chrysis, D., Ritzen, E. M., and Sävebdahl, L. (2003). Growth retardation induced by dexamethasone is
associated with increased apoptosis of the growth plate chondrocytes. J Endocrinol 176, 331-7.
Cline, J. M. and Maronpot, R. R. (1985). Variations in the histologic distribution of rat bone marrow cells
with respect to age and anatomic site. Toxicol Pathol 13, 349-55.
Comereski, C. R., Peden, W. M., Davidson, T. J., Warner, G. L., Hirth, R. S., and Frantz, J. D. (1994).
BR96-doxorubicin conjugate (BMS 182248) versus doxorubicin: a comparative toxicity assess ment in
rats. Toxicol Pathol 22, 473–88.
Ekblom, M., Fässler, R., Tomasini-Johansson, B., Nilsson, K., and Ekblom, P. (1993). Downregulation
of tenascin expression by glucocorticoids in bone marrow stromal cells and in fibroblasts. J Cell Biol
123, 1037-45.
Even-Zohar, N., Jacob, J., Amariglio, N., Rechavi, G., Potievsky, O., Phillip, M., and Gat-Yablonski, G.
(2008). Nutrition-induced catch-up growth increases hypoxia inducible factor 1α RNA levels in the
growth plate. Bone 42, 505-15.
Farnum, C. E., Lee, A. O., O’hara, K., and Wilsman, N. J. (2003). Effect of short-term fasting on bone
elongation rates: an analysis of catch-up growth in young male rats. Pediatr Res 53, 33-41.
Food and Drug Administration (FDA) (2006): Guidance for industry nonclinical safety evaluation of
pediatric drug products.
https://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm0792
47.pdf (accessed Dec 11, 2019)
Food and Drug Administration (FDA) (2007): Guidance document. Redbook 2000: IV.B.1. General
112
guidelines for designing and conducting toxicity studies. https://www.fda.gov/regulatoryinformation/search-fda-guidance-documents/redbook-2000-ivb1-general-guidelines-designing-andconducting-toxicitystudies#:~:text=When%20designing%20and%20conducting%20toxicity,high%20to%20elicit%20minima
l%20toxic (accessed Jan 6, 2021)
Fossey, S., Vahle, J., Long, P., Schelling, S., Ernst, H., Boyce, R. W., Jolette, J., Bolon, B., Bendele, A.,
Rinke, M., Healy, L., High, W., Roth, D. R., Boyle, M., and Leininger, J. (2016). Nonproliferative and
proliferative lesions of the rat and mouse skeletal tissues (Bones, joints, and teeth). J Toxicol Pathol 29,
49S-103S.
Frazier, K. S., Seely, J. C., Hard, G. C., Betton, G., Burnett, R., Nakatsuji, S., Nishikawa, A., DurchfeldMeyer, B., and Bube, A. (2012). Proliferative and nonproliferative lesions of the rat and mouse urinary
system. Toxicol Pathol 40, 14S-86S.
Frazier, K. S. (2017). Drug-induced physeal abnormalities in preclinical toxicity studies. Toxicol Pathol
45, 869-75.
Friedlaender, G. E., Tross, R. B., Doganis, A. C., Kirkwood, J. M., and Baron, R. (1984). Effects of
chemotherapeutic agents on bone. I. Short-term methotrexate and doxorubicin (adriamycin) treatment in a
rat model. J Bone Joint Surg 66, 602–7.
藤田尚男, 藤田恒夫. (1984). III. 組織 2. 支持組織 B. 軟骨組織. 標準組織学, pp. 141-65.
Fukuda, S. and Matsuoka O. (1979). Maturation process of secondary ossification centers in the rat and
assessment of bone age. Exp Anim 28, 1-9.
Gropp, K. E., Carlson, C. S., Evans, M. G., Bagi, C. M., Reagan, W. J., Hurst, S. I., Shelton, D. L., and
Zorbas, M. A. (2018). Effects of Monoclonal Antibodies against Nerve Growth Factor on Healthy Bone
and Joint Tissues in Mice, Rats, and Monkeys: Histopathologic, Biomarker, and Microcomputed
Tomographic Assessments. Toxicol Pathol 46, 408-20.
林直輝, 山内英子, 佐治重衡. (2015). 乳癌患者におけるアロマターゼ阻害薬と骨粗鬆症. The
bone 28, 429-34.
Heinrichs, C., Colli, M., Yanovski, J. A., Laue, L., Gerstl, N. A., Kramer, A. D., Uyeda, J. A., and Baron,
J. (1997). Effects of fasting on the growth plate: systemic and local mechanisms. Endocrinology 138,
5359-65.
113
Hoch, B. L., Klein, M. J., and Schiller, A. L. (2008). Chapter 26. Bones and joints. Rubin’s pathology 5th
edition (Rubin, R. and Strayer, D. S. eds.), pp. 1083-151, Wolters Kluwer, Philadelphia, US.
International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use
(ICH). (2018). ICH harmonised guideline Nonclinical safety testing in support of development of
paediatric medicines S11 draft version –step 2.
星野雄一. (2006). 運動器疾患のガイドライン策定‐日本整形外科学会の活動‐. Jpn J Rehabil
Med 43, 232-6.
厚生省医薬安全局審査管理課長通知 (1999): 反復投与毒性試験に係るガイドラインの一部改正
について. 医薬審第 655 号. https://www.pmda.go.jp/files/000156632.pdf (accessed Dec 29, 2020)
厚生労働省医薬食品局審査管理課長通知 (2010): 医薬品の臨床試験及び製造販売承認申請のた
めの非臨床安全性試験の実施についてのガイダンスについて. 薬食審査発 0219 第 4 号.
https://www.pmda.go.jp/files/000156948.pdf (accessed Jan 6, 2021)
Kalinyak, J. E., Griffin, C. A., Hamilton, R. W., Bradshaw, J. G., Perlman, A. J., and Hoffman, A. R.
(1989). Developmental and hormonal regulation of glucocorticoid receptor messenger RNA in the rat.
J Clin Invest 84, 1843–8.
Jasty, V., Bare, J.J., Jamison, J.R., Porter, M.C., Kowalski, R.L., Clemens, G.R., Jackson, G.E. Jr., and
Hartnagel, R. E. Jr. (1986). Spontaneous Lesions in the sternum of growing rats. Lab Anim Sci 36, 48-51.
Kalak, R., Zhou, H., Street, J., Day, R. E., Modzelewski, J. R. K., Spies, C. M., Liu, P. Y., Li, G., Dunstan,
C. R., Seibel, M. J. (2009). Endogenous glucocorticoid signalling in osteoblasts is necessary to maintain
normal bone structure in mice. Bone 45, 61-7.
Kaufmann, W., Bolon, B., Bradley, A., Butt, M., Czasch, S., Garman, R. H., George, C., Gröters, S.,
Krinke, G., Little, P., McKay, J., Narama, I., Rao, D., Shibutani, M., and Sills, R. (2012). Proliferative and
nonproliferative lesions of the rat and mouse central and peripheral nervous systems. Toxicol Pathol 40,
87S-157S.
Leininger, J. R. and Riley, M. G. I. (1990). 14. Bones, joints, and synovia. In Pathology of the Fischer rat
(Boorman, G. A., Eustis, S. L., Elwell, M. R., Montgomery, Jr. C. A., and Mackenzie, W. F., eds.), pp.
209-26. Academic press, San Diego, USA.
Levin, S., Semler, D., and Ruben, Z. (1993). Effects of two weeks of feed restriction on some common
114
toxicologic parameters in Sprague-Dawley rats. Toxicol Pathol 21, 1-14.
Longley, D. B., Harkin, D. P., and Johnston P. G. (2003). 5-fluorouracil: mechanisms of action and
clinical strategies. Nat Rev Cancer 3, 330-8.
Macdonald, J. S. (1999). Toxicity of 5-fluorouracil. Oncology 13, 33-34.
松本清. (2020) 幼若動物を用いた安全性試験の現状と課題. RSMP 10, 23-31.
Mettler, F. P., Young, D. M., and Ward, J.M. (1977). Adriamycin-induced cardiotoxicity (Cardiomyopathy
and congestive heart failure) in rats. Cancer Res 37, 2705-13.
Michaud, L. B., and Goodin S. (2006). Cancer-Treatment-Induced Bone Loss, Part 1. Am J Health Syst
Pharm 63, 419-30.
Miyata, H., Asanuma, F., Iwaki, Y., Kimura, M., and Matsumoto, K. (2009). Evaluation of myelotoxicity
in dietary restricted rats. J Toxicol Pathol 22, 53-63.
Moriyama, T., Tsujioka, S., Ohira, T., Nonaka, S., Ikeda, H., Sugiura, H., Tomohiro, M., Samura, K. and
Nishikibe, M. (2008). Effects of reduced food intake on toxicity study parameters in rats. J Toxicol Sci
33, 537-47.
Muskhelishvili, L., Latendresse, J. R., Kodell, R.L, and Henderson, E.B. (2003). Evaluation of cell
proliferation in rat tissues with BrdU, PCNA, Ki-67(MIB-5) immunohistochemistry and in situ
hybridization for histone mRNA. J Histochem Cytochem 51, 1681-8.
永井隆士. (2015). 薬剤性骨粗鬆症の診断と治療. 昭和学士会誌 75, 432-38.
長澤浩平. (2002). ステロイド治療と骨壊死. 日本内科学会雑誌 91, 262-268.
小川純人 (2015). アンドロゲン補充と骨代謝. The bone 28, 445-9.
小澤英浩, 中村浩彰. (2007). 第 2 章 硬組織の構造. 新骨の科学 (須田立雄, 小澤英浩, 高橋榮
明, 田中栄, 中村浩彰, 森諭史 編.), pp. 17-50. 医歯薬出版株式会社, 東京.
Parfitt, A. M., Drezner, M. K., Glorieux, F. H., Kanis, J. A., Malluche, H., Meunier, P. J., Ott, S. M., and
Recker, R. R. (1987). Bone histomor phometry: standardization of nomenclature, symbols, and units.
JBMR 2, 595–610.
Prodinger, PM., Foehr, P., Bürklein, D., Bissinger, O., Pilge, H., Kreutzer, K., von Eisenhart-Rothe, R.,
Tischer, T. (2018). Whole bone testing in small animals: systematic characterization of the mechanical
properties of different rodent bones available for rat fracture models. Eur J Med Res 23, 8.
115
Rana, T., Chakrabarti, A., Freeman, M., Biswas, S. (2013). Doxorubicin-mediated bone loss in breast
cancer bone metastases is driven by an interplay between oxidative stress and induction of TGFβ. PLoS
One 8, e78043.
Renne, R., Brix, A., Harkema, J., Herbert, R., Kittel, B., Lewis, D., March, T., Nagano, K., Pino, M.,
Rittinghausen, S., Rosenbruch, M., Tellier, P., and Wohrmann, T. (2009). Proliferative and
nonproliferative lesions of the rat and mouse respiratory tract. Toxicol Pathol 37, 5S-73S.
Roach, H. I., Mehta G., Oreffo, R. O. C., Clarke, N.M.P., and Cooper C. (2003). Temporal analysis of rat
growth plates: cessation of growth with age despite presence of a physis. J Histochem Cytochem 51, 37383.
関あずさ (1999). 4. 10. 骨・軟骨組織毒性. 毒性学―機能・環境・生体― (藤田正一 編.), pp.
149-151. 朝倉書店, 東京.
Silvestrini, G., Ballanti, P., Patacchioli, F. R., Mocetti, P., Di Grezia, R., Martin Wedard, B., Angelucci,
L., and Bonucci, E. (2000). Evaluation of apoptosis and the glucocorticoid receptor in the cartilage
growth plate and metaphyseal bone cells of rats after high-dose treatment with corticosterone. Bone 26,
33-42.
宗圓聰 (2015).ステロイド性骨粗鬆症の臨床疫学と管理ガイドライン. The bone 28, 383-8.
高折修二 (1999), 第 59 章 副腎皮質ホルモン. グッドマン・ギルマン薬理書 (高折修二 監訳.),
pp. 1925-78. 廣川書店, 東京.
Thompson, A., Han, V. K. M., Yang, K. J. (2004). Differential expression of 11beta-hydroxysteroid
dehydrogenase types 1 and 2 mRNA and glucocorticoid receptor protein during mouse embryonic
development. Steroid Biochem Mol Biol 88, 367-75.
Thoolen, B., Maronpot, R. R., Harada, T., Nyska, A., Rousseaux, C., Nolte, T., Malarkey, D. E.,
Kaufmann, W., Küttler, K., Deschl, U., Nakae, D., Gregson, R., Vinlove, M. P., Brix, A. E,, Singh, B.,
Belpoggi, F., Ward, J. M. (2010). Proliferative and nonproliferative lesions of the rat and mouse
hepatobiliary system. Toxicol Pathol 38, 5S-81S.
Vahle, J. L., Long, G. D., Sandusky, G., Westmore, M., Ma, Y. L., and Sato, M. (2004). Bone neoplasms
in F344 rats given teriparatide [rhPTH (1-34)] are dependent on duration of treatment and dose. Toxicol
Pathol 32, 426-38.
Vahle J.L. (2017). Role of anatomic pathology in skeletal evaluations: Applying INHAND diagnostic
116
criteria. Toxicol Pathol 45, 845-50.
van der Eerden, B. C. J., Karperien, M, and Wit, J. M. (2003). Systemic and local regulation of the growth
plate. Endocr Rev 24, 782-801.
van Leeuwen, B. L., Hartel, R. M., Jansen, H. W. B., Kamps, W. A., and Hoekstra, H. J. (2003). The
effect of chemotherapy on the morphology of the growth plate and metaphysis of the growing skeleton.
EJSO 29, 49-58.
Wallig, M. A., and Keenan, K. P. (2013). Chapter 36. Nutritional toxicologic pathology. In Haschek and
Rousseaux’s handbook of toxicologic pathology (Haschek, W. M., Rousseaux, C. G., Wallig, M. A.,
Bolon, B., Ochoa, R., and Mahler, B. W., eds.), Vol. 2, pp. 1077-121. Academic Press, San Diego, USA.
Weinstein, R. S., Wan, C., Liu, Q., Wang, Y., Almeida, M., O'Brien, C. A., Thostenson, J., Roberson, P.
K., Boskey, A. L., Clemens, T. L., and Manolagas, S. C. (2010). Endogenous glucocorticoids decrease
skeletal angiogenesis, vascularity, hydration, and strength in aged mice. Aging Cell 9, 147-61.
Wood, C. L., Soucek, O., Wong S. C., Zaman, F., Farquharson, C., Savendahl, L., and Ahmed, S. F.
(2018). Animal models to explore the effects of glucocorticoids on skeletal growth and structure. J
Endocrinol 236, R69-R91.
Xian, C. J., Howarth, G. S., Cool, J. C., and Foster, B. K. (2004). Effects of acute 5-fluorouracil
chemotherapy and insulin-like growth factor-I pretreatment on growth plate cartilage and metaphyseal
bone in rats. Bone 35, 739-49.
Xian, C. J., Cool, J. C., Pyragius, T., and Foster, B. K. (2006). Damage and recovery of the bone growth
mechanism in young rats following 5-fluorouracil acute chemotherapy. J Cell Biochem 99, 1688-704.
Young, A. V., Hehn, B. M., Cheng, K. M., and Shah, R. M. (1994). A comparative study on the effects of
5-fluorouracil on glycosaminoglycan synthesis during palate development in quail and hamster. Histol
Histopath 9, 515-23.
Young, B. and Heath, J. W. (2000). 10. Skeletal tissues. In Wheater’s functional histology a text and
colour atlas (Young, B. and Heath, J. W. eds.), pp. 172-92. Churchill Livingstone, Edinburgh, UK.
Young, D. M., Fioravanti, J. L., Olson, H. M., and Prieur, D. J. (1975). Chemical and morphologic
alterations of rabbit bone induced by adriamycin. Calcif Tiss Res 18, 47–63.
117
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