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大学・研究所にある論文を検索できる 「The modified Glasgow prognostic score is a reliable predictor of oncological outcomes in patients with rectal cancer undergoing neoadjuvant chemoradiotherapy」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

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The modified Glasgow prognostic score is a reliable predictor of oncological outcomes in patients with rectal cancer undergoing neoadjuvant chemoradiotherapy

Shimada, Atsushi Matsuda, Takeru Sawada, Ryuichiro Hasegawa, Hiroshi Yamashita, Kimihiro Harada, Hitoshi Urakawa, Naoki Goto, Hironobu Kanaji, Shingo Oshikiri, Taro Kakeji, Yoshihiro 神戸大学

2023.10.10

概要

There has been no reliable marker for predicting oncological outcomes in patients with locally advanced rectal cancer (LARC) undergoing neoadjuvant chemoradiotherapy (NACRT). We retrospectively analyzed 73 patients with LARC who underwent curative surgery after NACRT. The modified Glasgow prognostic score (mGPS) was assessed after NACRT, and clinical outcomes were compared between the high (mGPS = 1 or 2; n = 23) and low (mGPS = 0; n = 50) groups. Body mass index was significantly higher in the low mGPS group. The 5-year disease-free survival (DFS) rate was significantly worse in the high mGPS group than that in the low mGPS group (36.7% vs. 76.6%, p = 0.002). Univariate and multivariate analyses of DFS revealed that mGPS was the most significant predictor (p < 0.001). mGPS appears to be a reliable predictor of oncological outcomes in patients with LARC undergoing NACRT.

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参考文献

1. Benson, A. B. 3rd. et al. Colon cancer, version 1.2017, NCCN clinical practice guidelines in oncology. J. Natl. Compr. Cancer Netw.

15, 370–398 (2017).

2. Bosset, J. F. et al. Chemotherapy with preoperative radiotherapy in rectal cancer. N. Engl. J. Med. 355, 1114–1123 (2006).

3. Gérard, J. P. et al. Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3–4 rectal cancers: Results

of FFCD 9203. J. Clin. Oncol. 24, 4620–4625 (2006).

4. Sauer, R. et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N. Engl. J. Med. 351, 1731–1740 (2004).

5. Glynne-Jones, R. & Hughes, R. Critical appraisal of the “wait and see” approach in rectal cancer for clinical complete responders

after chemoradiation. Br. J. Surg. 99, 897–909 (2012).

6. Maas, M. et al. Wait-and-see policy for clinical complete responders after chemoradiation for rectal cancer. J. Clin. Oncol. 29,

4633–4640 (2011).

7. Cunningham, D. et al. Colorectal cancer. Lancet 375, 1030–1047 (2010).

8. Grade, M., Wolff, H. A., Gaedcke, J. & Ghadimi, B. M. The molecular basis of chemoradiosensitivity in rectal cancer: Implications

for personalized therapies. Langenbecks Arch. Surg. 397, 543–555 (2012).

9. Rödel, C., Hofheinz, R. & Liersch, T. Rectal cancer: State of the art in 2012. Curr. Opin. Oncol. 24, 441–447 (2012).

10. Guthrie, G. J. et al. The systemic inflammation-based neutrophil-lymphocyte ratio: Experience in patients with cancer. Crit. Rev.

Oncol. Hematol. 88, 218–230 (2013).

11. McMillan, D. C. The systemic inflammation-based Glasgow Prognostic Score: A decade of experience in patients with cancer.

Cancer Treat. Rev. 39, 534–540 (2013).

12. McMillan, D. C., Crozier, J. E., Canna, K., Angerson, W. J. & McArdle, C. S. Evaluation of an inflammation-based prognostic score

(GPS) in patients undergoing resection for colon and rectal cancer. Int. J. Colorectal Dis. 22, 881–886 (2007).

13. Dolan, R. D. & McMillan, D. C. The prevalence of cancer associated systemic inflammation: Implications of prognostic studies

using the Glasgow Prognostic Score. Crit. Rev. Oncol. Hematol. 150, 102962 (2020).

14. Tuomisto, A. E., Mäkinen, M. J. & Väyrynen, J. P. Systemic inflammation in colorectal cancer: Underlying factors, effects, and

prognostic significance. World J. Gastroenterol. 25, 4383–4404 (2019).

15. Weiser, M. R. AJCC 8th edition: Colorectal cancer. Ann. Surg. Oncol. 25, 1454–1455 (2018).

16. Matsuda, T. et al. Outcomes and prognostic factors of selective lateral pelvic lymph node dissection with preoperative chemoradiotherapy for locally advanced rectal cancer. Int. J. Colorectal Dis. 33, 367–374 (2018).

17. Hashiguchi, Y. et al. Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2019 for the treatment of colorectal

cancer. Int. J. Clin. Oncol. 25, 1–42 (2020).

18. Forrest, L. M., McMillan, D. C., McArdle, C. S., Angerson, W. J. & Dunlop, D. J. Evaluation of cumulative prognostic scores based

on the systemic inflammatory response in patients with inoperable non-small-cell lung cancer. Br. J. Cancer 89, 1028–1030 (2003).

19. Fan, H. et al. Comparison of the Glasgow Prognostic Score (GPS) and the modified Glasgow Prognostic Score (mGPS) in evaluating the prognosis of patients with operable and inoperable non-small cell lung cancer. J. Cancer Res. Clin. Oncol. 142, 1285–1297

(2016).

20. Ishizuka, M., Nagata, H., Takagi, K. & Kubota, K. Influence of inflammation-based prognostic score on mortality of patients

undergoing chemotherapy for far advanced or recurrent unresectable colorectal cancer. Ann. Surg. 250, 268–272 (2009).

21. Lu, X. et al. Prognostic value of the Glasgow prognostic score in colorectal cancer: A meta-analysis of 9,839 patients. Cancer Manag.

Res. 11, 229–249 (2019).

22. Roncolato, F. T. et al. Validation of the modified Glasgow Prognostic Score (mGPS) in recurrent ovarian cancer (ROC)—Analysis

of patients enrolled in the GCIG Symptom Benefit Study (SBS). Gynecol. Oncol. 148, 36–41 (2018).

23. Sato, R. et al. Preoperative change of modified Glasgow prognostic score after stenting predicts the long-term outcomes of obstructive colorectal cancer. Surg. Today 50, 232–239 (2020).

24. Abe, S. et al. Poor nutrition and sarcopenia are related to systemic inflammatory response in patients with rectal cancer undergoing

preoperative chemoradiotherapy. Int. J. Colorectal Dis. 37, 189–200 (2022).

25. Liu, H. et al. BMI may be a prognostic factor for local advanced rectal cancer patients treated with long-term neoadjuvant chemoradiotherapy. Cancer Manag. Res. 20(12), 10321–10332 (2020).

26. Abdel-Rahman, O. Effect of body mass index on 5-FU-based chemotherapy toxicity and efficacy among patients with metastatic

colorectal cancer; A pooled analysis of 5 randomized trials. Clin. Colorectal Cancer 18(4), e385–e393 (2019).

27. Kalb, M. et al. Influence of body mass index on long-term outcome in patients with rectal cancer—A single centre experience.

Cancers (Basel) 11(5), E609 (2019).

28. Lee, Y. J. et al. Prognostic impact of immunonutritional status changes during preoperative chemoradiation in patients with rectal

cancer. Ann. Coloproctol 32, 208–214 (2016).

29. Park, J. H., McMillan, D. C., Horgan, P. G. & Roxburgh, C. S. The impact of anti-inflammatory agents on the outcome of patients

with colorectal cancer. Cancer Treat. Rev. 40, 68–77 (2014).

30. Guirguis-Blake, J. M., Evans, C. V., Perdue, L. A., Bean, S. I. & Senger, C. A. Aspirin use to prevent cardiovascular disease and

colorectal cancer: Updated evidence report and systematic review for the US Preventive Services Task Force. Jama 327, 1585–1597

(2022).

31. Rothwell, P. M. et al. Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: Analysis of the

time course of risks and benefits in 51 randomised controlled trials. Lancet 379, 1602–1612 (2012).

32. Wang, B. & Huang, Y. Effect of aspirin use on neoadjuvant chemoradiotherapy for rectal cancer: A meta-analysis with trial sequential analysis. J. Cancer Res. Clin. Oncol. 146, 2161–2171 (2020).

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33. Pourlotfi, A. et al. Statin therapy and its association with long-term survival after colon cancer surgery. Surgery 171, 890–896

(2022).

34. Deva, S. & Jameson, M. Histamine type 2 receptor antagonists as adjuvant treatment for resected colorectal cancer. Cochrane

Database Syst. Rev. Cd007814 (2012).

35. Wong, T. X. et al. Effects of perioperative oral nutrition supplementation in Malaysian patients undergoing elective surgery for

breast and colorectal cancers—A randomised controlled trial. Nutrients 14, 615 (2022).

Author contributions

T.M., T.O., and S.K. involved in the conception and design of study. A.S., R.S., and H.H. involved in data collection. A.S., K.Y. and H.H. participated in the analysis and interpretation of data. A.S. wrote the main manuscript.

T.M., H.G., and N.U. were responsible for providing critical revisions. All authors reviewed the manuscript.

Competing interests The authors declare no competing interests.

Additional information

Correspondence and requests for materials should be addressed to T.M.

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