1. Buchwalter A and Hetzer MW: Nucleolar expansion and elevated protein translation in premature aging. Nat Commun 8: 328, 2017.
2. Ruggero D: Revisiting the nucleolus: From marker to dynamic integrator of cancer signaling. Sci Signal 5: pe38, 2012.
3. Montanaro L, Trere D and Derenzini M: Changes in ribosome biogenesis may induce cancer by down-regulating the cell tumor suppressor potential. Biochim Biophysica Acta 1825: 101-110, 2012.
4. Stults DM, Killen MW, Williamson EP, Hourigan JS, Vargas HD, Arnold SM, Moscow JA and Pierce AJ: Human rRNA gene clusters are recombinational hotspots in cancer. Cancer Res 69: 9096-9104, 2009.
5. Negi SS and Brown P: rRNA synthesis inhibitor, CX-5461, activates ATM/ATR pathway in acute lymphoblastic leukemia, arrests cells in G2 phase and induces apoptosis. Oncotarget 6: 18094-18104, 2015.
6. Shibata A and Jeggo P: A historical reflection on our under- standing of radiation-induced DNA double strand break repair in somatic mammalian cells; interfacing the past with the present. Int J Radiat Biol 95: 945-956, 2019.
7. van Gent DC, Hoeijmakers JH and Kanaar R: Chromosomal stability and the DNA double-stranded break connection. Nat Rev Genet 2: 196-206, 2001.
8. Hada M and Georgakilas AG: Formation of clustered DNA damage after high-LET irradiation: A review. J Radiat Res 49: 203-210, 2008.
9. Nakajima NI, Brunton H, Watanabe R, Shrikhande A, Hirayama R, Matsufuji N, Fujimori A, Murakami T, Okayasu R, Jeggo P and Shibata A: Visualisation of gammaH2AX foci caused by heavy ion particle traversal; distinction between core track versus non-track damage. PLoS One 8: e70107, 2013.
10. Hagiwara Y, Niimi A, Isono M, Yamauchi M, Yasuhara T, Limsirichaikul S, Oike T, Sato H, Held KD, Nakano T and Shibata A: 3D-structured illumination microscopy reveals clustered DNA double-strand break formation in widespread γH2AX foci after high LET heavy-ion particle radiation. Oncotarget 8: 109370-109381, 2017.
11. Hagiwara Y, Oike T, Niimi A, Yamauchi M, Sato H, Limsirichaikul S, Held KD, Nakano T and Shibata A: Clustered DNA double-strand break formation and the repair pathway following heavy-ion irradiation. J Radiat Res 60: 69-79, 2019.
12. Amornwichet N, Oike T, Shibata A, Ogiwara H, Tsuchiya N, Yamauchi M, Saitoh Y, Sekine R, Isono M, Yoshida Y, et al: Carbon-ion beam irradiation kills X-ray-resistant p53-null cancer cells by inducing mitotic catastrophe. PLoS One 9: e115121, 2014.
13. Durante M and Cucinotta FA: Heavy ion carcinogenesis and human space exploration. Nat Rev Cancer 8: 465-472, 2008.
14. Henderson AS, Warburton D and Atwood KC: Location of ribosomal DNA in the human chromosome complement. Proc Natl Acad Sci USA 69: 3394-3398, 1972.
15. Durkin SG and Glover TW: Chromosome fragile sites. Annu Rev Genet 41: 169-192, 2007.
16. Montgomery PO, Karney D, Reynolds RC and McClendon D: Cellular and subcellular effects of ionizing radiations. Am J Pathol 44: 727-746, 1964.
17. Hidvegi EJ, Holland J, Boloni E, Lonai P, Antoni F and Varteresz V: The effect of whole-body x-irradiation of guinea pigs on liver ribosomes. Biochem J 109: 495-505, 1968.
18. Shibata A, Conrad S, Birraux J, Geuting V, Barton O, Ismail A, Kakarougkas A, Meek K, Taucher-Scholz G, Löbrich M and Jeggo PA: Factors determining DNA double-strand break repair pathway choice in G2 phase. EMBO J 30: 1079-1092, 2011.
19. Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25: 402-408, 2001.
20. Ohno T: Particle radiotherapy with carbon ion beams. EPMA J 4: 9, 2013.
21. Oike T, Niimi A, Okonogi N, Murata K, Matsumura A, Noda SE, Kobayashi D, Iwanaga M, Tsuchida K, Kanai T, et al: Visualization of complex DNA double-strand breaks in a tumor treated with carbon ion radiotherapy. Sci Rep 6: 22275, 2016.
22. Niimi A, Yamauchi M, Limsirichaikul S, Sekine R, Oike T, Sato H, Suzuki K, Held KD, Nakano T and Shibata A: Identification of DNA double strand breaks at chromosome boundaries along the track of particle irradiation. Genes Chromosomes Cancer 55: 650-660, 2016.
23. Petrov AS, Bernier CR, Gulen B, Waterbury CC, Hershkovits E, Hsiao C, Harvey SC, Hud NV, Fox GE, Wartell RM and Williams LD: Secondary structures of rRNAs from all three domains of life. PLoS One 9: e88222, 2014.
24. Lobrich M, Shibata A, Beucher A, Fisher A, Ensminger M, Goodarzi AA, Barton O and Jeggo PA: gammaH2AX foci analysis for monitoring DNA double-strand break repair: Strengths, limi- tations and optimization. Cell Cycle 9: 662-669, 2010.
25. Powell S and McMillan TJ: DNA damage and repair following treatment with ionizing radiation. Radiother Oncol 19: 95-108, 1990.
26. Vilenchik MM and Knudson AG: Endogenous DNA double-strand breaks: Production, fidelity of repair, and induction of cancer. Proc Natl Acad Sci USA 100: 12871-12876, 2003.
27. Amundson SA, Myers TG and Fornace AJ Jr: Roles for p53 in growth arrest and apoptosis: Putting on the brakes after genotoxic stress. Oncogene 17: 3287-3299, 1998.
28. Fenech M, Kirsch-Volders M, Natarajan AT, Surralles J, Crott JW, Parry J, Norppa H, Eastmond DA, Tucker JD and Thomas P: Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells. Mutagenesis 26: 125-132, 2011.
29. Huang H, Fletcher L, Beeharry N, Daniel R, Kao G, Yen TJ and Muschel RJ: Abnormal cytokinesis after x-irradiation in tumor cells that override the G2 DNA damage checkpoint. Cancer Res 68: 3724-3732, 2008.
30. Johmura Y, Shimada M, Misaki T, Naiki-Ito A, Miyoshi H, Motoyama N, Ohtani N, Hara E, Nakamura M, Morita A, et al: Necessary and sufficient role for a mitosis skip in senescence induction. Mol Cell 55: 73-84, 2014.
31. James A, Wang Y, Raje H, Rosby R and DiMario P: Nucleolar stress with and without p53. Nucleus 5: 402-426, 2014.
32. Takagi M, Absalon MJ, McLure KG and Kastan MB: Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Cell 123: 49-63, 2005.