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大学・研究所にある論文を検索できる 「Ibandronate Suppresses Changes in Apatite Orientation and Young's Modulus Caused by Estrogen Deficiency in Rat Vertebrae」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。
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Ibandronate Suppresses Changes in Apatite Orientation and Young's Modulus Caused by Estrogen Deficiency in Rat Vertebrae

Ishimoto, Takuya 大阪大学

2022.01.06

概要

Bone material quality is important for evaluating the mechanical integrity of diseased and/or medically treated bones. How- ever, compared to the knowledge accumulated regarding changes in bone mass, our understanding of the quality of bone material is lacking. In this study, we clarified the changes in bone material quality mainly characterized by the preferential orientation of the apatite c-axis associated with estrogen deficiency-induced osteoporosis, and their prevention using iban- dronate (IBN), a nitrogen-containing bisphosphonate. IBN effectively prevented bone loss and degradation of whole bone strength in a dose-dependent manner. The estrogen-deficient condition abnormally increased the degree of apatite orientation along the craniocaudal axis in which principal stress is applied; IBN at higher doses played a role in maintaining the normal orientation of apatite but not at lower doses. The bone size-independent Young's modulus along the craniocaudal axis of the anterior cortical shell of the vertebra showed a significant and positive correlation with apatite orientation; therefore, the craniocaudal Young’s modulus abnormally increased under estrogen-deficient conditions, despite a significant decrease in volumetric bone mineral density. However, the abnormal increase in craniocaudal Young's modulus did not compensate for the degradation of whole bone mechanical properties due to the bone loss. In conclusion, it was clarified that changes in the material quality, which are hidden in bone mass evaluation, occur with estrogen deficiency-induced osteoporosis and IBN treatment. Here, IBN was shown to be a beneficial drug that suppresses abnormal changes in bone mechanical integrity caused by estrogen deficiency at both the whole bone and material levels.

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参考文献

1. Anastasilakis AD, Polyzos SA, Yavropoulou MP, Makras P (2020) Combination and sequential treatment in women with postmeno- pausal osteoporosis. Expert Opin Pharmacother 21:477–490. https://doi.org/10.1080/14656566.2020.1717468

2. Global Osteoporosis Drugs Market Size, Share, Development, Growth and Demand Forecast to 2022 – Industry Insights by Drug Class (Bisphosphonates, Parathyroid Hormone Therapy, Selective Estrogen Receptor Modulators, Rank Ligand Inhibitor, Calcitonin and Others. https://www.psmarketresearch.com/market-analysis/ osteoporosis-drugs-market. Accessed 20 Oct, 2021

3. Rogers MJ, Mönkkönen J, Munoz MA (2020) Molecular mecha- nisms of action of bisphosphonates and new insights into their effects outside the skeleton. Bone 139:115493. https://doi.org/10. 1016/j.bone.2020.115493

4. Lotz EM, Lohmann CH, Boyan BD, Schwartz Z (2020) Bisphos- phonates inhibit surface-mediated osteogenesis. J Biomed Mater Res A 108:1774–1786. https://doi.org/10.1002/jbm.a.36944

5. Bauss F, Dempster DW (2007) Effects of ibandronate on bone quality: preclinical studies. Bone 40:265–273. https://doi.org/10. 1016/j.bone.2006.08.002

6. Nakamura T, Ito M, Hashimoto J, Shinomiya K, Asao Y, Kat- sumata K, Hagino H, Inoue T, Nakano T, Mizunuma H (2015) Clinical efficacy and safety of monthly oral ibandronate 100 mg versus monthly intravenous ibandronate 1 mg in Japanese patients with primary osteoporosis. Osteoporos Int 26:2685–2693. https:// doi.org/10.1007/s00198-015-3175-1

7. Burr DB (2020) Fifty years of bisphosphonates: What are their mechanical effects on bone? Bone 138:115518. https://doi.org/10. 1016/j.bone.2020.115518

8. Yamagami Y, Mashiba T, Iwata K, Tanaka M, Nozaki K, Yama- moto T (2013) Effects of minodronate and alendronate on bone remodeling, microdamage accumulation, degree of mineralization and bone mechanical properties in ovariectomized cynomolgus monkeys. Bone 54:1–7. https://doi.org/10.1016/j.bone.2013.01. 016

9. Mashiba T, Saito M, Yamagami Y, Tanaka M, Iwata K, Yamamoto T (2017) Effects of suppressed bone remodeling by minodronate and alendronate in bone mass, microdamage accumulation, colla- gen crosslinks and bone mechanical properties in the lumbar ver- tebra of ovariectomized cynomolgus monkeys. Bone 97:184–191. https://doi.org/10.1016/j.bone.2017.01.008

10. Allen MR, Burr DB (2011) Bisphosphonate effects on bone turno- ver, microdamage, and mechanical properties: what we think we know and what we know that we don’t know. Bone 49:56–65. https://doi.org/10.1016/j.bone.2010.10.159

11. Boivin G, Chavassieux PM, Santora AC, Yates J, Meunier PJ (2000) Alendronate increases bone strength by increasing the mean degree of mineralization of bone tissue in osteoporotic women. Bone 27:687–694. https://doi.org/10.1016/S8756- 3282(00)00376-8

12. Yerramshetty JS, Akkus O (2008) The associations between min- eral crystallinity and the mechanical properties of human cortical bone. Bone 42:476–482. https://doi.org/10.1016/j.bone.2007.12. 001

13. Saito M, Marumo K (2010) Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus. Osteoporos Int 21:195–214. https://doi.org/10.1007/s00198-009-1066-z

14. Ishimoto T, Sato B, Lee J-W, Nakano T (2017) Co-deteriorations of anisotropic extracellular matrix arrangement and intrinsic mechanical property in c-src deficient osteopetrotic mouse femur. Bone 103:216–223. https://doi.org/10.1016/j.bone.2017.06.023

15. Sekita A, Matsugaki A, Ishimoto T, Nakano T (2016) Synchro- nous disruption of anisotropic arrangement of the osteocyte net- work and collagen/apatite in melanoma bone metastasis. J Struct Biol 197:260–270. https://doi.org/10.1016/j.jsb.2016.12.003

16. Nakano T, Kaibara K, Tabata Y, Nagata N, Enomoto S, Marukawa E, Umakoshi Y (2002) Unique alignment and texture of biological apatite crystallites in typical calcified tissues analyzed by micro- beam X-ray diffractometer system. Bone 31:479–487. https://doi. org/10.1016/S8756-3282(02)00850-5

17. Landis WJ (1995) The strength of a calcified tissue depends in part on the molecular structure and organization of its constituent mineral crystals in their organic matrix. Bone 16:533–544. https:// doi.org/10.1016/8756-3282(95)00076-P

18. Viswanath B, Raghavan R, Ramamurty U, Ravishanka N (2007) Mechanical propertiesand anisotropy in hydroxyapatite single crystals. Scr Mater 57:361–364. https://doi.org/10.1016/j.scrip tamat.2007.04.027

19. Tanaka Y, Kubota A, Matsusaki M, Duncan T, Hatakeyama Y, Fukuyama K, Quantock AJ, Yamato M, Akashi M, Nishida K (2011) Anisotropic mechanical propertiesof collagen hydrogels induced by uniaxial-flow for ocular applications. J Biomater Sci Polym Ed 22:1427–1442. https://doi.org/10.1163/092050610X 510542

20. Wilke HJ, Kettler A, Wenger KH, Claes LE (1997) Anatomy of the sheep spine and its comparison to the human spine. Anat Rec 247:542–555. https://doi.org/10.1002/(SICI)1097-0185(199704) 247:4%3c542::AID-AR13%3e3.0.CO;2-P

21. Ozasa R, Ishimoto T, Miyabe S, Hashimoto J, Hirao M, Yoshi- kawa H, Nakano T (2019) Osteoporosis changes collagen/apa- tite orientation and Young’s modulus in vertebral cortical bone of rat. Calcif Tissue Int 104:449–460. https://doi.org/10.1007/ s00223-018-0508-z

22. Moriishi T, Ozasa R, Ishimoto T, Nakano T, Hasegawa T, Miyazaki T, Liu W, Fukuyama R, Wang Y, Komori H, Qin X, Amizuka N, Komori T (2020) Osteocalcin is necessary for the alignment of apatite crystallites, but not glucose metabolism, tes- tosterone synthesis, or muscle mass. PLoS Getet 16:e1008586. https://doi.org/10.1371/journal.pgen.1008586

23. Bouxsein ML, Boyd SK, Christiansen BA, Guldberg RE, Jepsen KJ, Müller R (2010) Guidelines for assessment of bone micro- structure in rodents using micro–computed tomography. J Bone Miner Res 25:1468–1486. https://doi.org/10.1002/jbmr.141

24. Ishimoto T, Nakano T, Umakoshi Y, Yamamoto M, Tabata Y (2013) Degree of biological apatite c-axis orientation rather than bone mineral density controls mechanical function in bone regen- erated using recombinant bone morphogenetic protein-2. J Bone Miner Res 28:1170–1179. https://doi.org/10.1002/jbmr.1825

25. Wakamatsu T, Iwasaki Y, Yamamoto S, Matsuo K, Goto S, Narita I, Kazama JJ, Tanaka K, Ito A, Ozasa R, Nakano T, Miyakoshi C, Onishi Y, Fukuma S, Fukuhara S, Yamato H, Fukagawa M, Akizawa T (2021) Type-I angiotensin II receptor blockade reduces uremia-induced deterioration of bone material properties. J Bone Miner Res 36:67–79. https://doi.org/10.1002/jbmr.4159

26. Londoño-Restrepo SM, Jeronimo-Cruz R, Millán-Malo BM, Rivera-Muñoz EM, Rodriguez-García ME (2019) Effect of the nano crystal size on the X-ray diffraction patterns of biogenic hydroxyapatite from human, bovine, and porcine bones. Sci Rep 9:5915. https://doi.org/10.1038/s41598-019-42269-9

27. Rittweger J, Michaelis I, Giehl M, Wüsecke P, Felsenberg D (2004) Adjusting for the partial volume effect in cortical bone analyses of pQCT images. J Musculoskel Neuron Interact 4:436–441

28. Rho JY, Pharr GM (1999) Effects of drying on the mechanical properties of bovine femur measured by nanoindentation. J Mater Sci Mater Med 10:485–488. https://doi.org/10.1023/A:10089 01109705

29. Ishimoto T, Nakano T, Yamamoto M, Tabata Y (2011) Biome- chanical evaluation of regenerating long bone by nanoindenta- tion. J Mater Sci Mater Med 22:969–976. https://doi.org/10.1007/ s10856-011-4266-y

30. Zhu L, Zhao X, Lu X (2009) Ovariectomy-associated changes in bone mineral density and bone marrow haematopoiesis in rats. Int J Exp Pathol 90:512–519. https://doi.org/10.1111/j.1365-2613. 2009.00661.x

31. Bauss F, Lalla S, Endele R, Hothorn LA (2002) Effects of treat- ment with ibandronate on bone mass, architecture, biomechanical properties, and bone concentration of ibandronate in ovariecto- mized aged rats. J Rheumatol 29:2200–2208. https://doi.org/10. 1016/j.bone.2015.08.004

32. Smith SY, Recker RR, Hannan M, Müller R, Bauss F (2003) Intermittent intravenous administration of the bisphosphonate ibandronate prevents bone loss and maintains bone strength and quality in ovariectomized cynomolgus monkeys. Bone 32:45–55. https://doi.org/10.1016/S8756-3282(02)00923-7

33. Monier-Faugere MC, Geng Z, Paschalis EP, Qi Q, Arnala I, Bauss F, Boskey AL, Malluche HH (1999) Intermittent and continuous administration of the bisphosphonate ibandronate in ovariohyster- ectomized beagle dogs: effects on bone morphometry and mineral properties. J Bone Miner Res 14:1768–1778. https://doi.org/10. 1359/jbmr.1999.14.10.1768

34. Launey ME, Buehler MJ, Ritchie RO (2010) On the mechanis- tic origins of toughness in bone. Ann Rev Mater Res 40:25–53. https://doi.org/10.1146/annurev-matsci-070909-104427

35. Wang J, Zhou B, Liu XS, Fields AJ, Sanyal A, Shi X, Adams M, Keaveny TM, Guo XE (2015) Trabecular plates and rods deter- mine elastic modulus and yield strength of human trabecular bone. Bone 72:71–80. https://doi.org/10.1016/j.bone.2014.11.006

36. Homminga J, Van-Rietbergen B, Lochmüller EM, Weinans H, Eckstein F, Huiskes R (2004) The osteoporotic vertebral structure is well adapted to the loads of daily life, but not to infrequent “error” loads. Bone 34:510–516. https://doi.org/10.1016/j.bone. 2003.12.001

37. Ishimoto T, Kawahara K, Matsugaki A, Kamioka H, Nakano T (2021) Quantitative evaluation of osteocyte morphology and bone anisotropic extracellular matrix in rat femur. Calcif Tissue Int 109:434–444. https://doi.org/10.1007/s00223-021-00852-1

38. Wang J, Ishimoto T, Nakano T (2017) Unloading-induced deg- radation of the anisotropic arrangement of collagen/apatite in rat femurs. Calcif Tissue Int 100:87–97. https://doi.org/10.1007/ s00223-016-0200-0

39. Mie K, Ishimoto T, Okamoto M, Iimori Y, Ashida K, Yoshizaki K, Nishida H, Nakano T, Akiyoshi H (2020) Impaired bone quality characterized by apatite orientation under stress shielding follow- ing fixing of a fracture of the radius with a 3D printed Ti-6Al- 4V custom-made bone plate in dogs. PLoS ONE 15:e0237678. https://doi.org/10.1371/journal.pone.0237678

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