Alexander, M., Ramstead, A.G., Bauer, K.M., Lee, S.H., Runtsch, M.C., Wallace, J.,Huffaker, T.B., Larsen, D.K., Tolmachova, T., Seabra, M.C., Round, J.L., Ward, D.M., O’Connell, R.M., 2017. Rab27-dependent exosome production inhibits chronic in- flammation and enables acute responses to inflammatory stimuli. J. Immunol. 199, 3559–3570.
Cheng, C.I., Chen, P.H., Lin, Y.C., Kao, Y.H., 2015. High glucose activates Raw264.7 macrophages through RhoA kinase-mediated signaling pathway. Cell Signal 27, 283–292.
Deng, Y., Wang, J., Huang, M., Xu, G., Wei, W., Qin, H., 2019. Inhibition of miR-148a-3p resists hepatocellular carcinoma progress of hepatitis C virus infection through sup- pressing c-Jun and MAPK pathway. J. Cell Mol. Med. 23, 1415–1426.
Dweep, H., Gretz, N., 2015. miRWalk2.0: a comprehensive atlas of microRNA-target in- teractions. Nat. Methods 12, 697.
Gong, J., Guan, L., Tian, P., Li, C., Zhang, Y., 2018. Rho kinase type 1 (ROCK1) promotes lipopolysaccharide-induced inflammation in corneal epithelial cells by activating toll- like receptor 4 (TLR4)-mediated signaling. Med. Sci. Monit. 24, 3514–3523.
Harrill, A.H., McCullough, S.D., Wood, C.E., Kahle, J.J., Chorley, B.N., 2016. MicroRNA biomarkers of toxicity in biological matrices. Toxicol. Sci. 152, 264–272.
Hirsova, P., Ibrahim, S.H., Krishnan, A., Verma, V.K., Bronk, S.F., Werneburg, N.W., Charlton, M.R., Shah, V.H., Malhi, H., Gores, G.J., 2016. Lipid-induced signaling causes release of inflammatory extracellular vesicles from hepatocytes.Gastroenterology 150, 956–967.
Holman, N.S., Church, R.J., Nautiyal, M., Rose, K.A., Thacker, S.E., Otieno, M.A., Wolf, K.K., LeCluyse, E., Watkins, P.B., Mosedale, M., 2019. Hepatocyte-derived exosomes promote liver immune tolerance: possible implications for idiosyncratic drug-induced liver injury. Toxicol. Sci. 170, 499–508.
Hong, F., Jaruga, B., Kim, W.H., Radaeva, S., El-Assal, O.N., Tian, Z., Nguyen, V.A., Gao, B., 2002. Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: regulation by SOCS. J. Clin. Invest. 110, 1503–1513.
Hou, R., Han, Y., Fei, Q., Gao, Y., Qi, R., Cai, R., Qi, Y., 2018. Dietary flavone tectochrysin exerts anti-inflammatory action by directly inhibiting MEK1/2 in LPS-primed mac- rophages. Mol. Nutr. Food Res. 62.
Huang, d.W., Sherman, B.T., Lempicki, R.A., 2009. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 37, 1–13.
Huang, H.Y., Lin, Y.C., Li, J., Huang, K.Y., Shrestha, S., Hong, H.C., Tang, Y., Chen, Y.G.,Jin, C.N., Yu, Y., Xu, J.T., Li, Y.M., Cai, X.X., Zhou, Z.Y., Chen, X.H., Pei, Y.Y., Hu, L.,Su, J.J., Cui, S.D., Wang, F., Xie, Y.Y., Ding, S.Y., Luo, M.F., Chou, C.H., Chang, N.W.,Chen, K.W., Cheng, Y.H., Wan, X.H., Hsu, W.L., Lee, T.Y., Wei, F.X., Huang, H.D.,2020. miRTarBase 2020: updates to the experimentally validated microRNA-target interaction database. Nucleic Acids Res. 48, D148–D154.
Ikeda, A., Hasegawa, K., Masaki, M., Moriguchi, T., Nishida, E., Kozutsumi, Y., Oka, S., Kawasaki, T., 2001. Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway. J. Biochem. 130, 773–781.
Imai, T., Takahashi, Y., Nishikawa, M., Kato, K., Morishita, M., Yamashita, T., Matsumoto, A., Charoenviriyakul, C., Takakura, Y., 2015. Macrophage-dependent clearance of systemically administered B16BL6-derived exosomes from the blood circulation in mice. J. Extracell. Vesicles 4, 26238.
Laemmli, U.K., 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680–685.
Lawrie, C.H., Gal, S., Dunlop, H.M., Pushkaran, B., Liggins, A.P., Pulford, K., Banham, A.H., Pezzella, F., Boultwood, J., Wainscoat, J.S., Hatton, C.S., Harris, A.L., 2008. Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma. Br. J. Haematol. 141, 672–675.
Li, P., Yao, Y., Ma, Y., Chen, Y., 2019. MiR-150 attenuates LPS-induced acute lung injury via targeting AKT3. Int. Immunopharmacol. 75, 105794.
Liu, C., Cheng, Z., Wang, Y., Dai, X., Zhang, J., Xue, D., 2015. Paeoniflorin exerts a ne- phroprotective effect on concanavalin A-induced damage through inhibition of macrophage infiltration. Diagn. Pathol. 10, 120.
Marukawa, Y., Nakamoto, Y., Kakinoki, K., Tsuchiyama, T., Iida, N., Kagaya, T., Sakai, Y., Naito, M., Mukaida, N., Kaneko, S., 2012. Membrane-bound form of monocyte che- moattractant protein-1 enhances antitumor effects of suicide gene therapy in a model of hepatocellular carcinoma. Cancer Gene Ther. 19, 312–319.
Masaki, M., Ikeda, A., Shiraki, E., Oka, S., Kawasaki, T., 2003. Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically. Eur. J. Biochem. 270, 76–83.
McDonald, M.K., Tian, Y., Qureshi, R.A., Gormley, M., Ertel, A., Gao, R., Aradillas Lopez, E., Alexander, G.M., Sacan, A., Fortina, P., Ajit, S.K., 2014. Functional significance of macrophage-derived exosomes in inflammation and pain. Pain 155, 1527–1539.
Menasche, G., Feldmann, J., Houdusse, A., Desaymard, C., Fischer, A., Goud, B., de Saint Basile, G., 2003. Biochemical and functional characterization of Rab27a mutations occurring in Griscelli syndrome patients. Blood 101, 2736–2742.
Momen-Heravi, F., Bala, S., Kodys, K., Szabo, G., 2015. Exosomes derived from alcohol- treated hepatocytes horizontally transfer liver specific miRNA-122 and sensitize monocytes to LPS. Sci. Rep. 5, 9991.
Oda, S., Takeuchi, M., Akai, S., Shirai, Y., Tsuneyama, K., Yokoi, T., 2018. miRNA in rat liver sinusoidal endothelial cells and hepatocytes and application to circulating biomarkers that discern pathogenesis of liver injuries. Am. J. Pathol. 188, 916–928.
Ostrowski, M., Carmo, N.B., Krumeich, S., Fanget, I., Raposo, G., Savina, A., Moita, C.F., Schauer, K., Hume, A.N., Freitas, R.P., Goud, B., Benaroch, P., Hacohen, N., Fukuda, M., Desnos, C., Seabra, M.C., Darchen, F., Amigorena, S., Moita, L.F., Thery, C., 2010. Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat. Cell Biol. 12 (19-30), 11–13.
Patel, V., Carrion, K., Hollands, A., Hinton, A., Gallegos, T., Dyo, J., Sasik, R., Leire, E., Hardiman, G., Mohamed, S.A., Nigam, S., King, C.C., Nizet, V., Nigam, V., 2015. The stretch responsive microRNA miR-148a-3p is a novel repressor of IKBKB, NF-κB signaling, and inflammatory gene expression in human aortic valve cells. FASEB J. 29, 1859–1868.
Saha, B., Momen-Heravi, F., Kodys, K., Szabo, G., 2016. MicroRNA cargo of extracellular vesicles from alcohol-exposed monocytes signals naive monocytes to differentiate into M2 macrophages. J. Biol. Chem. 291, 149–159.
Seo, W., Eun, H.S., Kim, S.Y., Yi, H.S., Lee, Y.S., Park, S.H., Jang, M.J., Jo, E., Kim, S.C.,Han, Y.M., Park, K.G., Jeong, W.I., 2016. Exosome-mediated activation of toll-like receptor 3 in stellate cells stimulates interleukin-17 production by γδ T cells in liver fibrosis. Hepatology 64, 616–631.
Shao, M., Xu, Q., Wu, Z., Chen, Y., Shu, Y., Cao, X., Chen, M., Zhang, B., Zhou, Y., Yao, R., Shi, Y., Bu, H., 2020. Exosomes derived from human umbilical cord mesenchymal stem cells ameliorate IL-6-induced acute liver injury through miR-455-3p. Stem Cell Res. Ther. 11, 37.
Smith, V.L., Cheng, Y., Bryant, B.R., Schorey, J.S., 2017. Exosomes function in antigen presentation during an in vivo Mycobacterium tuberculosis infection. Sci. Rep. 7, 43578.
Stravitz, R.T., Lee, W.M., 2019. Acute liver failure. Lancet 394, 869–881.
Su, W., Sun, J., Shimizu, K., Kadota, K., 2019. TCC-GUI: a Shiny-based application for differential expression analysis of RNA-Seq count data. BMC Res. Notes 12, 133. Tagawa, Y., Matthys, P., Heremans, H., Dillen, C., Zaman, Z., Iwakura, Y., Billiau, A.,2000. Bimodal role of endogenous interleukin-6 in concanavalin A-induced hepatitis in mice. J. Leukoc. Biol. 67, 90–96.
Takahashi, K., Yan, I.K., Wood, J., Haga, H., Patel, T., 2014. Involvement of extracellular vesicle long noncoding RNA (linc-VLDLR) in tumor cell responses to chemotherapy. Mol. Cancer Res. 12, 1377–1387.
Tamura, R., Uemoto, S., Tabata, Y., 2016. Immunosuppressive effect of mesenchymal stem cell-derived exosomes on a concanavalin A-induced liver injury model. Inflamm. Regen. 36, 26.
Taylor, D.D., Gercel-Taylor, C., 2013. The origin, function, and diagnostic potential of RNA within extracellular vesicles present in human biological fluids. Front. Genet. 4, 142.
Tominaga, N., Kosaka, N., Ono, M., Katsuda, T., Yoshioka, Y., Tamura, K., Lötvall, J., Nakagama, H., Ochiya, T., 2015. Brain metastatic cancer cells release microRNA- 181c-containing extracellular vesicles capable of destructing blood-brain barrier. Nat. Commun. 6, 6716.
Ugai, H., Yamasaki, T., Hirose, M., Inabe, K., Kujime, Y., Terashima, M., Liu, B., Tang, H.,Zhao, M., Murata, T., Kimura, M., Pan, J., Obata, Y., Hamada, H., Yokoyama, K.K., 2005. Purification of infectious adenovirus in two hours by ultracentrifugation and tangential flow filtration. Biochem. Biophys. Res. Commun. 331, 1053–1060.
Vergadi, E., Ieronymaki, E., Lyroni, K., Vaporidi, K., Tsatsanis, C., 2017. Akt signaling pathway in macrophage activation and M1/M2 polarization. J. Immunol. 198, 1006–1014.
Wheeler, M.D., Yamashina, S., Froh, M., Rusyn, I., Thurman, R.G., 2001. Adenoviral gene delivery can inactivate Kupffer cells: role of oxidants in NF-kappaB activation and cytokine production. J. Leukoc. Biol. 69, 622–630.
Willekens, F.L., Werre, J.M., Kruijt, J.K., Roerdinkholder-Stoelwinder, B., Groenen-Döpp, Y.A., van den Bos, A.G., Bosman, G.J., van Berkel, T.J., 2005. Liver Kupffer cells rapidly remove red blood cell-derived vesicles from the circulation by scavenger receptors. Blood 105, 2141–2145.
Xue, J., Chen, F., Wang, J., Wu, S., Zheng, M., Zhu, H., Liu, Y., He, J., Chen, Z., 2015.Emodin protects against concanavalin A-induced hepatitis in mice through inhibiting activation of the p38 MAPK-NF-κB signaling pathway. Cell Physiol. Biochem. 35, 1557–1570.
Yang, J., Wang, B., Zhang, C.F., Xu, X.H., Zhang, M., 2019. A C21-steroidal glycoside from cynanchum atratum attenuates concanavalin A-induced liver injury in mice. Molecules 24, 1087.
Yang, M.Q., Du, Q., Goswami, J., Varley, P.R., Chen, B., Wang, R.H., Morelli, A.E., Stolz, D.B., Billiar, T.R., Li, J., Geller, D.A., 2018. Interferon regulatory factor 1-Rab27a regulated extracellular vesicles promote liver ischemia/reperfusion injury.Hepatology 67, 1056–1070.
Zhao, Z., Zhong, L., Li, P., He, K., Qiu, C., Zhao, L., Gong, J., 2020. Cholesterol impairs hepatocyte lysosomal function causing M1 polarization of macrophages via exosomal miR-122-5p. Exp. Cell Res. 387, 111738.
Zheng, W., Wang, Q., Lu, X., Shi, Q., Zou, J., Tao, Y., Wang, P., 2016. Protective effects of Dracocephalum heterophyllum in conA-induced acute hepatitis. Mediators Inflamm. 2016, 2684321.
Zheng, Y., He, R., Wang, P., Shi, Y., Zhao, L., Liang, J., 2019. Exosomes from LPS-sti- mulated macrophages induce neuroprotection and functional improvement after is- chemic stroke by modulating microglial polarization. Biomater. Sci. 7, 2037–2049.
Zhuang, Y., Li, Y., Li, X., Xie, Q., Wu, M., 2016. Atg7 knockdown augments concanavalin A-induced acute hepatitis through an ROS-mediated p38/MAPK pathway. PLoS One 11, e0149754.