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Acknowledgements
The authors thank Ikuko Okuda, our clerical staff, for office work and data management.
Author contributions
S.M.: Conceptualization, Methodology, Investigation, Project administration, Writing—original draft. K.N.: Data
Curation, Formal analysis, Investigation, Visualization, Writing—original draft. K.M.: Data Curation, Investigation, Writing—review and editing. H.O.: Data Curation, Investigation, Writing—review and editing. Y.F:
Resources, Writing—review and editing. K.K.: Writing—review and editing.
Funding
This study was supported by a research grant from the Japan Society for the Promotion of Science KAKENHI
(Grant Nos.: 16H01880, 16K13072, 18H00994, 18H03388), AMED under Grant Number 20gk0110043h0002
and RIKEN Healthcare and Medical Data Platform Project.
Competing interests The authors declare no competing interests.
Additional information
Supplementary Information The online version contains supplementary material available at https://doi.org/
10.1038/s41598-022-12330-1.
Correspondence and requests for materials should be addressed to S.M.
Reprints and permissions information is available at www.nature.com/reprints.
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and
institutional affiliations.
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