[1]
[2]
[3]
Piao J, Zabierowski S, Dubose BN, Hill EJ, Navare M,
Claros N, Rosen S, Ramnarine K, Horn C, Fredrickson C,
Wong K, Safford B, Kriks S, El Maarouf A, Rutishauser U,
Henchcliffe C, Wang Y, Riviere I, Mann S, Bermudez V,
Irion S, Studer L, Tomishima M, Tabar V (2021) Preclinical
efficacy and safety of a human embryonic stem cell-derived
midbrain dopamine progenitor product, MSK-DA01. Cell
Stem Cell 28, 217-229.e7.
Schweitzer JS, Song B, Herrington TM, Park TY, Lee N,
Ko S, Jeon J, Cha Y, Kim K, Li Q, Henchcliffe C, Kaplitt
M, Neff C, Rapalino O, Seo H, Lee IH, Kim J, Kim T,
Petsko GA, Ritz J, Cohen BM, Kong SW, Leblanc P, Carter
BS, Kim KS (2020) Personalized iPSC-derived dopamine
progenitor cells for Parkinson’s disease. N Engl J Med 382,
1926-1932.
Doi D, Magotani H, Kikuchi T, Ikeda M, Hiramatsu S,
Yoshida K, Amano N, Nomura M, Umekage M, Morizane
A, Takahashi J (2020) Pre-clinical study of induced
[13]
[14]
[15]
S171
pluripotent stem cell-derived dopaminergic progenitor cells
for Parkinson’s disease. Nat Commun 11, 3369.
Takahashi J (2020) iPS cell-based therapy for Parkinson’s
disease: A Kyoto trial. Regen Ther 13, 18-22.
Freed CR, Greene PE, Breeze RE, Tsai WY, DuMouchel
W, Kao R, Dillon S, Winfield H, Culver S, Trojanowski
JQ (2001) Transplantation of embryonic dopamine neurons for severe Parkinson’s disease. N Engl J Med 344,
710-719.
Louveau A, Smirnov I, Keyes TJ, Eccles JD, Rouhani SJ,
Peske JD, Derecki NC, Castle D, Mandell JW, Lee KS, Harris TH, Kipnis J (2015) Structural and functional features
of central nervous system lymphatic vessels. Nature 523,
337-341.
Krystkowiak P, Gaura V, Labalette M, Rialland A, Remy
P, Peschanski M, Bachoud-L´evi A-C (2007) Alloimmunisation to donor antigens and immune rejection following
foetal neural grafts to the brain in patients with Huntington’s
disease. PLoS One 2, e166.
Morizane A, Doi D, Kikuchi T, Okita K, Hotta A, Kawasaki
T, Hayashi T, Onoe H, Shiina T, Yamanaka S, Takahashi
J (2013) Direct comparison of autologous and allogeneic
transplantation of iPSC-derived neural cells in the brain of
a nonhuman primate. Stem Cell Reports 1, 283-292.
Mandai M, Watanabe A, Kurimoto Y, Hirami Y, Morinaga
C, Daimon T, Fujihara M, Akimaru H, Sakai N, Shibata Y,
Terada M, Nomiya Y, Tanishima S, Nakamura M, Kamao H,
Sugita S, Onishi A, Ito T, Fujita K, Kawamata S, Go MJ, Shinohara C, Hata K-I, Sawada M, Yamamoto M, Ohta S, Ohara
Y, Yoshida K, Kuwahara J, Kitano Y, Amano N, Umekage M, Kitaoka F, Tanaka A, Okada C, Takasu N, Ogawa
S, Yamanaka S, Takahashi M (2017) Autologous induced
stem-cell-derived retinal cells for macular degeneration. N
Engl J Med 376, 1038-1046.
Shiba Y, Gomibuchi T, Seto T, Wada Y, Ichimura H, Tanaka
Y, Ogasawara T, Okada K, Shiba N, Sakamoto K, Ido D,
Shiina T, Ohkura M, Nakai J, Uno N, Kazuki Y, Oshimura
M, Minami I, Ikeda U (2016) Allogeneic transplantation of
iPS cell-derived cardiomyocytes regenerates primate hearts.
Nature 538, 388-391.
Umekage M, Sato Y, Takasu N (2019) Overview: An iPS
cell stock at CiRA. Inflamm Regen 39, 17.
Okita K, Matsumura Y, Sato Y, Okada A, Morizane A,
Okamoto S, Hong H, Nakagawa M, Tanabe K, Tezuka KI, Shibata T, Kunisada T, Takahashi M, Takahashi J, Saji
H, Yamanaka S (2011) A more efficient method to generate integration-free human iPS cells. Nat Methods 8, 409412.
Morizane A, Kikuchi T, Hayashi T, Mizuma H, Takara S,
Doi H, Mawatari A, Glasser MF, Shiina T, Ishigaki H, Itoh
Y, Okita K, Yamasaki E, Doi D, Onoe H, Ogasawara K,
Yamanaka S, Takahashi J (2017) MHC matching improves
engraftment of iPSC-derived neurons in non-human primates. Nat Commun 8, 385.
Aron Badin R, Bugi A, Williams S, Vadori M, Michael
M, Jan C, Nassi A, Lecourtois S, Blancher A, Cozzi E,
Hantraye P, Perrier AL (2019) MHC matching fails to
prevent long-term rejection of iPSC-derived neurons in nonhuman primates. Nat Commun 10, 4357.
Ichise H, Nagano S, Maeda T, Miyazaki M, Miyazaki Y,
Kojima H, Yawata N, Yawata M, Tanaka H, Saji H, Masuda
K, Kawamoto H (2017) NK cell alloreactivity against KIRligand-mismatched HLA-haploidentical tissue derived from
HLA haplotype-homozygous iPSCs. Stem Cell Reports 9,
853-867.
A Self-archived copy in
Kyoto University Research Information Repository
https://repository.kulib.kyoto-u.ac.jp
S172
[16]
[17]
[18]
[19]
[20]
[21]
[22]
A. Morizane and J. Takahashi / Evading the Immune System
Gornalusse GG, Hirata RK, Funk SE, Riolobos L, Lopes
VS, Manske G, Prunkard D, Colunga AG, Hanafi LA,
Clegg DO, Turtle C, Russell DW (2017) HLA-E-expressing
pluripotent stem cells escape allogeneic responses and lysis
by NK cells. Nat Biotechnol 35, 765-772.
Han X, Wang M, Duan S, Franco PJ, Kenty JH, Hedrick P,
Xia Y, Allen A, Ferreira LMR, Strominger JL, Melton DA,
Meissner TB, Cowan CA (2019) Generation of hypoimmunogenic human pluripotent stem cells. Proc Natl Acad
Sci U S A 116, 10441-10446.
Xu H, Wang B, Ono M, Kagita A, Fujii K, Sasakawa N, Ueda
T, Gee P, Nishikawa M, Nomura M, Kitaoka F, Takahashi
T, Okita K, Yoshida Y, Kaneko S, Hotta A (2019) Targeted
disruption of HLA genes via CRISPR-Cas9 generates iPSCs
with enhanced immune compatibility. Cell Stem Cell 24,
566-578.e7.
Elmer BM, McAllister AK (2012) Major histocompatibility
complex class I proteins in brain development and plasticity.
Trends Neurosci 35, 660-670.
Rong Z, Wang M, Hu Z, Stradner M, Zhu S, Kong H,
Yi H, Goldrath A, Yang YG, Xu Y, Fu X (2014) An
effective approach to prevent immune rejection of human
ESC-derived allografts. Cell Stem Cell 14, 121-130.
Piccini P, Pavese N, Hagell P, Reimer J, Bj¨orklund A, Oertel WH, Quinn NP, Brooks DJ, Lindvall O (2005) Factors
affecting the clinical outcome after neural transplantation in
Parkinson’s disease. Brain 128, 2977-2986.
Wickstrøm T, Clarke A, Gausemel I, Horn E, Jørgensen K,
Khan I, Mantzilas D, Rajanayagam T, in ‘t Veld D-J, Trigg W
(2014) The development of an automated and GMP compliant FASTlab™ Synthesis of [(18) F]GE-180; a radiotracer
for imaging translocator protein (TSPO). J Labelled Comp
Radiopharm 57, 42-48.
[23]
[24]
[25]
[26]
[27]
[28]
Jain P, Chaney AM, Carlson ML, Jackson IM, Rao A, James
ML (2020) Neuroinflammation PET imaging: Current opinion and future directions. J Nucl Med 61, 1107-1112.
Sugita S, Makabe K, Fujii S, Iwasaki Y, Kamao H, Shiina
T, Ogasawara K, Takahashi M (2017) Detection of retinal
pigment epithelium-specific antibody in iPSC-derived retinal pigment epithelium transplantation models. Stem Cell
Reports 9, 1501-1515.
Sugita S, Iwasaki Y, Makabe K, Kamao H, Mandai M, Shiina
T, Ogasawara K, Hirami Y, Kurimoto Y, Takahashi M (2016)
Successful transplantation of retinal pigment epithelial cells
from MHC homozygote iPSCs in MHC-matched models.
Stem Cell Reports 7, 635-648.
Sugita S, Mandai M, Hirami Y, Takagi S, Maeda T, Fujihara
M, Matsuzaki M, Yamamoto M, Iseki K, Hayashi N, Hono
A, Fujino S, Koide N, Sakai N, Shibata Y, Terada M, Nishida
M, Dohi H, Nomura M, Amano N, Sakaguchi H, Hara C,
Maruyama K, Daimon T, Igeta M, Oda T, Shirono U, Tozaki
M, Totani K, Sugiyama S, Nishida K, Kurimoto Y, Takahashi M (2020) HLA-matched allogeneic iPS cells-derived
RPE transplantation for macular degeneration. J Clin Med
9, 2217.
Snyder TM, Khush KK, Valantine HA, Quake SR (2011)
Universal noninvasive detection of solid organ transplant
rejection. Proc Natl Acad Sci U S A 108, 6229-6234.
Dengu F (2020) Next-generation sequencing methods to
detect donor-derived cell-free DNA after transplantation.
Transplant Rev (Orlando) 34, 100542.
...