1. Park HS, Kim JS, Choi BG, et al. Sonochemical hybridization of carbon nanotubes with gold nanoparticles for the production of flexible transparent conducing films. Carbon. 2010;48(5):1325–1330. doi:10.1016/j.carbon.2009.11.054
2. He H, Pham-Huy LA, Dramou P, Xiao D, Zuo P, Pham-Huy C. Carbon nanotubes: applications in pharmacy and medicine. Biomed Res Int. 2013;2013:578290. doi:10.1155/2013/578290
3. Silva RM, Doudrick K, Franzi LM, et al. Instillation versus inhalation of multiwalled carbon nanotubes: exposure-related health effects, clearance, and the role of particle characteristics. ACS Nano. 2014;8 (9):8911–8931. doi:10.1021/nn503887r
4. Muller J, Huaux F, Moreau N, et al. Respiratory toxicity of multi-wall carbon nanotubes. Toxicol Appl Pharmacol. 2005;207(3):221–231. doi:10.1016/j.taap.2005.02.021
5. Takagi A, Hirose A, Nishimura T, et al. Induction of mesothelioma in p53+/− mouse by intraperitoneal application of multi-wall carbon nanotube. J Toxicol Sci. 2008;33(1):105–116. doi:10.2131/jts.33.105
6. Yamashita K, Yoshioka Y, Higashisaka K, et al. Carbon nanotubes elicit DNA damage and inflammatory response relative to their size and shape. Inflammation. 2010;33(4):276–280. doi:10.1007/s10753-010-9182-7
7. Nagai H, Okazaki Y, Hwu S, Misawa N, Yamashita Y, Akatsuka S. Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis. Proc Natl Acad Sci USA. 2011;108(49):E1330–E1338. doi:10.1073/pnas.1110013108
8. Donaldson K, Murphy FA, Duffin R, Poland CA. Asbestos, carbon nano- tubes and the pleural mesothelium : a review of the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma. Part Fibre Toxicol. 2010;7:5. doi:10.1186/1743-8977-7-5
9. Matsumoto M, Serizawa H, Sunaga M, et al. No toxicological effects on acute and repeated oral gavage doses of single-wall or multi-wall carbon nanotube in rats. J Toxicol Sci. 2012;37(3):463–474.
10. El-Gazzar AM, Abdelgied M, Alexander DB, et al. Comparative pulmonary toxicity of a DWCNT and MWCNT-7 in rats. Arch Toxicol. 2019;93(1):49–59. doi:10.1007/s00204-018-2336-3
11. Mercer RR, Scabilloni JF, Hubbs AF, et al. Extrapulmonary transport of MWCNT following inhalation exposure. Part Fibre Toxico. 2013;10:38. doi:10.1186/1743-8977-10-56
12. Thompson LC, Holland NA, Snyder RJ, et al. Pulmonary instillation of MWCNT increases lung permeability, decreases gp130 expression in the lungs, and initiates cardiovascular IL-6 transsignaling. Am J Physiol Lung Cell Mol Physiol. 2016;310(2):L142–L154. doi:10.1152/ajplung.00384.2014
13. Kasai T, Umeda Y, Ohnishi M, Mine T, Kondo H, Takeuchi T. Lung carcinogenicity of inhaled multi- walled carbon nanotube in rats. Part Fibre Toxicol. 2016;13(1):53. doi:10.1186/s12989-016-0164-2
14. Hara K, Aoki K, Usui Y, et al. Evaluation of CNT toxicity by comparison to tattoo ink. Mater Today. 2011;14(9):434–440. doi:10.1016/S1369-7021(11)70188-2
15. Eletskii AV. Carbon nanotube-based electron field emitters. Phys Usp. 2010;53:863–889. doi:10.3367/UFNe.0180.201009a.0897
16. Rosen Y, Elman NM. Carbon nanotubes in drug delivery: focus on infectious diseases. Expert Opin Drug Deliv. 2009;6(5):517–530. doi:10.1517/17425240902865579
17. Usui Y, Aoki K, Narita N, et al. Carbon nanotubes with high bone- tissue compatibility and bone-formation acceleration effects. Small. 2008;4(2):240–242. doi:10.1002/smll.200700670
18. Shimizu M, Kobayashi Y, Mizoguchi T, et al. Carbon nanotubes induce bone calcification by bidirectional interaction with osteoblasts. Adv Mater. 2012;24(16):2176–2185. doi:10.1002/adma.201103832
19. Tanaka M, Sato Y, Zhang M, et al. In vitro and in vivo evaluation of a three- dimensional porous multi-walled carbon nanotube scaffold for bone regen- eration. Nanomaterials (Basel). 2017;7(2):46. doi:10.3390/nano7120458
20. Tanaka M, Sato Y, Haniu H, et al. A three-dimensional block struc- ture consisting exclusively of carbon nanotubes serving as bone regeneration scaffold and as bone defect filler. PLoS One. 2017;12 (2):e0172601. doi:10.1371/journal.pone.0172601
21. Jain S, Thakare VS, Das M, et al. Toxicity of multiwalled carbon nanotubes with end defects critically depends on their functionaliza- tion density. Chem Res Toxicol. 2011;24(11):2028–2039. doi:10. 1021/tx2003728
22. Pauluhn J. Subchronic 13-week inhalation exposure of rats to multi- walled carbon nanotubes: toxic effects are determined by density of agglomerate structures, not fibrillar structures. Toxicol Sci. 2010;113 (1):226–242. doi:10.1093/toxsci/kfp247
23. U.S. Department of Health, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health. Current intelligence bulletin 65, occupational exposure to carbon nanotubes and nanofibers. DHHS (NIOSH) Publication No. 2013-145. April 2013. Available from: https://www.cdc.gov/niosh/docs/2013-145/pdfs/2013-145.pdf. Accessed February 11, 2019.
24. Hosseinpour M, Azimirad V, Alimohammadi M, Shahabi P, Sadighi M. The cardiac effects of carbon nanotubes in rat. Bioimpacts. 2016;6 (2):79–84. doi:10.15171/bi.2016.11
25. Rittinghausen S, Hackbarth A, Creutzenberg O, et al. The carcino- genic effect of various multi-walled carbon nanotubes (MWCNTs) after intraperitoneal injection in rats. Part Fibre Toxicol. 2014;11:59. doi:10.1186/s12989-014-0059-z
26. Mercer RR, Scabilloni JF, Hubbs AF, et al. Distribution and fibrotic response following inhalation exposure to multi-walled carbon nano- tubes. Part Fibre Toxicol. 2013;10:33. doi:10.1186/1743-8977-10-56
27. Yamaguchi A, Fujitani T, Ohyama K, et al. Effects of sustained stimulation with multi-wall carbon nanotubes on immune and inflam- matory responses in mice. J Toxicol Sci. 2012;37(1):177–189.
28. Muller J, Delos M, Panin N, Rabolli V, Huaux F, Lison D. Absence of carcinogenic response to multiwall carbon nanotubes in a 2-year bioassay in the peritoneal cavity of the rat. Toxicol Sci. 2009;110 (2):442–448. doi:10.1093/toxsci/kfp100
29. Urano K, Suzuki S, Machida K, et al. Examination of percutaneous application in a 26-week carcinogenicity test in CB6F1-TG rasH2 mice. J Toxicol Sci. 2007;32(4):367–375. doi:10.2131/jts.32.367
30. Kuroda C, Ueda K, Haniu H, et al. Different aggregation and shape characteristics of carbon materials affect biological responses in RAW264 cells. Int J Nanomedicine. 2018;13:6079–6088. doi:10.2147/IJN.S177627
31. Takaya M, Serita F, Yamazaki K, et al. Characteristics of multiwall carbon nanotubes for an intratracheal instillation study with rats. Ind Health. 2010;48:452–459. doi:10.2486/indhealth.MS1128
32. Paranjpe MG, Elbekaei RH, Shah SA, Hickman M, Wenk ML, Zahalka EA. Historical control data of spontaneous tumors in trans- genic CByB6F1-Tg(HRAS)2Jic (Tg.rasH2) mice. Int J Toxicol. 2013;32(1):48–57. doi:10.1177/1091581812471565
33. Suguro M, Numano T, Kawabe M, et al. Tumor induction by 26- week dermal application of 1, 2-Dichloroethane in CB6F1-Tg rasH2 mice. Toxicol Pathol. 2017;45(3):427–434. doi:10.1177/ 0192623317701003
34. Morton D, Alden CL, Roth AJ, Usui T. The Tg rasH2 mouse in cancer hazard identification. Toxicol Pathol. 2002;30(1):139–146. doi:10.1080/01926230252824851
35. Macdonald J, French J, Gerson RJ, et al. The utility of genetically modified mouse assays for identifying human carcinogens : a basic understanding and path forward. Toxicol Sci. 2004;77(2):188–194. doi:10.1093/toxsci/kfh037
36. Long GG, Morton D, Peters T, Short B, Skydgaard M. Alternative mouse models for carcinogenicity assessment : industry use and issues with pathology interpretation. Toxicol Pathol. 2010;38(1):43– 50. doi:10.1177/0192623309354107
37. Nambiar PR, Morton D. The rasH2 mouse model for assessing carcinogenic potential of pharmaceuticals. Toxicol Pathol. 2013;41 (8):1058–1067. doi:10.1177/0192623313477257
38. Tamaoki N. The rasH2 transgenic mouse: nature of the model and mechanistic studies on tumorigenesis. Toxicol Pathol. 2001;29 (Suppl):81–89. doi:10.1080/019262301753385933
39. Tsuji S, Kuwahara Y, Takagi H, Sugiura M. Gene expression analysis in the lung of the rasH2 transgenic mouse at week 4 prior to induc- tion of malignant tumor formation by urethane and N-methylolacry- lamide. J Toxicol Sci. 2015;40(6):685–700. doi:10.2131/jts.40.887
40. ISO 10993-1: 2018. Biological Evaluation of Medical Devices - Part 1: Evaluation and Testing within a Risk Management Process.
41. ISO 10993-3:2014. Biological Evaluation of Medical Devices - Part 3: Tests for Genotoxicity, Carcinogenicity and Reproductive Toxicity.
42. Urano K, Suzuki S, Machida K, Sawa N, Eguchi N. Use of IC tags in short-term carcinogenicity study on CB6F1 TGrasH2 mice. J Toxicol Sci. 2006;31:407–418. doi:10.2131/jts.31.407
43. Takanashi S, Hara K, Aoki K, et al. Carcinogenicity evaluation for the application of carbon nanotubes as biomaterials in rasH2 mice. Sci Rep. 2012;2:498. doi:10.1038/srep00386
44. Castranova V, Schulte PA, Zumwalde RD. Occupational nanosafety considerations for carbon nanotubes and carbon nanofibers. Acc Chem Res. 2013;46(3):642–649. doi:10.1021/ar300004a
45. ISO/TS 13278: 2017. Nanotechnologies - Determination of Elemental Impurities in Samples of Carbon Nanotubes Using Inductively Coupled Plasma Mass Spectrometry.
46. ISO/TS 11888: 2017. Nanotechnologies - Characterization of Multiwall Carbon Nanotubes - Mesoscopic Shape Factors.
47. ISO/TS 12805: 2011. Nanotechnologies - Materials Specifications - Guidance on Specifying Nano-Objects.
48. Badie BH, Rezaee R, Valokala GM, et al. Cardiotoxicity of nano- particles. Life Sci. 2016;165:91–99. doi:10.1016/j.lfs.2016.09.017
49. Wu T, Tang M. Review of the effects of manufactured nanoparticles on mammalian target organs. J Appl Toxicol. 2018;38(1):25–40. doi:10.1002/jat.v38.1
50. Qu G, Bai Y, Zhang Y, Jia Q, Zhang W, Yan B. The effect of multiwalled carbon nanotube agglomeration on their accumulation in and damage to organs in mice. Carbon. 2009;47(8):2060–2069. doi:10.1016/j.carbon.2009.03.056
51. Zhang T, Tang M, Zhang S, et al. Systemic and immunotoxicity of pristine and PEGylated multi-walled carbon nanotubes in an intrave- nous 28 days repeated dose toxicity study. Int J Nanomedicine. 2017;12:1539–1554. doi:10.2147/IJN.S123345
52. Ji Z, Zhang D, Li L, et al. The hepatotoxicity of multi-walled carbon nanotubes in mice. Nanotechnology. 2009;20:44. doi:10.1088/0957- 4484/20/44/445101
53. Toyokuni S. Genotoxicity and carcinogenicity risk of carbon nano- tubes. Adv Drug Deliv Rev. 2013;65:2098–2110. doi:10.1016/j. addr.2013.05.011
54. Firme CP, Bandaru PR. Toxicity issues in the application of carbon nanotubes to biological systems. Nanomedicine (Basel). 2010;6 (2):245–256. doi:10.1016/j.nano.2009.07.003
55. Iancu C, Mocan L. Advances in cancer therapy through the use of carbon nanotube-mediated targeted hyperthermia. Int J Nanomedicine. 2011;6:1675–1684. doi:10.2147/IJN.S25646
56. Sakamoto Y, Nakae D, Fukumori N, et al. Induction of mesothe- lioma by a single intrascrotal administration of multi-wall carbon nanotube in intact male Fischer 344 rats. J Toxicol Sci. 2009;34 (1):65–76.
57. Kavosi A, Hosseini S, Noei G, Madani S, Khalighfard S. The toxicity and therapeutic effects of single-and multi-wall carbon nanotubes on mice breast cancer. Sci Rep. 2018;8(1):8375. doi:10.1038/s41598- 018-26790-x
58. Crouzier D, Follot S, Gentilhomme E, et al. Carbon nanotubes induce inflammation but decrease the production of reactive oxygen species in lung. Toxicology. 2010;272(1–3):39–45. doi:10.1016/j.tox.2010.04.001
59. Nygaard UC, Hansen JS, Samuelsen M, Alberg T, Marioara CD, Løvik M. Single-walled and multi-walled carbon nanotubes promote allergic immune responses in mice. Toxicol Sci. 2009;109(1):113–123. doi:10.1093/toxsci/kfp057
60. Sato Y, Yokoyama A, Shibata K, et al. Influence of length on cytotoxi- city of multi-walled carbon nanotubes against human acute monocytic leukemia cell line THP-1 in vitro and subcutaneous tissue of rats in vivo. Mol Biosyst. 2005;1(2):176–182. doi:10.1039/b502429c
61. Yoshizawa K, Yuki M, Kinoshita Y, et al. N-methyl-N-nitrosourea- induced schwannomas in male Sprague-Dawley rats with a literature review of inducible and spontaneous lesions. Exp Toxicol Pathol. 2016;68(7):371–379. doi:10.1016/j.etp.2016.05.005
62. Teixeira-Guedes CI, Faustino-Rocha AI, Talhada D, et al. A liver schwannoma observed in a female Sprague-Dawley rat treated with MNU. Exp Toxicol Pathol. 2014;66(2–3):125–128. doi:10.1016/j. etp.2013.11.003
論文の公開元へ
