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大学・研究所にある論文を検索できる 「Usefulness of 2-Dimensional Speckle Tracking Echocardiography and Diffusion Tensor Imaging for the Detection of Myocardial Fibrosis in a Rat Model of Right Ventricular Pressure Overload (Original)」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。
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Usefulness of 2-Dimensional Speckle Tracking Echocardiography and Diffusion Tensor Imaging for the Detection of Myocardial Fibrosis in a Rat Model of Right Ventricular Pressure Overload (Original)

河内, 文江 畑, 純一 河内, 貞貴 岡野, ジェイムス, 洋尚 井田, 博幸 浦島, 崇 平野, 大志 東京慈恵会医科大学

2020.12.10

概要

Background :
　Two-dimensional speckle tracking echocardiography (2DSTE) has attracted a great deal of attention as an index that more acutely reflects a decrease in ventricular contractility than ejection fraction. Diffusion tensor imaging (DTI) is useful in the diagnosis of myocardial infarc-tion, mainly in the left ventricle. This study aimed to investigate whether 2DSTE and DTI could be used to predict right ventricular (RV) myocardial fibrosis.

Methods :
　Five-week-old Sprague Dawley rats were randomly divided into 2 groups : a pulmo-nary artery banding group and a sham group (n = 10 for both). The rats were killed after echocardiog-raphy and cardiac catheterization at 4 weeks postoperatively and underwent DTI and histological analysis.

Results :
　The pulmonary artery banding group showed significant RV fibrosis compared to the sham group, and there was a significant negative correlation between the RV longitudinal strain score and fibrosis (Spearman’s ρ = −0.42,  P < 0.01). Moreover, λ1 showed a significant negative correla-tion with RV myocardial fibrosis based on the diffusion eigenvalues (λ1, 2, 3) and fractional anisotropy (ρ = −0.79,  P = 0.036). In addition, the number of myocardial fibers depicted on fiber tractography decreased as fibrosis increased in all sagittal, coronal, and lateral sections.

Conclusions :
　This study demonstrated the potential usefulness of 2DSTE and DTI as noninva-sive options for the early diagnosis of RV fibrosis.

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