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大学・研究所にある論文を検索できる 「Impact of Preoperative Occult-Bacterial Translocation on Surgical Site Infection in Patients Undergoing Pancreatoduodenectomy」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。
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Impact of Preoperative Occult-Bacterial Translocation on Surgical Site Infection in Patients Undergoing Pancreatoduodenectomy

Suenaga, Masaya Yokoyama, Yukihiro Fujii, Tsutomu Yamada, Suguru Yamaguchi, Junpei Hayashi, Masamichi Asahara, Takashi Nagino, Masato Kodera, Yasuhiro 名古屋大学

2021.03

概要

Background:
Occult-bacterial translocation (O-BT) has been reported as the condition in which microorganisms are detected in blood or lymph nodes by a highly sensitive method. However, the clinical impact of preoperative O-BT on postoperative complication is unclear. Study

design:
A prospective observational study with patients undergoing pancreatoduodenectomy for periampullary diseases was conducted. Blood samples were collected immediately after induction of anesthesia. The status of O-BT was investigated using bacterium-specific ribosomal RNA-targeted reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR). The impact of O-BT on surgical site infection (SSI) was analyzed.

Results:
A total of 155 patients were included. The positive rate in preoperative blood samples detected by RT-qPCR was significantly higher than that obtained by the culture method (32 of 155 vs 4 of 155, p < 0.001). Preoperative blood samples were contaminated with 1.0 to 19.2 bacterial cells/mL in positive patients, and 30 of the 41 detected microorganisms were obligate anaerobes. No differences in preoperative factors were observed between patients with positive and negative RT-qPCR results. The incidence of any SSI was significantly higher in patients with contaminated preoperative blood (≥1.2 bacterial cells/mL) than in other patients (14 of 27 vs 35 of 128, p = 0.013). Multivariable analysis indicated that contaminated preoperative blood was identified as one of the independent risk factors for SSI (odds ratio 2.71, 95% CI 1.04 to 7.24, p = 0.041).

Conclusions:
O-BT, predominantly with obligate anaerobes, was commonly observed in preoperative blood samples. In addition to the previously known risk factors, O-BT may be one of the risk factors for SSI after pancreatoduodenectomy.

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参考文献

1. Kimura W, Miyata H, Gotoh M, et al. A pancreaticoduodenectomy risk model derived from 8575 cases from a national single-race population (Japanese) using a web-based data entry system: the 30-day and in-hospital mortality rates for pancreaticoduodenectomy. Ann Surg 2014;259(4): 773-780.

2. Fujii T, Sugimoto H, Yamada S, et al. Modified Blumgart anastomosis for pancreaticojejunostomy: technical improvement in matched historical control study. J Gastrointest Surg 2014;18(6): 1108-1115.

3. Mizuno T, Yokoyama Y, Nishio H, et al. Intraoperative bacterial translocation detected by bacterium-specific ribosomal rna-targeted reverse-transcriptase polymerase chain reaction for the mesenteric lymph node strongly predicts postoperative infectious complications after major hepatectomy for biliary malignancies. Ann Surg 2010;252(6): 1013-1019.

4. Nishigaki E, Abe T, Yokoyama Y, et al. The detection of intraoperative bacterial translocation in the mesenteric lymph nodes is useful in predicting patients at high risk for postoperative infectious complications after esophagectomy. Ann Surg 2014;259(3): 477-484.

5. Yokoyama Y, Nishigaki E, Abe T, et al. Randomized clinical trial of the effect of perioperative synbiotics versus no synbiotics on bacterial translocation after oesophagectomy. Br J Surg 2014;101(3): 189-199.

6. Yokoyama Y, Miyake T, Kokuryo T, et al. Effect of Perioperative Synbiotic Treatment on Bacterial Translocation and Postoperative Infectious Complications after Pancreatoduodenectomy. Dig Surg 2016;33(3): 220-229.

7. Suenaga M, Yokoyama Y, Fujii T, et al. Impact of qualitative and quantitative biliary contamination status on the incidence of postoperative infection complications in patients undergoing pancreatoduodenectomy. Ann Surg Oncol 2020, in press.

8. Matsuda K, Tsuji H, Asahara T, et al. Sensitive quantitative detection of commensal bacteria by rRNA-targeted reverse transcription-PCR. Appl Environ Microbiol 2007;73(1): 32-39.

9. Matsuda K, Tsuji H, Asahara T, et al. Establishment of an analytical system for the human fecal microbiota, based on reverse transcription-quantitative PCR targeting of multicopy rRNA molecules. Appl Environ Microbiol 2009;75(7): 1961-1969.

10. Yokoyama Y, Fukaya M, Mizuno T, et al. Clinical importance of "occult-bacterial translocation" in patients undergoing highly invasive gastrointestinal surgery: A review. Surg Today 2020.

11. Ikeda M, Okusaka T, Ito Y, et al. A phase I trial of S-1 with concurrent radiotherapy for locally advanced pancreatic cancer. Br J Cancer 2007;96(11): 1650-1655.

12. Fujii T, Yamada S, Suenaga M, et al. Preoperative internal biliary drainage increases the risk of bile juice infection and pancreatic fistula after pancreatoduodenectomy: a prospective observational study. Pancreas 2015;44(3): 465-470.

13. Motoi F, Egawa S, Rikiyama T, et al. Randomized clinical trial of external stent drainage of the pancreatic duct to reduce postoperative pancreatic fistula after pancreaticojejunostomy. Br J Surg 2012;99(4): 524-531.

14. Bassi C, Marchegiani G, Dervenis C, et al. The 2016 update of the International Study Group (ISGPS) definition and grading of postoperative pancreatic fistula: 11 Years After. Surgery 2017;161(3): 584-591.

15. Kanazawa H, Nagino M, Kamiya S, et al. Synbiotics reduce postoperative infectious complications: a randomized controlled trial in biliary cancer patients undergoing hepatectomy. Langenbecks Arch Surg 2005;390(2): 104-113.

16. Sugawara G, Nagino M, Nishio H, et al. Perioperative synbiotic treatment to prevent postoperative infectious complications in biliary cancer surgery: a randomized controlled trial. Ann Surg 2006;244(5): 706-714.

17. Sugawara G, Ebata T, Yokoyama Y, et al. The effect of preoperative biliary drainage on infectious complications after hepatobiliary resection with cholangiojejunostomy. Surgery 2013;153(2): 200-210.

18. National Healthcare Safety Network, Centers for Disease Control and Prevention. Surgical site infection (SSI) event. http://www.cdc.gov/nhsn/pdfs/pscmanual/9pscssicurrent.pdf. Published January 2018. Accessed August 29, 2018.

19. Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a ne proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Sur 2004;240(2): 205-213.

20. Thursby E, Juge N. Introduction to the human gut microbiota. Biochem 2017;474(11): 1823-1836.

21. Bindels LB, Neyrinck AM, Loumaye A, et al. Increased gut permeability in cancer cachexia: mechanisms and clinical relevance. Oncotarget 2018;9(26): 18224-18238.

22. Krezalek MA, Hyoju S, Zaborin A, et al. Can Methicillin-resistant Staphylococcus aureus Silently Travel From the Gut to the Wound and Cause Postoperative Infection? Modeling the "Trojan Horse Hypothesis". Ann Surg 2018;267(4): 749-758.

23. Yang Y, Jobin C. Microbial imbalance and intestinal pathologies: connections and contributions. Dis Model Mech 2014;7(10): 1131-1142.

24. Yamaguchi N, Yokoyama Y, Ebata T, et al. Intermittent Pringle maneuver is unlikely to induce bacterial translocation to the portal vein: a study using bacterium-specific ribosomal RNA-targeted reverse transcription-polymerase chain reaction. J Hepatobiliary Pancreat Sci 2015;22(6): 491-497.

25. Sano S, Sugiura T, Kawamura I, et al. Third-generation cephalosporin for antimicrobial prophylaxis in pancreatoduodenectomy in patients with internal preoperative biliary drainage. Surgery 2019;165(3): 559-564.

26. Hata T, Mizuma M, Motoi F, et al. Early postoperative drainage fluid culture positivity from contaminated bile juice is predictive of pancreatic fistula after pancreaticoduodenectomy. Surg Today 2020;50(3): 248-257.

27. Wada M, Lkhagvadorj E, Bian L, et al. Quantitative reverse transcription-PCR assay for the rapid detection of methicillin-resistant Staphylococcus aureus. J Appl Microbiol 2010;108(3): 779-788.

28. Chowdhury AH, Adiamah A, Kushairi A, et al. Perioperative Probiotics or Synbiotics in Adults Undergoing Elective Abdominal Surgery: A Systematic Review and Metaanalysis of Randomized Controlled Trials. Ann Surg 2019.

29. Yokoyama Y, Mizuno T, Sugawara G, et al. Profile of preoperative fecal organic acids closely predicts the incidence of postoperative infectious complications after major hepatectomy with extrahepatic bile duct resection: Importance of fecal acetic acid plus butyric acid minus lactic acid gap. Surgery 2017;162(4): 928-936.

30. Krezalek MA, DeFazio J, Zaborina O, et al. The Shift of an Intestinal "Microbiome" to a "Pathobiome" Governs the Course and Outcome of Sepsis Following Surgical Injury. Shock 2016;45(5): 475-482.

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