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Associations between genetic loci related to lean mass and body composition in type 2 diabetes

蓑原 達郎 近畿大学

2023.01.12

概要

Aim : Several genetic loci related to lean mass have been iden tifi ed in h ealthy individu als by genome-wide association studies; however, the con tribution of th ese loci to body composition in type 2 diabetes remains to be investigated. Here, we aimed to clarify th e genetic determin ants of body composition in in dividuals with type 2 diabetes.

Methods: A total of 176 Japan ese outpatients (70 women and 106 men ) with type 2 diabetes were stu died u sing a cross-section al design. Body composition was measured using bioimpedance analysis with a com mercially available device (InBody770). Sin gle-n ucleotide polymorph isms in IRS1 (rs2943656), HSD17B11 (rs9991501), VCAN (rs2287926), ADAM TSL3 (rs4842924) and FTO (rs9936385) were evalu ated by genotypin g. The contribu tion s of singlen ucleotide polymorphisms to body composition were examined, con sidering kn own clin ical determinants.

Results: Sex, body composition and age were iden tifi ed as clin ical predictors. IRS1 rs2934656 was identifi ed as an independen t predictor of skeletal mu scle mass (β= 0.11, P = 0.026), and ADAM TSL3 rs4842924 was an indepen dent predictor of body fat mass (β= 0.15, P = 0.0095) and appendicular lean mass (β= 0.13, P = 0.017).

Conclusions: Th e fi n dings clarifi ed th e contribu tion of genetic factors – IRS1 and ADAM TSL3 – to in terindividu al variation in body composition, in dependent of clinical factors, in type 2 diabetes patients. These data will con tribu te to th e establishmen t of effective methods for th e prediction, prevention, and interven tion of sarcopenia and frailty in diabetes patients. Geriatr Ger on t ol In t 2021; 21: 932–938.

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