Vitamin K intake and risk of lung cancer: the Japan Collaborative Cohort Study

概要

〔目的(Purpose)]
Limited reports from human prospective studies investigated the possible role of vitamin K in the development of 丄ung cancer although vitamin K5s anticarcinogenic activities were verified from several in vitro and in vivo studies. We investigated the associations between total vitamin K intake from food and the development of lung cancer based on this large prospective cohort study.

〔方法ならびに成績(Methods/Results)〕
Methods： A validated food frequency questionnaire was used to examine vitamin K intake among 42,166 (16,341 men and 25, 825 women) at the Japan Collaborative Cohort Study* s baseline (1988-1990). Hazard ratios (HRs) and 95% confidence intervals (Cis) of incident lung cancer were calculated using the Cox proportional hazard regression method based on vitamin K consumption quartiles.

Results： 430 cases (308 males and 122 women) of lung cancer were documented during a total of 564,127 person-years of follow-up (median follow-up:14. 6 years), Vitamin K consumption was shown to be inverse丄y related to lung cancer risk； the multivariable HR (95 % CI) for the highest vs. lowest quartiles was 0.67 (0.46-0. 0.96； p for trend = 0.010). This relationship appears to be stronger in ma [0. 62 (0.40-0.96)； p for trend=0.016] than in females [0.82 (0.42-1.61)；p for trend=0. 39] (p interaction 0. 012), and in ever smokers [0.57 (0.36-0.91)；p for trend=0.006] than in never smokers [0.79 (0.40-1.55) ； p for trend=0. 37] (p for interaction= 0.30). The individuals’ age, BMI, or alc consumption status had no effect on the observed connection.

〔総括(Conclusion)〕
Vitamin K consumption reduces the risk of lung cancer. More research is needed to clarify the molecular processes behind this connection.