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イネ科植物いもち病菌の病原性に関与するエピジェネティクス機構の研究

DANG NGOC MINH ダン, ナッ, ミン 神戸大学

2023.03.06

概要

The blast fungus, P. oryzae shows drastic morphological changes
during the infection cycle (Talbot, 2003). Following attachment on the host
leaf surface, a spore germinates and forms an appressorium at the tip of the
germ tube. At the base of the appressorium, a penetration pore and peg are
formed to colonize a host cell with infection hyphae. These morphological
changes are accompanied with remarkable changes in gene expression (Jeon
et al., 2020) that may involve cell type-specific epigenetic control of
chromatin structure.
In P. oryzae, gene deletion analysis of eight possible KMTs revealed
that MoSET1 responsible for H3K4 methylation plays a pivotal role in
infection-related morphogenesis of the fungus (Pham et al., 2015a). Loss of
MoSET1 led to a deficiency in cell growth, sporulation, appressorium
formation, production of cell wall degradation enzymes, and pathogenicity
(Vu et al., 2013; Pham et al., 2015a, b). RNA-seq analysis suggested that
approximately 2,000 genes were up- or down-regulated during appressorium
formation in a MoSET1-dependent manner. ...

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