1 Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram
I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN
estimates of incidence and mortality worldwide for 36 cancers
in 185 countries. CA Cancer J Clin. 2021;71:209-49. DOI:
10.3322/caac.21660, PMID: 33538338
2 Chan BA, Hughes BG. Targeted therapy for non-small cell
lung cancer: current standards and the promise of the future.
Transl Lung Cancer Res. 2015;4:36-54. PMID: 25806345
3 Liu W, Du Y, Wen R, Yang M, Xu J. Drug resistance
to targeted therapeutic strategies in non-small cell lung
cancer. Pharmacol Ther. 2020;206:107438. DOI: 10.1016/
j.pharmthera.2019.107438, PMID: 31715289
4 Smith SL, Watson SG, Ratschiller D, Gugger M, Betticher
DC, Heighway J. Maspin – the most commonly-expressed
gene of the 18q21.3 serpin cluster in lung cancer – is strongly
expressed in preneoplastic bronchial lesions. Oncogene.
2003;22:8677-87. DOI: 10.1038/sj.onc.1207127, PMID:
14647462
5 Zou Z, Anisowicz A, Hendrix M, Thor A, Neveu M, Sheng
S, et al. Maspin, a serpin with tumor-suppressing activity in
human mammary epithelial cells. Science. 1994;263:526-9.
DOI: 10.1126/science.8290962, PMID: 8290962
6 Sheng S, Pemberton PA, Sager R. Production, purification,
and characterization of recombinant maspin proteins.
J Biol Chem. 1994;269:30988-93. DOI: 10.1016/S00219258(18)47379-6, PMID: 7983035
7 Schneider SS, Schick C, Fish KE, Miller E, Pena JC, Treter
SD, et al. A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene. Proc Natl Acad Sci USA. 1995;92:314751. DOI: 10.1073/pnas.92.8.3147, PMID: 7724531
8 Latha K, Zhang W, Cella N, Shi HY, Zhang M. Maspin
mediates increased tumor cell apoptosis upon induction of
the mitochondrial permeability transition. Mol Cell Biol.
2005;25:1737-48. DOI: 10.1128/MCB.25.5.1737-1748.2005,
PMID: 15713631
9 Sheng S, Carey J, Seftor EA, Dias L, Hendrix MJ, Sager R.
Maspin acts at the cell membrane to inhibit invasion and motility of mammary and prostatic cancer cells. Proc Natl Acad
Sci USA. 1996;93:11669-74. DOI: 10.1073/pnas.93.21.11669,
PMID: 8876194
10 Shi HY, Zhang W, Liang R, Abraham S, Kittrell FS, Medina
D, et al. Blocking tumor growth, invasion, and metastasis
by maspin in a syngeneic breast cancer model. Cancer Res.
2001;61:6945-51. PMID: 11559574
11 Odero-Marah VA, Khalkhali-Ellis Z, Chunthapong J, Amir
S, Seftor REB, Seftor EA, et al. Maspin regulates different
signaling pathways for motility and adhesion in aggressive
breast cancer cells. Cancer Biol Ther. 2003;2:398-403. DOI:
10.4161/cbt.2.4.471, PMID: 14508113
12 Cella N, Contreras A, Latha K, Rosen JM, Zhang M, Cella
N, et al. Maspin is physically associated with β1 integrin
regulating cell adhesion in mammary epithelial cells. FASEB J.
2006;20:1510-2. DOI: 10.1096/fj.05-5500fje, PMID: 16720730
13 Nam E, Park C. Maspin suppresses survival of lung cancer
cells through modulation of Akt pathway. Cancer Res Treat.
2010;42:42-7. DOI: 10.4143/crt.2010.42.1.42, PMID: 20369051
14 Ben Shachar B, Feldstein O, Hacohen D, Ginsberg D. The
tumor suppressor maspin mediates E2F1-induced sensitivity
of cancer cells to chemotherapy. Mol Cancer Res. 2010;8:36372. DOI: 10.1158/1541-7786.MCR-09-0137, PMID: 20197383
Ack nowledg ments: This work was suppor ted by JSPS
KAKENHI (grant number: JP19K09304). This research was
partly performed at the Tottori Bio Frontier, managed by Tottori
prefecture.
The authors declare no conflict of interest.
© **** Tottori University Medical Press
Maspin function in lung adenocarcinoma
15 Liu H, Shi J, Anandan V, Wang HL, Diehl D, Blansfield J,
et al. Reevaluation and identification of the best immunohistochemical panel (pVHL, Maspin, S100P, IMP-3) for ductal
adenocarcinoma of the pancreas. Arch Pathol Lab Med.
2012;136:601-9. DOI: 10.5858/arpa.2011-0326-OA, PMID:
22646265
16 Berardi R, Morgese F, Onofri A, Mazzanti P, Pistelli M,
Ballatore Z, et al. Role of maspin in cancer. Clin Transl Med.
2013;2:8. DOI: 10.1186/2001-1326-2-8, PMID: 23497644
17 Umekita Y, Ohi Y, Sagara Y, Yoshida H. Expression of
maspin predicts poor prognosis in breast-cancer patients. Int
J Cancer. 2002;100:452-5. DOI: 10.1002/ijc.10500, PMID:
12115529
18 Takagi Y, Matsuoka Y, Shiomi T, Nosaka K, Takeda C,
Haruki T, et al. Cytoplasmic maspin expression is a predictor
of poor prognosis in patients with lung adenocarcinoma measuring <3 cm. Histopathology. 2015;66:732-9. DOI: 10.1111/
his.12586, PMID: 25322663
19 Matsuoka Y, Takagi Y, Nosaka K, Sakabe T, Haruki T, Araki
K, et al. Cytoplasmic expression of maspin predicts unfavourable prognosis in patients with squamous cell carcinoma
of the lung. Histopathology. 2016;69:114-20. DOI: 10.1111/
his.12921, PMID: 27297724
20 Ohno T, Kubouchi Y, Wakahara M, Nosaka K, Sakabe T,
Haruki T, et al. Clinical significance of subcellular localization of maspin in patients with pathological stage ia lung
adenocarcinoma. Anticancer Res. 2018;38:3001-7. PMID:
29715131
21 Goulet B, Kennette W, Ablack A, Postenka CO, Hague MN,
Mymryk JS, et al. Nuclear localization of maspin is essential
for its inhibition of tumor growth and metastasis. Lab Invest.
2011;91:1181-7. DOI: 10.1038/labinvest.2011.66, PMID:
21502940
22 Sakabe T, Wakahara M, Shiota G, Umekita Y. Role of
cytoplasmic localization of maspin in promoting cell invasion in breast cancer with aggressive phenotype. Sci Rep.
2021;11:11321. DOI: 10.1038/s41598-021-90887-z, PMID:
34059749
23 Bettstetter M, Woenckhaus M, Wild PJ, Rümmele P, Blaszyk
H, Hartmann A, et al. Elevated nuclear maspin expression
is associated with microsatellite instability and high tumour
grade in colorectal cancer. J Pathol. 2005;205:606-14. DOI:
10.1002/path.1732, PMID: 15714592
24 Zhu S, Wu H, Wu F, Nie D, Sheng S, Mo YY. MicroRNA-21
targets tumor suppressor genes in invasion and metastasis.
Cell Res. 2008;18:350-9. DOI: 10.1038/cr.2008.24, PMID:
18270520
25 Villares GJ, Zigler M, Dobroff AS, Wang H, Song R,
Melnikova VO, et al. Protease activated receptor-1 inhibits the
Maspin tumor-suppressor gene to determine the melanoma
metastatic phenotype. Proc Natl Acad Sci USA. 2011;108:62631. DOI: 10.1073/pnas.1006886108, PMID: 21187389
26 Dzinic SH, Kaplun A, Li X, Bernardo M, Meng Y, Dean I,
et al. Identification of an intrinsic determinant critical for
maspin subcellular localization and function. PLoS One.
2013;8:e74502. DOI: 10.1371/journal.pone.0074502, PMID:
24278104
27 Reina J, Zhou L, Fontes MRM, Panté N, Cella N. Identification of a putative nuclear localization signal in the tumor
suppressor maspin sheds light on its nuclear import regulation. FEBS Open Bio. 2019;9:1174-83. DOI: 10.1002/22115463.12626, PMID: 31144423
28 Li X, Yin S, Meng Y, Sakr W, Sheng S. Endogenous inhibition of histone deacetylase 1 by tumor-suppressive maspin.
Cancer Res. 2006;66:9323-9. DOI: 10.1158/0008-5472.CAN06-1578, PMID: 16982778
29 Biliran H Jr, Sheng S. Pleiotrophic inhibition of pericellular
urokinase-type plasminogen activator system by endogenous
tumor suppressive maspin. Cancer Res. 2001;61:8676-82.
PMID: 11751384
30 Son HJ, Moon A. Epithelial-mesenchymal transition and
cell invasion. Toxicol Res. 2010;26:245-52. DOI: 10.5487/
TR.2010.26.4.245, PMID: 24278531
31 Dongre A, Weinberg RA. New insights into the mechanisms
of epithelial–mesenchymal transition and implications for
cancer. Nat Rev Mol Cell Biol. 2019;20:69-84. DOI: 10.1038/
s41580-018-0080-4, PMID: 30459476
32 Pećina-Šlaus N. Tumor suppressor gene E-cadherin and its
role in normal and malignant cells. Cancer Cell Int. 2003;3:17.
DOI: 10.1186/1475-2867-3-17, PMID: 14613514
33 Vunnam N, Pedigo S. Calcium-induced strain in the monomer promotes dimerization in neural cadherin. Biochemistry.
2011;50:8437-44. DOI: 10.1021/bi200902s, PMID: 21870846
34 Nieman MT, Prudoff RS, Johnson KR, Wheelock MJ. N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression. J Cell Biol. 1999;147:63144. DOI: 10.1083/jcb.147.3.631, PMID: 10545506
35 Hazan RB, Phillips GR, Qiao RF, Norton L, Aaronson SA.
Exogenous expression of N-cadherin in breast cancer cells
induces cell migration, invasion, and metastasis. J Cell
Biol. 2000;148:779-90. DOI: 10.1083/jcb.148.4.779, PMID:
10684258
36 Li G, Satyamoorthy K, Herlyn M. N-cadherin-mediated
intercellular interactions promote survival and migration
of melanoma cells. Cancer Res. 2001;61:3819-25. PMID:
11325858
37 Nakajima S, Doi R, Toyoda E, Tsuji S, Wada M, Koizumi
M, et al. N-cadherin expression and epithelial-mesenchymal
transition in pancreatic carcinoma. Clin Cancer Res.
2004;10:4125-33. DOI: 10.1158/1078-0432.CCR-0578-03,
PMID: 15217949
38 Da C, Wu K, Yue C, Bai P, Wang R, Wang G, et al. Ncadherin promotes thyroid tumorigenesis through modulating
major signaling pathways. Oncotarget. 2017;8:8131-42. DOI:
10.18632/oncotarget.14101, PMID: 28042956
39 Wei J, Xu G, Wu M, Zhang Y, Li Q, Liu P, et al. Overexpression of vimentin contributes to prostate cancer invasion and
metastasis via src regulation. Anticancer Res. 2008;28:327-34.
PMID: 18383865
40 Tadokoro A, Kanaji N, Liu D, Yokomise H, Haba R, Ishii
T, et al. Vimentin regulates invasiveness and is a poor prognostic marker in non-small cell lung cancer. Anticancer Res.
2016;36:1545-51. PMID: 27069130
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