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活性化型マウスIL-18のネオエピトープに対する拮抗性モノクローナル抗体の作製とその評価方法の開発

内田 有紀 島根大学

2023.09.06

概要

Interleukin 18 (IL-18), a member of the IL-1 family, has important
functions in both the innate and acquired immune systems [1–3]. IL-18
is constitutively expressed as an inactive precursor (24 kDa) in a wide
variety of cell types, including monocytes, macrophages, intestinal
epithelial cells, keratinocytes, and synovial fibroblasts [1]. When
inflammation is triggered, a large protein complex called the inflam­
masome is formed and caspase-1/4 is activated. ...

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