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Regulation of sleep by traumatic stress

Lou, Tingting 筑波大学 DOI:10.15068/0002000791

2021.07.29

概要

Sleep disturbances have been recognized as a core symptom of post-traumatic stress disorder (PTSD). However, the neural basis of PTSD-related sleep disturbances remains unclear. It has been challenging to establish the causality link between a specific brain region and traumatic stress-induced sleep abnormality. Here, we found that single prolonged stress (SPS) could induce acute changes in sleep/wake duration as well as short and long-term electroencephalogram (EEG) alterations in the isogenic mouse model. Moreover, the medial prefrontal cortex (mPFC) showed a persistently high number of c-fos expressing neurons, of which more than 95% are excitatory neurons, during and immediately after SPS. Chemogenetic inhibition of the prelimbic region of mPFC during SPS could specifically reverse the SPS-induced acute suppression of delta power (1-4Hz EEG) of non-rapid-eye-movement sleep (NREMS) as well as most long-term EEG abnormalities. These findings suggest a causality link between hyper-activation of mPFC neurons and traumatic stress-induced specific sleep-wake EEG disturbances.

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