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Chemogenetic activation of the mPFC alleviates impaired fear memory extinction in an animal model of PTSD

大村 淳 広島大学

2020.11.26

概要

While the lifetime prevalence of posttraumatic stress disorder
(PTSD) varies according to social background and country of residence,
ranging from 1.3% to 12.2%, it is the most prevalent psychopathological consequence of exposure to traumatic events (Karam et al., 2014),
(Shalev et al., 2017). Since long-lasting emotional and psychomotor
disturbances due to PTSD can induce functional difficulties at work,
school, or home, the costs of PTSD to society are substantial (Kessler,
2000). In addition, PTSD is highly comorbid with depression, other
anxiety disorders, and substance abuse, and it is one of the leading
causes of suicide (Sareen et al., 2007). ...

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