論文の公開元へA study about the immunomodulatory function of dietary compounds with hypolipidemic effect
概要
1.5. Aim of Doctoral Thesis
Several dietary compounds could exhibit good immunomodulatory effects in addition to
their cholesterol-lowering effects. However, studies on the immunomodulatory effects
(e.g., anti-inflammatory and/or anti-allergic effects) of cholesterol-lowering molecules are
still limited. Therefore, this study aimed to investigate the immunomodulatory effects of
(i) β-1,3 glucan, β-1,3/1,6-glucan, and (ii) bisacurone.
β-1,3 glucan and β-1,3/1,6-glucan are soluble dietary fiber. These β-glucans bind to Tolllike receptor (TLR)2 and Dectin-1 expressed on the cell surface of dendritic cells (DC)
and macrophages. Several studies have shown the immunostimulatory effects of β-1,3
glucan and β-1,3/1,6-glucan, whereas the immunomodulatory effect of β-1,3 glucan and
β-1,3/1,6-glucan is expected owing to its effect on the modulation of the gut microbiome.
In particular, the anti-allergic effect of β-1,3 glucan and β-1,3/1,6-glucan have been
debated. ...
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