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Does sarcopenia affect postoperative short- and long-term outcomes in patients with lung cancer?-a systematic review and meta-analysis.

KAWAGUCHI Yo 0000-0002-7828-4635 HANAOKA Jun 00452243 0000-0002-5272-556X OHSHIO Yasuhiko 60731916 OKAMOTO Keigo 000-0002-6992-3765 KAKU Ryosuke HAYASHI Kazuki 0000-0002-2393-1233 SHIRATORI Takuya AKAZAWA Akira 滋賀医科大学

2021.03

概要

Background:
Lung cancer patients frequently suffer from sarcopenia, and reports on the association of resectable lung cancer and their postoperative outcomes are increasing. Information on whether sarcopenia has any impact on short- and long-term postoperative outcomes in patients surgically treated for non-small cell lung cancer remains insufficient. Furthermore, reports vary regarding the pathological stage, surgical procedure, diagnostic tool of sarcopenia, cut-off value, prognosis, and postoperative complications. We believe that sarcopenia assessment should be included as one of the factors which affect the surgical outcomes of lung cancer. Thus, we conducted a review and meta-analysis to ascertain the association between sarcopenia and postoperative outcomes.
Methods:
We performed a systematic literature search in PubMed/MEDLINE. Studies included cases defined sarcopenia, received lung cancer surgery, assessed postoperative complications, and prognosis. The pooled odds ratios for survival and postoperative complications, with 95% confidence intervals, were generated using Review manager 5.3.
Results:
A total of ten retrospective studies were eligible for this meta-analysis, including a total of 2,643 non-small cell lung cancer patients. All reviews used skeletal muscle mass as a diagnostic tool for sarcopenia. Sarcopenia was associated with worse survival outcomes and increased postoperative complications in patients with resected lung cancer.
Conclusions:
Sarcopenia is an independent risk factor for postoperative death and postoperative complications in patients who have undergone surgery. It is necessary to explore the mechanism of sarcopenia and optimal intervention, such as exercise, nutrition, or drug therapy.

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Cite this article as: Kawaguchi Y, Hanaoka J, Ohshio Y,

Okamoto K, Kaku R, Hayashi K, Shiratori T, Akazawa A. Does

sarcopenia affect postoperative short- and long-term outcomes

in patients with lung cancer?—a systematic review and metaanalysis. J Thorac Dis 2021;13(3):1358-1369. doi: 10.21037/jtd-203072

© Journal of Thoracic Disease. All rights reserved.

J Thorac Dis 2021;13(3):1358-1369 | http://dx.doi.org/10.21037/jtd-20-3072

...

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