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Preoperative frailty as a predictive factor for postoperative complications in patients with pancreatic cancer

Onji, Makoto Kakizoe, Shinji Naito, Koichi Date, Kenjiro Nakai, Asuka Shimizu, Kanami Suyama, Masatake Nakamura, So Kuga, Hirotaka Nishihara, Kazuyoshi 名古屋大学

2023.08

概要

Improvements in the survival rate of patients with pancreatic cancer (PC) have been reported
due to advancements in chemotherapy and surgical techniques.1 Pancreatectomy is a highly invasive procedure and has a high incidence rate of postoperative complications, such as pancreatic
fistula and subsequent intra-abdominal abscess, ranging from 18% to 60%.2 Therefore, it requires
prolonged hospitalization. Cardiopulmonary function and lower limb muscle strength have been
reported to significantly decrease 3 months after pancreatectomy.3 Thus, careful attention should
be paid to postoperative complications and physical conditions during the perioperative period.
Frailty is defined as a clinical syndrome of progressive decline in physical and mental functioning, regardless of comorbidities,4 and it is a particularly important issue in an aging society.
Frailty is a good predictor of postoperative complications after hepatectomy5 and a possible
prognostic factor.6 Therefore, in providing perioperative physical therapy, frailty is considered one
of the most important indicators to understand the patient’s general condition, such as physical
function and exercise tolerance.
Although several studies have investigated the association between preoperative frailty and
postoperative complications, only a few have focused exclusively on PC.7-9 Moreover, they focused
on relatively severe postoperative complications.8,9 Therefore, this study aimed to investigate
whether preoperative frailty is a useful predictor of all postoperative complications, with an
exclusive focus on patients with PC. ...

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参考文献

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References End

Nagoya J. Med. Sci. 85. 518–527, 2023

527

doi:10.18999/nagjms.85.3.518

...

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