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Impact of fractional exhaled nitric oxide on the outcomes of lung resection surgery: a prospective study.

OKAMOTO Keigo 000-0002-6992-3765 HAYASHI Kazuki 0000-0002-2393-1233 KAKU Ryosuke KAWAGUCHI You 0000-0002-7828-4635 OSHIO Yasuhiko 60731916 HANAOKA Jun 00452243 0000-0002-5272-556X 滋賀医科大学

2020.05

概要

Background:
Fractional exhaled nitric oxide (FeNO), which is representative of airway inflammation, is an indicator of chronic lung disease. However, its effect on the outcome of lung resection is unknown. The aim of this prospective study was to evaluate FeNO in patients who underwent lung resection, to analyze the perioperative dynamics, and clarify the impact on postoperative complications.
Methods:
We measured FeNO using NIOX VERO® once before and on days 1, 3, 5–7 after surgery in participants who were candidates for lung cancer surgery. The primary endpoint was the relationship between postoperative morbidity and preoperative FeNO. The secondary endpoint was the relationship between postoperative FeNO and additional treatment, including readmission.
Results:
We enrolled 105 patients between September 2017 and March 2019. Anatomical lung resection was the predominant treatment (87%) for primary lung cancer. Postoperative pulmonary complications developed in 16 patients. Multivariate analysis revealed that preoperative FeNO was a significant predictor of postoperative pulmonary complications (P=0.002, OR: 1.004, 95% CI: 1.016–1.074). FeNO levels increased significantly after surgery (P=0.011). Postoperative FeNO was a significant predictor of the need for additional medical treatment within 30 days of surgery (P=0.001, OR: 1.068, 95% CI: 1.028–1.110).
Conclusions:
Perioperative FeNO was a significant predictor of surgical outcome among patients who underwent lung resection. The measurement of FeNO is expected to be a simple and useful method for preventing subsequent deterioration in these patients.

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J Thorac Dis 2020;12(5):2663-2671 | http://dx.doi.org/10.21037/jtd.2020.03.18

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Cite this article as: Okamoto K, Hayashi K, Kaku R,

Kawaguchi Y, Oshio Y, Hanaoka J. Impact of fractional exhaled

nitric oxide on the outcomes of lung resection surgery: a

prospective study. J Thorac Dis 2020;12(5):2663-2671. doi: 10.21037/

jtd.2020.03.18

J Thorac Dis 2020;12(5):2663-2671 | http://dx.doi.org/10.21037/jtd.2020.03.18

...

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Impact of fractional exhaled nitric oxide on the outcomes of lung resection surgery: a prospective study.

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Impact of fractional exhaled nitric oxide on the outcomes of lung resection surgery: a prospective study.

概要

この論文で使われている画像

関連論文

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