リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

大学・研究所にある論文を検索できる 「The ameliorative effects of glutathione on biochemical indices of goats exposed to lead」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

コピーが完了しました

URLをコピーしました

論文の公開元へ論文の公開元へ
書き出し

The ameliorative effects of glutathione on biochemical indices of goats exposed to lead

Ganiyat, Akande Motunrayo Kabiru, Wazehorbor James Onyi, Chianumba Franklin Mgbore, Okoronkwo Stella 北海道大学

2020.11

概要

Poisoning with lead is rampant in goats and it is a crucial threat to their economic and nutritional worth. Lead exerts deleterious impacts on the bodies of human beings and animals. Glutathione possesses antioxidant and decontamination characteristics in living systems. It is opined that glutathione might abrogate lead toxicity through its beneficial mechanisms of action. The purpose of this study was to find out the influence of glutathione on biochemical indices in goats exposed to lead. Twenty bucks were included in the research and were distributed into five groups (four animals/group) as follows: Control (CONT group, administered with distilled water); Lead (10 mg kg-1) group; Lead (10 mg kg-1)+Glutathione (50 mg kg-1) group; Lead (10 mg kg-1)+Glutathione (100 mg kg-1) group and Lead (10 mg kg-1)+Glutathione (200 mg kg-1) group. The animals received lead and glutathione daily per os for 21 days. The biochemical indices were estimated with a Clinical Chemistry Analyzer. Lead evoked considerable elevations in the activities of some of the serum enzymes and levels of urea, triglycerides and thyroid stimulating hormone. Also, the levels of albumin, triiodothyronine and thyroxine were decreased appreciably in the lead group. Glutathione ameliorated the undesirable effects of lead in the goats. The advantageous effects of glutathione in this research may be attributed to its bioprotective impacts. Therefore glutathione may be a valuable agent for the amelioration of lead intoxication in goats.

参考文献

1) Abd El-Ghffar EA, Abd El-Aal A. Ameliorating effect of L-Cysteine on lead acetate-induced hepatotoxicity and nephrotoxicity in male mice. Progress in Nutrition 20, 79-89, 2018.

2) Abdelhamid FM, Mahgoub HA, Ateya AI. Ameliorative effect of curcumin against lead acetate–induced hemato-biochemical alterations, hepatotoxicity, and testicular oxidative damage in rats. Environ Sci Pollut Res Int 27, 10950-10965, 2020.

3) Ahmadvand H, Babaeenezhad E, Nasri M, Jafaripour L, Khorramabadi RM. Glutathione ameliorates liver markers, oxidative stress and inflammatory indices in rats with renal ischemia reperfusion injury. Journal of Renal Injury and Prevention 8, 91-97, 2019.

4) Ahmed GM, Mahmood AS. Effect of lead acetate on some biochemical factors in blood of rats. International Journal of Current Research 6, 4338-4340, 2014.

5) Akande MG, Aliu YO, Ambali SF, Ayo JO. Co- treatment of chlorpyrifos and lead induced serum lipid disorders in rats: alleviation by taurine. Toxicol Ind Health 32, 1328-1334, 2014a.

6) Akande MG, Aliu YO, Ambali SF, Ayo JO. Taurine alleviated biochemical alterations in male Wistar rats co-exposed to chlorpyrifos and lead. Journal of Toxicology and Environmental Health Sciences 6, 13-25, 2014b.

7) Akande MG, Shittu M, Uchendu C, Yaqub LS. Taurine ameliorated thyroid function in rats co-administered with chlorpyrifos and lead. Vet Res Commun 40,123-129, 2016.

8) Al Zadjali S, Nemmar A, Fahim MAAY, Azimullah S, Subramanian D, Yasin J, Amir N, Hasan MY, Adem A. Lead exposure causes thyroid abnormalities in diabetic rats. Int J Clin Exp Med 8, 7160-7167, 2015.

9) Alqayim MAJ. Antiatherogenic effects of Vitamin E against lead acetate induced hyperlipidemia. Mesopotamia Environmental Journal 1, 85-95, 2015.

10) Alwaleedi SA. Hematobiochemical changes induced by lead intoxication in male and female albino mice. National Journal of Physiology, Pharmacy and Pharmacology 6, 46-51, 2016.

11) Bandyopadhyay D, Ghosh D, Chattopadhyay A, Firdaus SB, Ghosh AK, Paul S, Bhowmik D, Mishra S, Dalui K. Lead induced oxidative stress: a health issue of global concern. Journal of Pharmacy Research 8, 1198-1207, 2014.

12) Chen J, Wu F, Long Y, Yu W. Glutathione supplementation attenuates oxidative stress and improves vascular hyporesponsiveness in experimental obstructive jaundice. Oxid Med Cell Longev PMID: 26161237, 10 pages, 2015.

13) Dooyema CA, Neri A, Lo YC, Durant J, Dargan PI, Swarthout T, Biya O, Gidado SO, Haladu S, Sani-Gwarzo N, Nguku PM, Akpan H, Idris S, Bashir AM, Brown MJ. Outbreak of fatal childhood lead poisoning related to artisanal gold mining in northwestern Nigeria. Environ Health Perspect 120, 601-607, 2012.

14) Ezejiofor AN, Orisakwe OE. Nephroprotective effect of Costus afer on lead induced kidney damage in albino rats. Int J Physiol Pathophysiol Pharmacol 11, 36-44, 2019.

15) Fiolomeni G, Rotilio G, Cirolo MR. Cell signalling and the glutathione redox system. Biochem Pharmacol 64, 1057-1064, 2002.

16) Flora G, Gupta D, Tiwari A. Toxicity of lead: a review with recent updates. Interdiscip Toxicol 5, 47-58, 2012.

17) Friedewald WT, Levy RI, Fredickson DS. Estimation of the concentration of low density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin Chem 18, 499-502, 1972.

18) Garber JC, Barbee RW, Bielitzki JT, Clayton LA, Donovan JC, Kohn DF, Lipman NS, Locke P, Melcher J, Quimby FW, Turner PV, Wood GA, Wurbel H. Guide for the care and use of laboratory animals, 8th ed. National Academies Press, Washington DC., 2011.

19) Ghosh D, Dey M, Ghosh AK, Chattopadhyay A, Bandyopadhyay D. Melatonin protects against lead acetate-induced changes in blood corpuscles and lipid profile of male Wistar rats. Journal of Pharmacy Research 8, 336- 342, 2014.

20) Haneef SS, Swarup D, Dwivedi SK, Dash PK. Effects of concurrent exposure to lead and cadmium on renal function in goats. Small Ruminant Research 28, 257-261, 1998.

21) Hasanein P, Kazemian-Mahtaj A, Khodadadi I. Bioactive peptide carnosine protects against lead acetate-induced hepatotoxicity by abrogation of oxidative stress in rats. Pharm Biol 54, 1458-1464, 2016.

22) Ibrahim NM, Eweis EA, El-Beltagi HS, Abdel- Mobdy YE. Effect of lead acetate toxicity on experimental male albino rat. Asian Pac J Trop Biomed 2, 41-46, 2012.

23) Jiang Z, Kohzuki M, Harada T, Sato T. Glutathione suppresses increase of serum creatine kinase in experimental hypoglycemia. Diabetes Res Clin Pract 77, 357-362, 2007.

24) Jovanović JM, Nikolić RS, Kocić GM, Krstić NS, Krsmanović MM. Glutathione protects liver and kidney tissue from cadmium and lead-provoked lipid peroxidation. J Serb Chem Soc 78, 197-207, 2013.

25) Jubril AJ, Kabiru M, Olopade JO, Taiwo VO. Biological monitoring of heavy metals in goats exposed to environmental contamination in Bagega, Zamfara State, Nigeria. Advances in Environmental Biology 11, 11-18, 2017.

26) Karamala SK, Sri latha CH, Anjaneyulu Y, Chandra Sekhara Rao TS, Sreeni Vasulu D, Amravathi PP. Hematobiochemical changes of lead poisoning and amelioration with Ocimum sanctum in Wistar albino rats. Veterinary World 4, 260-263, 2011.

27) Katole SB, Kumar P, Patil RD. Environmental pollutants and livestock health: a review. Veterinary Research International 1, 1-13, 2013.

28) Kleinman WA, Richie JP Jr. Status of glutathione and other thiols and disulfides in human plasma. Biochem Pharmacol 60, 19-29, 2000.

29) Lee RD, Nieman DC. Nutrition Assessment, 6th ed. McGraw-Hill, Boston., 2012.

30) Liu B, Qin H, Zhang B, Shi T, Cui Y. Enhanced oxidative stress by lead toxicity retards cell survival in primary thyroid cells. International Journal of Clinical and Experimental Medicine 10, 4590-4597, 2017.

31) Loguercio C, D'Argenio G, Delle Cave M, Cosenza V, Della Valle N, Mazzacca G, Del Vecchio Blanco C. Glutathione supplementation improves oxidative damage in experimental colitis. Dig Liver Dis 35, 635- 641, 2003.

32) Medecins Sans Frontières (MSF). Lead poisoning crisis in Zamfara State, Northern Nigeria. https://www.msf.org.uk/sites/uk/files/ Lead_Poisoning_Crisis_in_Zamfara_State_ Northern_Nigeria_201212133049.pdf. 2012. Accessed on July 20, 2020.

33) Meister A, Anderson MD. Glutathione. Ann Rev Biochem 52, 711-760, 1983.

34) Mohamed RS, Foud K, Akl EM. Hepatorenal protective effect of flaxseed protein isolate incorporated in lemon juice against lead toxicity in rats. Toxicology Reports 7, 30-35, 2020.

35) Nikolić R, Krstić N, Jovanović J, Kocić G, Cvetković TP, Radosavljević-Stevanović N. Monitoring the toxic effects of Pb, Cd and Cu on hematological parameters of Wistar rats and potential protective role of lipoic acid and glutathione. Toxicol Ind Health 31, 239-246, 2015.

36) Okediran BS, Suleiman KY, Adah AS, Sanusi F. Mitigation of lead acetate induced toxicity by ginger (Zingiber officinale). Annals of Clinical Toxicology 2, 1-5, 2019.

37) Sajid M, Younus M, Khan MUR, Anjum AA, Ehtisham-ul-Haque S. Effects of experimental lead toxicity on haematology and biochemical parameters in Lohi sheep. International Journal of Agriculture and Biology 19, 1409- 1413, 2017.

38) Sajitha GR, Jose R, Andrews A, Ajantha KG, Augustine P, Augusti KT. Garlic oil and Vitamin E prevent the adverse effects of lead acetate and ethanol separately as well as in combination in the drinking water of rats. Indian J Clin Biochem 25, 280-288, 2010.

39) Samipillai SS, Jagadeesan G. Protective effect of taurine and glutathione against mercury induced toxicity in the brain tissue of rats. International Journal of Modern Research and Reviews 4, 1082-1087, 2016.

40) Samir D, Khaoula Z. Evaluation of the chelating efficacy of Aquilaria malaccensis and Aristolochia longa against biochemical alterations induced by lead bioaccumulation in rats. Pharmaceutical and Biosciences Journal 7, 11-15, 2019.

41) Sharma S, Sharma V, Pracheta RP. Lead toxicity, oxidative damage and health implications. a review. International Journal of Biotechnology and Molecular Biology Research 2, 215-221, 2011.

42) Soliman AM, Abu-Basha EA, Youssef SAH, Amer AM, Murphy PA, Hauck CC, Gehring R, Hsu WH. Effect of chronic lead intoxication on the distribution and elimination of amoxicillin in goats. J Vet Sci 14, 395-403, 2013.

43) Soussi A, Gargouri M, El Feki A. Effects of co-exposure to lead and zinc on redox status, kidney variables, and histopathology in adult albino rats. Toxicol Ind Health 34, 469-480, 2018.

44) Sugiyama K, Ohishi K, Muramatsu K. Effects of dietary glutathione on plasma and liver lipid levels in rats fed on a high cholesterol diet. Agricultural and Biological Chemistry 51, 1601-1606, 1987.

45) Tatjana J, Gordana K, Dusica P, Ivana S. Effects of captopril on membrane associated enzymes in lead induced hepatotoxicity in rats. Scientific Journal of Faculty of Medicine 20, 183-188, 2003.

46) Varghese S, Oommen OV. Thyroid hormones regulate lipid metabolism in teleost Anabas testudinens (Bloch). Comp Biochem Physiol B Biochem Mol Biol 124B, 445-450, 1999.

47) Varghese S, Shameena B, Oommen OV. Thyroid hormones regulate lipid peroxidation and antioxidant enzyme activities in Anabas testudinens (Bloch). Comp Biochem Physiol B Biochem Mol Biol 128, 165-171, 2001.

48) Visser TJ. Deiodination of thyroid hormone and the role of glutathione. Trends in Biochemical Sciences 5, 222-224, 1980.

49) Vlasak T, Jordakieva G, Gnambs T, Augner C, Crevenna R, Winker R, Barth A. Blood lead levels and cognitive functioning: a meta- analysis. Sci Total Environ 668, 678-684, 2019.

50) Zaki MS, Mostafa S, Awad I. Some studies on lead toxicity in Marino sheep. Journal of American Science 6, 128-131, 2010.

参考文献をもっと見る

全国の大学の
卒論・修論・学位論文

一発検索!

この論文の関連論文を見る