Akiba, R., Matsuyama, T., Tu, H.Y., Hashiguchi, T., Sho, J., Yamamoto, S., Takahashi, M., and Mandai, M. (2019). Quantitative and qualitative evaluation of photoreceptor synapses in developing, degenerating and regenerating retinas. Front. Cell. Neurosci. 13, 1–20.
Ambati, J., Anand, A., Fernandez, S., Sakurai, E., Lynn, B.C., Kuziel, W.A., Rollins, B.J., and Ambati, B.K. (2003). An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice. Nat. Med. 9, 1390–1397.
Assawachananont, J., Mandai, M., Okamoto, S., Yamada, C., Eiraku, M., Yonemura, S., Sasai, Y., and Takahashi, M. (2014). Transplantation of embryonic and induced pluripotent stem cell-derived 3D retinal sheets into retinal degenerative mice. Stem Cell Reports 2, 662–674.
Bradford, S.T.J., Ranghini, E.J., Grimley, E., Lee, P.H., and Dressler, G.R. (2019). High-throughput screens for agonists of bone morphogenetic protein (BMP) signaling identify potent benzoxazole compounds. J. Biol. Chem. 294, 3125–3136.
Cunha-Vaz, J.G. (2004). The blood-retinal barriers system. Basic concepts and clinical evaluation. Exp. Eye Res. 78, 715–721.
Das, T., Del Cerro, M., Jalali, S., Rao, V.S., Gullapalli, V.K., Little, C., Loreto, D.A.D., Sharma, S., Sreedharan, A., Del Cerro, C., et al. (1999). The transplantation of human fetal neuroretinal cells in advanced retinitis pigmentosa patients: Results of a long-term safety study. Exp. Neurol. 157, 58– 68.
Edwards, A.O., Ritter, R., Abel, K.J., Manning, A., Panhuysen, C., and Farrer, L.A. (2005). Complement factor H polymorphism and age-related macular degeneration. Science (80-. ). 308, 385–389.
Eiraku, M., Takata, N., Ishibashi, H., Kawada, M., Sakakura, E., Okuda, S., Sekiguchi, K., Adachi, T., and Sasai, Y. (2011). Self-organizing optic-cup morphogenesis in three-dimensional culture. Nature 472, 51–56.
Elshatory, Y., Everhart, D., Deng, M., Xie, X., Barlow, R.B., and Gan, L. (2007). Islet-1 controls the differentiation of retinal bipolar and cholinergic amacrine cells. J. Neurosci. 27, 12707–12720.
Feng, L., Cook, B., Tsai, S.Y., Zhou, T., LaFlamme, B., Evans, T., and Chen, S. (2016). Discovery of a Small-Molecule BMP Sensitizer for Human Embryonic Stem Cell Differentiation. Cell Rep. 15, 2063–2075.
Fujii, S., Yoshida, S., Inagaki, E., Hatou, S., Tsubota, K., Takahashi, M., Shimmura, S., and Sugita, S. (2019). Immunological Properties of Neural Crest Cells Derived from Human Induced Pluripotent Stem Cells. Stem Cells Dev. 28, 28–43.
Fujii, S., Sugita, S., Futatsugi, Y., Ishida, M., Edo, A., Makabe, K., Kamao, H., Iwasaki, Y., Sakaguchi, H., Hirami, Y., et al. (2020). A strategy for personalized treatment of iPS-retinal immune rejections assessed in cynomolgus monkey models. Int. J. Mol. Sci. 21, 1–16.
Genthe, J.R., Min, J., Farmer, D.M., Shelat, A.A., Grenet, J.A., Lin, W., Finkelstein, D., Vrijens, K., Chen, T., Guy, R.K., et al. (2017). Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway. ACS Chem. Biol. 12, 2436–2447.
Hasan, N., Pangeni, G., Cobb, C.A., Ray, T.A., Nettesheim, E.R., Ertel, K.J., Lipinski, D.M., McCall, M.A., and Gregg, R.G. (2019). Presynaptic Expression of LRIT3 Transsynaptically Organizes the Postsynaptic Glutamate Signaling Complex Containing TRPM1. Cell Rep. 27, 3107-3116.e3.
Humayun, M.S., De Juan E., J., Del Cerro, M., Dagnelie, G., Radner, W., Sadda, S.R., and Del Cerro, C. (2000). Human neural retinal transplantation. Investig. Ophthalmol. Vis. Sci. 41, 3100– 3106.
Iraha, S., Tu, H.Y., Yamasaki, S., Kagawa, T., Goto, M., Takahashi, R., Watanabe, T., Sugita, S., Yonemura, S., Sunagawa, G.A., et al. (2018). Establishment of Immunodeficient Retinal Degeneration Model Mice and Functional Maturation of Human ESC-Derived Retinal Sheets after Transplantation. Stem Cell Reports 10, 1059–1074.
Ishikawa, M., Sawada, Y., and Yoshitomi, T. (2015). Structure and function of the interphotoreceptor matrix surrounding retinal photoreceptor cells. Exp. Eye Res. 133, 3–18.
Itakura, G., Ozaki, M., Nagoshi, N., Kawabata, S., Nishiyama, Y., Sugai, K., Iida, T., Kashiwagi, R., Ookubo, T., Yastake, K., et al. (2017). Low immunogenicity of mouse induced pluripotent stem cell- derived neural stem/progenitor cells. Sci. Rep. 7, 1–13.
Kashani, A.H., Lebkowski, J.S., Rahhal, F.M., Avery, R.L., Salehi-Had, H., Dang, W., Lin, C.M., Mitra, D., Zhu, D., Thomas, B.B., et al. (2018). A bioengineered retinal pigment epithelial monolayer for advanced, dry age-related macular degeneration. Sci. Transl. Med. 10, 1–10.
Kuwahara, A., Ozone, C., Nakano, T., Saito, K., Eiraku, M., and Sasai, Y. (2015). Generation of a ciliary margin-like stem cell niche from self-organizing human retinal tissue. Nat. Commun. 6, 1–15. Kuwahara, A., Yamasaki, S., Mandai, M., Watari, K., Matsushita, K., Fujiwara, M., Hori, Y., Hiramine, Y., Nukaya, D., Iwata, M., et al. (2019). Preconditioning the Initial State of Feeder-free Human Pluripotent Stem Cells Promotes Self-formation of Three-dimensional Retinal Tissue. Sci. Rep. 9, 1–16.
Mandai, M., Homma, K., Okamoto, S., Yamada, C., Nomori, A., and Takahashi, M. (2012). Adequate Time Window and Environmental Factors Supporting Retinal Graft Cell Survival in rd Mice. Cell Med. 4, 45–54.
Mandai, M., Fujii, M., Hashiguchi, T., Sunagawa, G.A., Ito, S., Sun, J., Kaneko, J., Sho, J., Yamada, C., and Takahashi, M. (2017a). iPSC-Derived Retina Transplants Improve Vision in rd1 End-Stage Retinal-Degeneration Mice. Stem Cell Reports 8, 69–83.
Mandai, M., Watanabe, A., Kurimoto, Y., Hirami, Y., Morinaga, C., Daimon, T., Fujihara, M., Akimaru, H., Sakai, N., Shibata, Y., et al. (2017b). Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration. N. Engl. J. Med. 376, 1038–1046.
Matsuyama, T., Tu, H.-Y., Sun, J., Hashiguchi, T., Akiba, R., Sho, J., Fujii, M., Onishi, A., Takahashi, M., and Mandai, M. (2021). Genetically engineered stem cell derived retinal grafts for improved retinal reconstruction after transplantation. IScience 24, 102866.
Miyazaki, T., Futaki, S., Suemori, H., Taniguchi, Y., Yamada, M., Kawasaki, M., Hayashi, M., Kumagai, H., Nakatsuji, N., Sekiguchi, K., et al. (2012). Laminin E8 fragments support efficient adhesion and expansion of dissociated human pluripotent stem cells. Nat. Commun. 3.
Mochizuki, M., Sugita, S., and Kamoi, K. (2013). Immunological homeostasis of the eye. Prog. Retin. Eye Res. 33, 10–27.
Morizane, A., Kikuchi, T., Hayashi, T., Mizuma, H., Takara, S., Doi, H., Mawatari, A., Glasser, M.F., Shiina, T., Ishigaki, H., et al. (2017). MHC matching improves engraftment of iPSC-derived neurons in non-human primates. Nat. Commun. 8, 1–12.
Nakagawa, M., Taniguchi, Y., Senda, S., Takizawa, N., Ichisaka, T., Asano, K., Morizane, A., Doi, D., Takahashi, J., Nishizawa, M., et al. (2014). A novel efficient feeder-Free culture system for the derivation of human induced pluripotent stem cells. Sci. Rep. 4, 1–7.
Nakajima, Y., Iwakabe, H., Akazawa, C., Nawa, H., Shigemoto, R., Mizuno, N., and Nakanishi, S. (1993). Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4- phosphonobutyrate. J. Biol. Chem. 268, 11868–11873. Nakano, T., Ando, S., Takata, N., Kawada, M., Muguruma, K., Sekiguchi, K., Saito, K., Yonemura, S., Eiraku, M., and Sasai, Y. (2012). Self-formation of optic cups and storable stratified neural retina from human ESCs. Cell Stem Cell 10, 771–785.
Ozaki, M., Iwanami, A., Nagoshi, N., Kohyama, J., Itakura, G., Iwai, H., Nishimura, S., Nishiyama, Y., Kawabata, S., Sugai, K., et al. (2017). Evaluation of the immunogenicity of human iPS cell- derived neural stem/progenitor cells in vitro. Stem Cell Res. 19, 128–138.
Palczewski, K., Van Hooser, J.P., Garwin, G.G., Chen, J., Liou, G.I., and Saari, J.C. (1999). Kinetics of visual pigment regeneration in excised mouse eyes and in mice with a targeted disruption of the gene encoding interphotoreceptor retinoid-binding protein or arrestin. Biochemistry 38, 12012–12019.
Radtke, N.D., Aramant, R.B., Petry, H.M., Green, P.T., Pidwell, D.J., and Seiler, M.J. (2008). Vision Improvement in Retinal Degeneration Patients by Implantation of Retina Together with Retinal Pigment Epithelium. Am. J. Ophthalmol. 146, 172–182.
Sato, S., Omori, Y., Katoh, K., Kondo, M., Kanagawa, M., Miyata, K., Funabiki, K., Koyasu, T., Kajimura, N., Miyoshi, T., et al. (2008). Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation. Nat. Neurosci. 11, 923–931.
Shirai, H., Mandai, M., Matsushita, K., Kuwahara, A., Yonemura, S., Nakano, T., Assawachananont, J., Kimura, T., Saito, K., Terasaki, H., et al. (2016). Transplantation of human embryonic stem cell- derived retinal tissue in two primate models of retinal degeneration. Proc. Natl. Acad. Sci. 113, E81–E90.
Streilein, J.W. (2003). Ocular immune privilege: Therapeutic opportunities from an experiment of nature. Nat. Rev. Immunol. 3, 879–889.
Sugita, S. (2009). Role of ocular pigment epithelial cells in immune privilege. Arch. Immunol. Ther. Exp. (Warsz). 57, 263–268.
Sugita, S., Futagami, Y., Smith, S.B., Naggar, H., and Mochizuki, M. (2006). Retinal and ciliary body pigment epithelium suppress activation of T lymphocytes via transforming growth factor beta. Exp. Eye Res. 83, 1459–1471.
Sugita, S., Iwasaki, Y., Makabe, K., Kamao, H., Mandai, M., Shiina, T., Ogasawara, K., Hirami, Y., Kurimoto, Y., and Takahashi, M. (2016a). Successful Transplantation of Retinal Pigment Epithelial Cells from MHC Homozygote iPSCs in MHC-Matched Models. Stem Cell Reports 7, 635–648.
Sugita, S., Iwasaki, Y., Makabe, K., Kimura, T., Futagami, T., Suegami, S., and Takahashi, M. (2016b). Lack of T Cell Response to iPSC-Derived Retinal Pigment Epithelial Cells from HLA Homozygous Donors. Stem Cell Reports 7, 619–634.
Sugita, S., Iwasaki, Y., Makabe, K., Kamao, H., Mandai, M., Shiina, T., Ogasawara, K., Hirami, Y., Kurimoto, Y., and Takahashi, M. (2016c). Successful Transplantation of Retinal Pigment Epithelial Cells from MHC Homozygote iPSCs in MHC-Matched Models. Stem Cell Reports 7, 635–648.
Sugita, S., Mandai, M., Hirami, Y., Takagi, S., Maeda, T., Fujihara, M., Matsuzaki, M., Yamamoto, M., Iseki, K., Hayashi, N., et al. (2020). HLA-Matched Allogeneic iPS Cells-Derived RPE Transplantation for Macular Degeneration. J. Clin. Med. 9, 2217 1-18.
Takahashi, K., and Yamanaka, S. (2006). Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors. Cell 126, 663–676.
Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., and Yamanaka, S. (2007). Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors. Cell 131, 861–872.
Thomson, J.A. (1998). Embryonic stem cell lines derived from human blastocysts. Science (80-. ). 282, 1145–1147.
Tu, H.Y., Watanabe, T., Shirai, H., Yamasaki, S., Kinoshita, M., Matsushita, K., Hashiguchi, T., Onoe, H., Matsuyama, T., Kuwahara, A., et al. (2019). Medium- to long-term survival and functional examination of human iPSC-derived retinas in rat and primate models of retinal degeneration. EBioMedicine 39, 562–574.
Watanabe, K., Ueno, M., Kamiya, D., Nishiyama, A., Matsumura, M., Wataya, T., Takahashi, J.B., Nishikawa, S., Nishikawa, S.I., Muguruma, K., et al. (2007). A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat. Biotechnol. 25, 681–686.
Wooff, Y., Man, S.M., Aggio-Bruce, R., Natoli, R., and Fernando, N. (2019). IL-1 family members mediate cell death, inflammation and angiogenesis in retinal degenerative diseases. Front. Immunol. 10, 1–21.
Yamasaki, S., Sugita, S., Horiuchi, M., Masuda, T., Fujii, S., Makabe, K., Kawasaki, A., Hayashi, T., Kuwahara, A., Kishino, A., et al. (2021). Low Immunogenicity and Immunosuppressive Properties of Human ESC- and iPSC-Derived Retinas. Stem Cell Reports 16, 851–867.
Yamasaki, S., Tu, H.-Y., Matsuyama, T., Horiuchi, M., Hashiguchi, T., Sho, J., Kuwahara, A., Kishino, A., Kimura, T., Takahashi, M., et al. (2022). A Genetic modification that reduces ON-bipolar cells in hESC-derived retinas enhances functional integration after transplantation cells in hESC- derived retinas enhances. IScience 25, 103657.
Yau, K.W., and Hardie, R.C. (2009). Phototransduction Motifs and Variations. Cell 139, 246–264.
論文の公開元へ
