Abe K, Shimada R, Okada Y, Kibayashi K. 2016. Traumatic brain injury decreases serotonin
transporter expression in the rat cerebrum. Neurol Res 38:358–363.
Abrahamson EE, Moore RY. 2001. Suprachiasmatic nucleus in the mouse: Retinal
innervation, intrinsic organization and efferent projections. Brain Res 916:172–191.
Acosta-Galvan G, Yi C-X, van der Vliet J, Jhamandas JH, Panula P, Angeles-Castellanos M,
del Carmen Basualdo M, Escobar C, Buijs RM. 2011. Interaction between hypothalamic
dorsomedial nucleus and the suprachiasmatic nucleus determines intensity of food
anticipatory behavior. Proc Natl Acad Sci 108:5813–5818.
Aggleton JP, Brown MW. 1999. Episodic memory, amnesia, and the hippocampal-anterior
thalamic axis. Behav Brain Sci 22:425–44; discussion 444-89.
Allen Institute for Brain Science. 2004. Allen Mouse Brain Atlas. Available from:
http://atlas.brain-map.org/
Altman J, Bayer SA. 1986. The development of the rat hypothalamus. Adv Anat Embryol
Cell Biol 100:1–178.
Amano T, Duvarci S, Popa D, Pare D. 2011. The Fear Circuit Revisited: Contributions of the
Basal Amygdala Nuclei to Conditioned Fear. J Neurosci 31:15481–15489.
Anon. 2020. serotonin. Available from:
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28790
Asan E, Steinke M, Lesch KP. 2013. Serotonergic innervation of the amygdala: Targets,
receptors, and implications for stress and anxiety. Histochem Cell Biol 139:785–813.
Audet MA, Descarries L, Doucet G. 1989. Quantified regional and laminar distribution of the
serotonin innervation in the anterior half of adult rat cerebral cortex. J Chem Neuroanat
2:29–44.
Azmitia E, Gannon P. 1983. The ultrastructural localization of serotonin immunoreactivity in
myelinated and unmyelinated axons within the medial forebrain bundle of rat and
monkey. J Neurosci 3:2083–90.
Azmitia EC, Singh JS, Whitaker-Azmitia PM. 2011. Increased serotonin axons
(immunoreactive to 5-HT transporter) in postmortem brains from young autism donors.
Neuropharmacology 60:1347–1354.
Baker KG, Halliday GM, Halasz P, Hornung J -P, Geffen LB, Cotton RGH, Törk I. 1991.
Cytoarchitecture of serotonin-synthesizing neurons in the pontine tegmentum of the
human brain. Synapse 7:301–320.
Beal MF, Martin JB. 1985. Topographical dopamine and serotonin distribution and turnover
in rat striatum. Brain Res 358:10–15.
Beaudet A, Descarries L. 1979. Radioautographic characterization of a serotoninaccumulating nerve cell group in adult rat hypothalamus. Brain Res 160:231–243.
Belmer A, Klenowski PM, Patkar OL, Bartlett SE. 2017. Mapping the connectivity of
serotonin transporter immunoreactive axons to excitatory and inhibitory neurochemical
synapses in the mouse limbic brain. Brain Struct Funct 222:1297–1314.
Berger M, Gray JA, Roth BL. 2009. The Expanded Biology of Serotonin. Annu Rev Med
60:355–366.
73
Van Bockstaele EJ, Biswas A, Pickel VM. 1993. Topography of serotonin neurons in the
dorsal raphe nucleus that send axon collaterals to the rat prefrontal cortex and nucleus
accumbens. Brain Res 624:188–98.
Bonn M, Schmitt A, Lesch K-P, Van Bockstaele EJ, Asan E. 2013. Serotonergic innervation
and serotonin receptor expression of NPY-producing neurons in the rat lateral and
basolateral amygdaloid nuclei. Brain Struct Funct 218:421–435.
Bonnin A, Levitt P. 2011. Fetal, maternal, and placental sources of serotonin and new
implications for developmental programming of the brain. Neuroscience 197:1–7.
Borgers AJ, Koopman KE, Bisschop PH, Serlie MJ, Swaab DF, Fliers E, la Fleur SE,
Alkemade A. 2014. Decreased serotonin transporter immunoreactivity in the human
hypothalamic infundibular nucleus of overweight subjects. Front Neurosci 8.
Borue X, Chen J, Condron BG. 2007. Developmental effects of SSRIs: lessons learned from
animal studies. Int J Dev Neurosci 25:341–347.
Botchkina GI, Morin LP. 1993. Development of the hamster serotoninergic system: Cell
groups and diencephalic projections. J Comp Neurol 338:405–431.
Bradbury MJ, Dement WC, Edgar DM. 1997. Serotonin-containing fibers in the
suprachiasmatic hypothalamus attenuate light-induced phase delays in mice. Brain Res
768:125–34.
Brivio P, Homberg JR, Riva MA, Calabrese F. 2019. Alterations of Glutamatergic Markers in
the Prefrontal Cortex of Serotonin Transporter Knockout Rats: A Developmental
Timeline. Cell Mol Neurobiol 39:715–720.
Calas A, Alonso G, Arnauld E, Vincent JD. 1974. Demonstration of indolaminergic fibres in
the median eminence of the duck, rat and monkey. Nature 250:241–243.
Calizo LH, Akanwa A, Ma X, Pan YZ, Lemos JC, Craige C, Heemstra LA, Beck SG. 2011.
Raphe serotonin neurons are not homogenous: Electrophysiological, morphological and
neurochemical evidence. Neuropharmacology 61:524–543.
Carmona-Alcocer V, Abel JH, Sun TC, Petzold LR, Doyle FJ, Simms CL, Herzog ED. 2018.
Ontogeny of circadian rhythms and synchrony in the suprachiasmatic nucleus. J
Neurosci 38:1326–1334.
Cavaccini A, Gritti M, Giorgi A, Locarno A, Heck N, Migliarini S, Bertero A, Mereu M,
Margiani G, Trusel M, Catelani T, Marotta R, De Luca MA, Caboche J, Gozzi A,
Pasqualetti M, Tonini R. 2018. Serotonergic Signaling Controls Input-Specific Synaptic
Plasticity at Striatal Circuits. Neuron 98:801-816.e7.
Chen JJ, Li Z, Pan H, Murphy DL, Tamir H, Koepsell H, Gershon MD. 2001. Maintenance of
Serotonin in the Intestinal Mucosa and Ganglia of Mice that Lack the High-Affinity
Serotonin Transporter: Abnormal Intestinal Motility and the Expression of Cation
Transporters. J Neurosci 21:6348–6361.
Chen X, Ye R, Gargus JJ, Blakely RD, Dobrenis K, Sze JY. 2015. Disruption of Transient
Serotonin Accumulation by Non-Serotonin-Producing Neurons Impairs Cortical Map
Development. Cell Rep 10:346–358.
Ciarleglio CM, Resuehr HES, McMahon DG. 2011. Interactions of the serotonin and
circadian systems: Nature and nurture in rhythms and blues. Neuroscience 197:8–16.
Clark CT, Weissbach H, Udenfriend S. 1954. 5-Hydroxytryptophan decarboxylase:
preparation and properties. J Biol Chem 210:139–148.
74
Coleman JA, Green EM, Gouaux E. 2016. X-ray structures and mechanism of the human
serotonin transporter. Nature 532:334–339.
Conrad LCA, Leonard CM, Pfaff DW. 1974. Connections of the median and dorsal raphe
nuclei in the rat: An autoradiographic and degeneration study. J Comp Neurol 156:179–
205.
Cordes SP. 2005. Molecular genetics of the early development of hindbrain serotonergic
neurons. Clin Genet 68:487–494.
Courchesne E. 1997. Brainstem, cerebellar and limbic neuroanatomical abnormalities in
autism. Curr Opin Neurobiol 7:269–78.
Cropper EC, Eisenman JS, Azmitia EC. 1984. An immunocytochemical study of the
serotonergic innervation of the thalamus of the rat. J Comp Neurol 224:38–50.
D. G. Stuart. 1962. Anatomy of the Hypothalamus-and Its Connections (AAL-TDR-62-13
407 ’ 091). Los Angeles.
Dahlström A, Fuxe K. 1964. Localization of monoamines in the lower brain stem.
Experientia 20:398–9.
Deneris E, Gaspar P. 2018. Serotonin neuron development: shaping molecular and structural
identities. Wiley Interdiscip Rev Dev Biol 7.
Descarries L, Cornea-Hébert V, Riad M. 2006. Cellular and Subcellular Localization of
Serotonin Receptors in the Central Nervous System. In: The Serotonin Receptors.
Humana Press. p 277–317.
Descarries L, Mechawar N. 2000. Ultrastructural evidence for diffuse transmission by
monoamine and acetylcholine neurons of the central nervous system. In: Progress in
Brain Research. Vol. 125. Elsevier. p 27–47.
Dewar KM, Reader TA, Grondin L, Descarries L. 1991. [3H]Paroxetine binding and
serotonin content of rat and rabbit cortical areas, hippocampus, neostriatum, ventral
mesencephalic tegmentum, and midbrain raphe nuclei region. Synapse 9:14–26.
Dudley TE, DiNardo LA, Glass JD. 1998. Endogenous regulation of serotonin release in the
hamster suprachiasmatic nucleus. J Neurosci 18:5045–52.
Eid L, Champigny M-F, Parent A, Parent M. 2013. Quantitative and ultrastructural study of
serotonin innervation of the globus pallidus in squirrel monkeys. Eur J Neurosci
37:1659–1668.
Erspamer V, Asero B. 1952. Identification of Enteramine, the Specific Hormone of the
Enterochromaffin Cell System, as 5-Hydroxytryptamine. Nature 169:800–801.
Ferguson JN, Aldag JM, Insel TR, Young LJ. 2001. Oxytocin in the medial amygdala is
essential for social recognition in the mouse. J Neurosci 21:8278–85.
Fetissov S., Meguid M., Chen C, Miyata G. 2000. Synchronized release of dopamine and
serotonin in the medial and lateral hypothalamus of rats. Neuroscience 101:657–663.
Forcelli PA, Heinrichs SC. 2008. Teratogenic effects of maternal antidepressant exposure on
neural substrates of drug-seeking behavior in offspring. Addict Biol 13:52–62.
Fox MA, Andrews AM, Wendland JR, Lesch K-P, Holmes A, Murphy DL. 2007. A
pharmacological analysis of mice with a targeted disruption of the serotonin transporter.
Psychopharmacology (Berl) 195:147–166.
75
Frazer A, Hensler J. 1999. Basic Neurochemistry: Molecular, Cellular and Medical Aspects.
In: iegel GJ, Agranoff BW AR, editor. 6th ed. Philadelphia: Lippincott-Raven.
Fu W, Le Maître E, Fabre V, Bernard JF, Xu ZQD, Hökfelt T. 2010. Chemical neuroanatomy
of the dorsal raphe nucleus and adjacent structures of the mouse brain. J Comp Neurol
518:3464–3494.
Fuxe K. 1965. Evidence for the existence of monoamine neurons in the central nervous
system. Iv. Distribution of monoamine nerve terminals in the central nervous system.
Acta Physiol Scand Suppl:SUPPL 247:37+.
Fuxe K, Jonsson G. 1967. A modification of the histochemical fluorescence method for the
improved localization of 5-hydroxytryptamine. Histochemie 11:161–166.
Fuxe K, Jonsson G. 1974. Further mapping of central 5-hydroxytryptamine neurons: studies
with the neurotoxic dihydroxytryptamines. Adv Biochem Psychopharmacol 10:1–12.
Gagnon D, Parent M. 2014. Distribution of VGLUT3 in highly collateralized axons from the
rat dorsal raphe nucleus as revealed by single-neuron reconstructions. PLoS One
9:e87709.
Gaspar P, Cases O, Maroteaux L. 2003. The developmental role of serotonin: News from
mouse molecular genetics. Nat Rev Neurosci 4:1002–1012.
Gong S, Zheng C, Doughty ML, Losos K, Didkovsky N, Schambra UB, Nowak NJ, Joyner
A, Leblanc G, Hatten ME, Heintz N. 2003. A gene expression atlas of the central
nervous system based on bacterial artificial chromosomes. Nature 425:917–925.
Gonzalo-Ruiz A, Lieberman A., Sanz-Anquela J. 1995. Organization of serotoninergic
projections from the raphé nuclei to the anterior thalamic nuclei in the rat: a combined
retrograde tracing and 5-HT immunohistochemical study. J Chem Neuroanat 8:103–115.
Gras C, Herzog E, Bellenchi GC, Bernard V, Ravassard P, Pohl M, Gasnier B, Giros B, El
Mestikawy S. 2002. A third vesicular glutamate transporter expressed by cholinergic
and serotoninergic neurons. J Neurosci 22:5442–5451.
De Gregorio R, Chen X, Petit EI, Dobrenis K, Sze JY. 2020. Disruption of Transient SERT
Expression in Thalamic Glutamatergic Neurons Alters Trajectory of Postnatal
Interneuron Development in the Mouse Cortex. Cereb Cortex 30:1623–1636.
Groenewegen HJ, Witter MP. 2004. Thalamus. Rat Nerv Syst:407–453.
Gu Q, Patel B, Singer W. 1990. The laminar distribution and postnatal development of
serotonin-immunoreactive axons in the cat primary visual cortex. Exp brain Res 81:257–
66.
Haney EM, Calarge C, Bliziotes MM. 2013. Clinical Implications of Serotonin Regulation of
Bone Mass. In: Translational Endocrinology of Bone. Elsevier. p 189–198.
Hansson SR, Mezey É, Hoffman BJ. 1998. Serotonin transporter messenger RNA in the
developing rat brain: Early expression in serotonergic neurons and transient expression
in non- serotonergic neurons. Neuroscience 83:1185–1201.
Hansson SR, Mezey É, Hoffman BJ. 1999. Serotonin transporter messenger RNA expression
in neural crest-derived structures and sensory pathways of the developing rat embryo.
Neuroscience 89:243–265.
Harrington B. 2005. Draw Freely | Inkscape. Available from: https://inkscape.org/
Hawthorne AL, Hu H, Kundu B, Steinmetz MP, Wylie CJ, Deneris ES, Silver J. 2011. The
76
unusual response of serotonergic neurons after CNS injury: Lack of axonal dieback and
enhanced sprouting within the inhibitory environment of the glial scar. J Neurosci
31:5605–5616.
Hong S, Hikosaka O. 2008. The Globus Pallidus Sends Reward-Related Signals to the Lateral
Habenula. Neuron 60:720–729.
Van den Hove D, Jakob SB, Schraut K-G, Kenis G, Schmitt AG, Kneitz S, Scholz C-J,
Wiescholleck V, Ortega G, Prickaerts J, Steinbusch H, Lesch K-P. 2011. Differential
Effects of Prenatal Stress in 5-Htt Deficient Mice: Towards Molecular Mechanisms of
Gene × Environment Interactions. PLoS One 6:e22715.
Hrovatin K, Kunej T, Dolžan V. 2019. Genetic variability of serotonin pathway associated
with schizophrenia onset, progression, and treatment. Am J Med Genet Part B
Neuropsychiatr Genet.
Ishimura K, Takeuchi Y, Fujiwara K, Tominaga M, Yoshioka H, Sawada T. 1988.
Quantitative analysis of the distribution of serotonin-immunoreactive cell bodies in the
mouse brain. Neurosci Lett 91:265–70.
Jafari G, Xie Y, Kullyev A, Liang B, Sze JY. 2011. Regulation of extrasynaptic 5-HT by
serotonin reuptake transporter function in 5-HT-absorbing neurons underscores
adaptation behavior in Caenorhabditis elegans. J Neurosci 31:8948–8957.
Jensen P, Farago AF, Awatramani RB, Scott MM, Deneris ES, Dymecki SM. 2008.
Redefining the serotonergic system by genetic lineage. Nat Neurosci 11:417–419.
Johnson MD, Yee AG. 1995. Ultrastructure of electrophysiologically-characterized synapses
formed by serotonergic raphe neurons in culture. Neuroscience 67:609–23.
Johnson PL, Molosh A, Fitz SD, Arendt D, Deehan GA, Federici LM, Bernabe C, Engleman
EA, Rodd ZA, Lowry CA, Shekhar A. 2015. Pharmacological depletion of serotonin in
the basolateral amygdala complex reduces anxiety and disrupts fear conditioning.
Pharmacol Biochem Behav 138:174–179.
Johnson PL, Molosh AI, Federici LM, Bernabe C, Haggerty D, Fitz SD, Nalivaiko E, Truitt
W, Shekhar A. 2019. Assessment of fear and anxiety associated behaviors, physiology
and neural circuits in rats with reduced serotonin transporter (SERT) levels. Transl
Psychiatry 9:33.
Kalueff AV, Olivier JDA, Nonkes LJP, Homberg JR. 2010. Conserved role for the serotonin
transporter gene in rat and mouse neurobehavioral endophenotypes. Neurosci Biobehav
Rev 34:373–386.
Kannan S, Saadani-Makki F, Balakrishnan B, Dai H, Chakraborty PK, Janisse J, Muzik O,
Romero R, Chugani DC. 2011. Decreased Cortical Serotonin in Neonatal Rabbits
Exposed to Endotoxin in Utero. J Cereb Blood Flow Metab 31:738–749.
Kish SJ, Tong J, Hornykiewicz O, Rajput A, Chang L-J, Guttman M, Furukawa Y. 2007.
Preferential loss of serotonin markers in caudate versus putamen in Parkinson’s disease.
Brain 131:120–31.
Köhler C, Chan-Palay V, Steinbusch H. 1982. The distribution and origin of serotonincontaining fibers in the septal area: A combined immunohistochemical and fluorescent
retrograde tracing study in the rat. J Comp Neurol 209:91–111.
Van der Kooy D, Hattori T. 1980. Dorsal raphe cells with collateral projections to the
caudate-putamen and substantia nigra: A fluorescent retrograde double labeling study in
77
the rat. Brain Res 186:1–7.
Kosofsky BE, Molliver ME. 1987. The serotoninergic innervation of cerebral cortex:
Different classes of axon terminals arise from dorsal and median raphe nuclei. Synapse
1:153–168.
Kuramochi M, Nakamura S. 2009. Effects of postnatal isolation rearing and antidepressant
treatment on the density of serotonergic and noradrenergic axons and depressive
behavior in rats. Neuroscience 163:448–455.
Kuzelova H, Ptacek R, Macek M. 2010. The serotonin transporter gene (5-HTT) variant and
psychiatric disorders: review of current literature. Neuro Endocrinol Lett 31:4–10.
Lam DD, Garfield AS, Marston OJ, Shaw J, Heisler LK. 2010. Brain serotonin system in the
coordination of food intake and body weight. Pharmacol Biochem Behav 97:84–91.
Lauder JM, Wallace JA, Krebs H. 1981. Roles for serotonin in neuroembryogenesis. Adv
Exp Med Biol 133:477–506.
Lavoie B, Parent A. 1991. Serotoninergic innervation of the thalamus in the primate: An
immunohistochemical study. J Comp Neurol 312:1–18.
Lebrand C, Cases O, Adelbrecht C, Doye A, Alvarez C, El Mestikawy S, Seif I, Gaspar P.
1996. Transient uptake and storage of serotonin in developing thalamic neurons. Neuron
17:823–835.
Lebrand C, Cases O, Wehrlé R, Blakely RD, Edwards RH, Gaspar P. 1998. Transient
developmental expression of monoamine transporters in the rodent forebrain. J Comp
Neurol 401:506–524.
Lee J-H, Kim HJ, Kim JG, Ryu V, Kim B-T, Kang D-W, Jahng JW. 2007. Depressive
behaviors and decreased expression of serotonin reuptake transporter in rats that
experienced neonatal maternal separation. Neurosci Res 58:32–39.
Legutko R, Gannon RL. 2001. Serotonin transporter localization in the hamster
suprachiasmatic nucleus. Brain Res 893:77–83.
Li Q. 2006. Cellular and molecular alterations in mice with deficient and reduced serotonin
transporters. Mol Neurobiol 34:51–65.
Lidov HGW, Grzanna R, Molliver ME. 1980. The serotonin innervation of the cerebral
cortex in the rat-an immunohistochemical analysis. Neuroscience 5:207–227.
Lidov HGW, Molliver ME. 1982. An immunohistochemical study of serotonin neuron
development in the rat: Ascending pathways and terminal fields. Brain Res Bull 8:389–
430.
Lin SH, Lee LT, Yang YK. 2014. Serotonin and mental disorders: A concise review on
molecular neuroimaging evidence. Clin Psychopharmacol Neurosci 12:196–202.
Lindvall O, Bjorklund A. 1974. The organization of the ascending catecholamine neuron
systems in the rat brain as revealed by the glyoxylic acid fluorescence method. Acta
Physiol Scand 412:1–48.
Luellen BA, Gilman TL, Andrews AM. 2010. Presynaptic adaptive responses to constitutive
versus adult pharmacologic inhibition of serotonin uptake. In: Kalueff A V., LaPorte JL,
editors. Experimental Models in Serotonin Transporter Research. Cambridge:
Cambridge University Press. p 1–42.
Lumsden A, Krumlauf R. 1996. Patterning the vertebrate neuraxis. Science (80- ) 274:1109–
78
1115.
Maciag D, Simpson KL, Coppinger D, Lu Y, Wang Y, Lin RCS, Paul IA. 2006. Neonatal
antidepressant exposure has lasting effects on behavior and serotonin circuitry.
Neuropsychopharmacology 31:47–57.
Maddaloni G, Bertero A, Pratelli M, Barsotti N, Boonstra A, Giorgi A, Migliarini S,
Pasqualetti M. 2017. Development of serotonergic fibers in the post-natal mouse brain.
Front Cell Neurosci 11:202.
Maia GH, Soares JI, Almeida SG, Leite JM, Baptista HX, Lukoyanova AN, Brazete CS,
Lukoyanov N V. 2019. Altered serotonin innervation in the rat epileptic brain. Brain Res
Bull 152:95–106.
Makkonen I, Riikonen R, Kokki H, Airaksinen MM, Kuikka JT. 2008. Serotonin and
dopamine transporter binding in children with autism determined by SPECT. Dev Med
Child Neurol 50:593–597.
Marco EM, Velarde E, Llorente R, Laviola G. 2016. Disrupted circadian rhythm as a
common player in developmental models of neuropsychiatric disorders. In: Current
Topics in Behavioral Neurosciences. Vol. 29. Springer Verlag. p 155–181.
McDonald AJ. 1998. Cortical pathways to the mammalian amygdala. Prog Neurobiol
55:257–332.
Meyer-Bernstein EL, Morin LP. 1996. Differential serotonergic innervation of the
suprachiasmatic nucleus and the intergeniculate leaflet and its role in circadian rhythm
modulation. J Neurosci 16:2097–111.
Migliarini S, Pacini G, Pelosi B, Lunardi G, Pasqualetti M. 2013. Lack of brain serotonin
affects postnatal development and serotonergic neuronal circuitry formation. Mol
Psychiatry 18:1106–1118.
Miller JJ, Richardson TL, Fibiger HC, McLennan H. 1975. Anatomical and
electrophysiological identification of a projection from the mesencephalic raphe to the
caudate-putamen in the rat. Brain Res 97:133–138.
Miner LH, Schroeter S, Blakely RD, Sesack SR. 2000. Ultrastructural localization of the
serotonin transporter in superficial and deep layers of the rat prelimbic prefrontal cortex
and its spatial relationship to dopamine terminals. J Comp Neurol 427:220–34.
Mirochnik V, Bosler O, Tillet Y, Calas A, Ugrumov M. 2005. Long-lasting effects of
serotonin deficiency on differentiating peptidergic neurons in the rat suprachiasmatic
nucleus. Int J Dev Neurosci 23:85–91.
Mizumori SJY, Miya DY, Ward KE. 1994. Reversible inactivation of the lateral dorsal
thalamus disrupts hippocampal place representation and impairs spatial learning. Brain
Res 644:168–174.
Mohammad-Zadeh LF, Moses L, Gwaltney-Brant SM. 2008. Serotonin: A review. J Vet
Pharmacol Ther 31:187–199.
Mori S, Ueda S, Yamada H, Takino T, Sano Y. 1985. Immunohistochemical demonstration
of serotonin nerve fibers in the corpus striatum of the rat, cat and monkey. Anat
Embryol (Berl) 173:1–5.
Morin L., Meyer-Bernstein E. 1999. The ascending serotonergic system in the hamster:
comparison with projections of the dorsal and median raphe nuclei. Neuroscience
91:81–105.
79
Morin LP. 2007. SCN organization reconsidered. J Biol Rhythms 22:3–13.
Morrison JH, Foote SL, Molliver ME, Bloom FE, Lidov HG. 1982. Noradrenergic and
serotonergic fibers innervate complementary layers in monkey primary visual cortex: an
immunohistochemical study. Proc Natl Acad Sci 79:2401–2405.
Muller JF, Mascagni F, McDonald AJ. 2007. Serotonin-immunoreactive axon terminals
innervate pyramidal cells and interneurons in the rat basolateral amygdala. J Comp
Neurol 505:314–335.
Murphy DL, Lesch KP. 2008. Targeting the murine serotonin transporter: Insights into
human neurobiology. Nat Rev Neurosci 9:85–96.
Muzerelle A, Scotto-Lomassese S, Bernard JF, Soiza-Reilly M, Gaspar P. 2016. Conditional
anterograde tracing reveals distinct targeting of individual serotonin cell groups (B5–B9)
to the forebrain and brainstem. Brain Struct Funct 221:535–561.
Nakamura K, Sekine Y, Ouchi Y, Tsujii M, Yoshikawa E, Futatsubashi M, Tsuchiya KJ,
Sugihara G, Iwata Y, Suzuki K, Matsuzaki H, Suda S, Sugiyama T, Takei N, Mori N.
2010. Brain Serotonin and Dopamine Transporter Bindings in Adults With HighFunctioning Autism. Arch Gen Psychiatry 67:59.
Narboux-Nême N, Pavone LM, Avallone L, Zhuang X, Gaspar P. 2008. Serotonin transporter
transgenic (SERTcre) mouse line reveals developmental targets of serotonin specific
reuptake inhibitors (SSRIs). Neuropharmacology 55:994–1005.
Nielsen K, Brask D, Knudsen GM, Aznar S. 2006. Immunodetection of the serotonin
transporter protein is a more valid marker for serotonergic fibers than serotonin. Synapse
59:270–276.
Nishimura A, Ueda S, Takeuchi Y, Matsushita H, Sawada T, Kawata M. 1998. Vulnerability
to aging in the rat serotonergic system. Acta Neuropathol 96:581–595.
O’Hearn E, Battaglia G, De Souza EB, Kuhar MJ, Molliver ME. 1988.
Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA)
cause selective ablation of serotonergic axon terminals in forebrain:
immunocytochemical evidence for neurotoxicity. J Neurosci 8:2788–803.
O’Rourke H, Fudge JL. 2006. Distribution of Serotonin Transporter Labeled Fibers in
Amygdaloid Subregions: Implications for Mood Disorders. Biol Psychiatry 60:479–490.
Okaty BW, Commons KG, Dymecki SM. 2019. Embracing diversity in the 5-HT neuronal
system. Nat Rev Neurosci 20:397–424.
Okaty BW, Freret ME, Rood BD, Brust RD, Hennessy ML, deBairos D, Kim JC, Cook MN,
Dymecki SM. 2015. Multi-Scale Molecular Deconstruction of the Serotonin Neuron
System. Neuron 88:774–791.
Parent A, Descarries L, Beaudet A. 1981. Organization of ascending serotonin systems in the
adult rat brain. A radioautographic study after intraventricular administration of [3h]5hydroxytryptamine. Neuroscience 6:115–138.
Pelosi B, Migliarini S, Pacini G, Pratelli M, Pasqualetti M. 2014. Generation of Pet1210-Cre
Transgenic Mouse Line Reveals Non-Serotonergic Expression Domains of Pet1 Both in
CNS and Periphery. PLoS One 9:e104318.
Persico AM, Altamura C, Calia E, Puglisi-Allegra S, Ventura R, Lucchese F, Keller F. 2000.
Serotonin Depletion and Barrel Cortex Development: Impact of Growth Impairment vs.
Serotonin Effects on Thalamocortical Endings. Cereb Cortex 10:181–191.
80
Petrov T, Krukoff TL, Jhamandas JH. 1994. Chemically defined collateral projections from
the pons to the central nucleus of the amygdala and hypothalamic paraventricular
nucleus in the rat. Cell Tissue Res 277:289–95.
Pickel VM, Joh TH, Reis DJ. 1977. A serotonergic innervation of noradrenergic neurons in
nucleus locus coeruleus: demonstration by immunocytochemical localization of the
transmitter specific enzymes tyrosine and tryptophan hydroxylase. Brain Res 131:197–
214.
Pollak Dorocic I, Fürth D, Xuan Y, Johansson Y, Pozzi L, Silberberg G, Carlén M, Meletis
K. 2014. A Whole-Brain Atlas of Inputs to Serotonergic Neurons of the Dorsal and
Median Raphe Nuclei. Neuron 83:663–678.
Pontes ALB de, Engelberth RCGJ, Nascimento E da S, Cavalcante JC, Costa MSM de O,
Pinato L, Toledo CAB de, Cavalcante J de S. 2010. Serotonin and circadian rhythms.
Psychol Neurosci 3:217–228.
Rajkowska G, Mahajan G, Legutko B, Challagundla L, Griswold M, Albert PR, Daigle M,
Miguel-Hidalgo JJ, Austin MC, Blakely RD, Steffens DC, Stockmeier CA. 2017.
Length of axons expressing the serotonin transporter in orbitofrontal cortex is lower with
age in depression. Neuroscience 359:30–39.
Rapport MM, Green AA, Page IH. 1948a. Crystalline Serotonin. Science 108:329–30.
Rapport MM, Green AA, Page IH. 1948b. Serum vasoconstrictor, serotonin; isolation and
characterization. J Biol Chem 176:1243–51.
Rasband W. 1997. ImageJ. U S Natl Institutes Heal Bethesda, Maryland, USA, [Internet].
Available from: https://imagej.nih.gov/ij/
Rebello TJ, Yu Q, Caffrey Cagliostro MK, Teissier A, Morelli E, Demireva EY, Chemiakine
A, Rosoklija GB, Dwork AJ, Gingrich JA, Ansorge MS, Goodfellow NM, Lambe EK,
Rosoklija GB, Dwork AJ, Gingrich JA, Ansorge MS, Rosoklija GB, Dwork AJ. 2014.
Postnatal day 2 to 11 constitutes a 5-HT-sensitive period impacting adult mPFC
function. J Neurosci 34:12379–12393.
Reinebrant H, Wixey J, Buller K. 2020. Hypoxia-ischemia in the immature rodent brain
impairs serotonergic neuronal function in certain dorsal raphé nuclei. Neural Regen Res
15:457–463.
Ren J, Friedmann D, Xiong J, Liu CD, Ferguson BR, Weerakkody T, DeLoach KE, Ran C,
Pun A, Sun Y, Weissbourd B, Neve RL, Huguenard J, Horowitz MA, Luo L. 2018.
Anatomically Defined and Functionally Distinct Dorsal Raphe Serotonin Sub-systems.
Cell 175:472-487.e20.
Ren J, Isakova A, Friedmann D, Zeng J, Grutzner SM, Pun A, Zhao GQ, Kolluru SS, Wang
R, Lin R, Li P, Li A, Raymond JL, Luo Q, Luo M, Quake SR, Luo L. 2019. Single-cell
transcriptomes and whole-brain projections of serotonin neurons in the mouse dorsal and
median raphe nuclei. Elife 8.
Richards JG, Da Prada M, Würsch J, Lorez HP, Pieri L. 1979. Mapping monoaminergic
neurons with [3H]reserpine by autoradiography. Neuroscience 4:937–950.
Risold PY. 2004. The Septal Region. In: The Rat Nervous System. Elsevier Inc. p 605–632.
Rodríguez JJ, Noristani HN, Hoover WB, Linley SB, Vertes RP. 2011. Serotonergic
projections and serotonin receptor expression in the reticular nucleus of the thalamus in
the rat. Synapse 65:919–928.
81
Rubenstein JLR. 1998. Development of serotonergic neurons and their projections. Biol
Psychiatry 44:145–150.
Schmidt EF, Kus L, Gong S, Heintz N. 2013. BAC Transgenic Mice and the GENSAT
Database of Engineered Mouse Strains.
Serretti A, Calati R, Mandelli L, De Ronchi D. 2006. Serotonin Transporter Gene Variants
and Behavior: A Comprehensive Review. Curr Drug Targets 7:1659–1669.
Shikanai H, Yoshida T, Konno K, Yamasaki M, Izumi T, Ohmura Y, Watanabe M, Yoshioka
M. 2012. Distinct neurochemical and functional properties of GAD67-containing 5-HT
neurons in the rat dorsal raphe nucleus. J Neurosci 32:14415–14426.
Sidor MM, Amath A, MacQueen G, Foster JA. 2010. A developmental characterization of
mesolimbocortical serotonergic gene expression changes following early immune
challenge. Neuroscience 171:734–746.
Slotkin TA, Barnes GA, McCook EC, Seidler FJ. 1996. Programming of brainstem serotonin
transporter development by prenatal glucocorticoids. Dev Brain Res 93:155–161.
Sourani D, Eitan R, Gordon N, Goelman G. 2012. The habenula couples the dopaminergic
and the serotonergic systems: application to depression in Parkinson’s disease. Eur J
Neurosci 36:2822–2829.
Steinbusch HW. 1981. Distribution of serotonin-immunoreactivity in the central nervous
system of the rat-cell bodies and terminals. Neuroscience 6:557–618.
Storvik M, Haukijarvi T, Tupala E, Tiihonen J. 2007a. Correlation between the SERT
binding densities in hypothalamus and amygdala in cloninger type 1 and 2 alcoholics.
Alcohol Alcohol 43:25–30.
Storvik M, Tiihonen J, Haukijärvi T, Tupala E. 2007b. Amygdala serotonin transporters in
alcoholics measured by whole hemisphere autoradiography. Synapse 61:629–636.
Su H-S, Bentivoglio M. 1990. Thalamic midline cell populations projecting to the nucleus
accumbens, amygdala, and hippocampus in the rat. J Comp Neurol 297:582–593.
Sur C, Betz H, Schloss P. 1996. Immunocytochemical detection of the serotonin transporter
in rat brain. Neuroscience 73:217–31.
Takumi T, Tamada K, Hatanaka F, Nakai N, Bolton PF. 2019. Behavioral neuroscience of
autism. Neurosci Biobehav Rev 110:60–76.
Tamada K, Takumi T. 2015. Serotonin disturbance in mouse models of autism spectrum
disorders. In: Organism Models of Autism Spectrum Disorders. Springer New York. p
239–262.
Tanaka M, Sato A, Kasai S, Hagino Y, Kotajima-Murakami H, Kashii H, Takamatsu Y,
Nishito Y, Inagaki M, Mizuguchi M, Hall FS, Uhl GR, Murphy D, Sora I, Ikeda K.
2018. Brain hyperserotonemia causes autism-relevant social deficits in mice. Mol
Autism 9:60.
Ternaux JP, Héry F, Bourgoin S, Adrien J, Glowinski J, Hamon M. 1977. The topographical
distribution of serotoninergic terminals in the neostriatum of the rat and the caudate
nucleus of the cat. Brain Res 121:311–326.
Twarog BM, Page IH. 1953. Serotonin Content of Some Mammalian Tissues and Urine and a
Method for It ...