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Imaging of glucose metabolism by 13C-MRI distinguishes pancreatic cancer subtypes in mice

Kishimoto, Shun 京都大学 DOI:10.14989/doctor.r13489

2022.05.23

概要

Metabolic differences among and within tumors can be an important determinant incancer treatment outcome. However, methods for determining these differences non-invasively invivo is lacking. Using pancreatic ductal adenocarcinoma as a model, we demonstrate that tumorxenografts with a similar genetic background can be distinguished by their differing rates of themetabolism of 13C labeled glucose tracers, which can be imaged without hyperpolarization byusing newly developed techniques for noise suppression. Using this method, cancer subtypes thatappeared to have similar metabolic profiles based on steady state metabolic measurement can bedistinguished from each other. The metabolic maps from 13C-glucose imaging localized lactateproduction and overall glucose metabolism to different regions of some tumors. Such tumorheterogeneity would not be not detectable in FDG-PET.

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