Redundant roles of EGFR ligands in the ERK activation waves during collective cell migration

Mayor R, Etienne-Manneville S (2016) The front and rear of collective cell

migration. Nat Rev Mol Cell Biol 17: 97–109. doi:10.1038/nrm.2015.14

Aikin TJ, Peterson AF, Pokrass MJ, Clark HR, Regot S (2020) MAPK activity

dynamics regulate non-cell autonomous effects of oncogene

expression. Elife 9: e60541. doi:10.7554/eLife.60541

Aoki K, Kondo Y, Naoki H, Hiratsuka T, Itoh RE, Matsuda M (2017) Propagating

wave of ERK activation orients collective cell migration. Dev Cell 43:

305–317.e5. doi:10.1016/j.devcel.2017.10.016

Aoki K, Kumagai Y, Sakurai A, Komatsu N, Fujita Y, Shionyu C, Matsuda M (2013)

Stochastic ERK activation induced by noise and cell-to-cell

propagation regulates cell density-dependent proliferation. Mol Cell

52: 529–540. doi:10.1016/j.molcel.2013.09.015

Aoki K, Matsuda M (2009) Visualization of small GTPase activity with

fluorescence resonance energy transfer-based biosensors. Nat

Protoc 4: 1623–1631. doi:10.1038/nprot.2009.175

Aoki K, Yamada M, Kunida K, Yasuda S, Matsuda M (2011) Processive

phosphorylation of ERK MAP kinase in mammalian cells. Proc Natl

Acad Sci U S A 108: 12675–12680. doi:10.1073/pnas.1104030108

Boocock D, Hino N, Ruzickova N, Hirashima T, Hannezo E (2021) Theory of

mechanochemical patterning and optimal migration in cell

monolayers. Nat Phys 17: 267–274. doi:10.1038/s41567-020-01037-7

Das T, Safferling K, Rausch S, Grabe N, Boehm H, Spatz JP (2015) A molecular

mechanotransduction pathway regulates collective migration of

epithelial cells. Nat Cell Biol 17: 276–287. doi:10.1038/ncb3115

Draper BK, Komurasaki T, Davidson MK, Nanney LB (2003) Epiregulin is more

potent than EGF or TGFalpha in promoting in vitro wound closure due

to enhanced ERK/MAPK activation. J Cell Biochem 89: 1126–1137.

doi:10.1002/jcb.10584

Naito Y, Hino K, Bono H, Ui-Tei K (2015) CRISPRdirect: Software for designing

CRISPR/Cas guide RNA with reduced off-target sites. Bioinformatics

31: 1120–1123. doi:10.1093/bioinformatics/btu743

Nanba D, Toki F, Barrandon Y, Higashiyama S (2013) Recent advances in the

epidermal growth factor receptor/ligand system biology on skin

homeostasis and keratinocyte stem cell regulation. J Dermatol Sci 72:

81–86. doi:10.1016/j.jdermsci.2013.05.009

Ponsioen B, Post JB, Buissant des Amorie JR, Laskaris D, van Ineveld RL,

Kersten S, Bertotti A, Sassi F, Sipieter F, Cappe B, et al (2021)

Quantifying single-cell ERK dynamics in colorectal cancer organoids

reveals EGFR as an amplifier of oncogenic MAPK pathway signalling.

Nat Cell Biol 23: 377–390. doi:10.1038/s41556-021-00654-5

Prince RN, Schreiter ER, Zou P, Wiley HS, Ting AY, Lee RT, Lauffenburger DA

(2010) The heparin-binding domain of HB-EGF mediates localization

to sites of cell-cell contact and prevents HB-EGF proteolytic release. J

Cell Sci 123: 2308–2318. doi:10.1242/jcs.058321

Reffay M, Parrini MC, Cochet-Escartin O, Ladoux B, Buguin A, Coscoy S,

Amblard F, Camonis J, Silberzan P (2014) Interplay of RhoA and

mechanical forces in collective cell migration driven by leader cells.

Nat Cell Biol 16: 217–223. doi:10.1038/ncb2917

Riese DJ 2nd, Cullum RL (2014) Epiregulin: Roles in normal physiology and

cancer. Semin Cell Dev Biol 28: 49–56. doi:10.1016/j.semcdb.2014.03.005

Schindelin J, Arganda-Carreras I, Frise E, Kaynig V, Longair M, Pietzsch T,

Preibisch S, Rueden C, Saalfeld S, Schmid B, et al (2012) Fiji: An opensource platform for biological-image analysis. Nat Methods 9:

676–682. doi:10.1038/nmeth.2019

Dukes JD, Whitley P, Chalmers AD (2011) The MDCK variety pack: Choosing the

right strain. BMC Cell Biol 12: 43. doi:10.1186/1471-2121-12-43

Schneider MR, Werner S, Paus R, Wolf E (2008) Beyond wavy hairs: The

epidermal growth factor receptor and its ligands in skin biology and

pathology. Am J Pathol 173: 14–24. doi:10.2353/ajpath.2008.070942

Roles of EGFR ligands in the ERK waves

https://doi.org/10.26508/lsa.202101206

Lin et al.

vol 5 | no 1 | e202101206

12 of 13

A Self-archived copy in

Kyoto University Research Information Repository

https://repository.kulib.kyoto-u.ac.jp

Shukla P, Vogl C, Wallner B, Rigler D, Müller M, Macho-Maschler S (2015) Highthroughput mRNA and miRNA profiling of epithelial-mesenchymal

transition in MDCK cells. BMC genomics 16: 944. doi:10.1186/s12864015-2036-9

Singh B, Carpenter G, Coffey RJ (2016) EGF receptor ligands: Recent advances.

F1000Res 5: F1000. doi:10.12688/f1000research.9025.1

Singh B, Coffey RJ (2014) From wavy hair to naked proteins: The role of

transforming growth factor alpha in health and disease. Semin Cell

Dev Biol 28: 12–21. doi:10.1016/j.semcdb.2014.03.003

Sumiyama K, Kawakami K, Yagita K (2010) A simple and highly efficient

transgenesis method in mice with the Tol2 transposon system and

cytoplasmic microinjection. Genomics 95: 306–311. doi:10.1016/

j.ygeno.2010.02.006

Sunnarborg SW, Hinkle CL, Stevenson M, Russell WE, Raska CS, Peschon JJ,

Castner BJ, Gerhart MJ, Paxton RJ, Black RA, et al (2002) Tumor necrosis

factor-alpha converting enzyme (TACE) regulates epidermal growth

factor receptor ligand availability. J Biol Chem 277: 12838–12845.

doi:10.1074/jbc.M112050200

Sveen K (2004) An introduction to MatPIV 1.6.1. Mechanics and Applied

Mathematics http://urn.nb.no/URN:NBN:no-23418

Takazaki R, Shishido Y, Iwamoto R, Mekada E (2004) Suppression of the

biological activities of the epidermal growth factor (EGF)-like domain

by the heparin-binding domain of heparin-binding EGF-like growth

factor. J Biol Chem 279: 47335–47343. doi:10.1074/jbc.M408556200

Roles of EGFR ligands in the ERK waves

Lin et al.

Taylor SR, Markesbery MG, Harding PA (2014) Heparin-binding epidermal

growth factor-like growth factor (HB-EGF) and proteolytic processing

by a disintegrin and metalloproteinases (ADAM): A regulator of

several pathways. Semin Cell Dev Biol 28: 22–30. doi:10.1016/

j.semcdb.2014.03.004

Tinevez JY, Perry N, Schindelin J, Hoopes GM, Reynolds GD, Laplantine E,

Bednarek SY, Shorte SL, Eliceiri KW (2017) TrackMate: An open and

extensible platform for single-particle tracking. Methods 115: 80–90.

doi:10.1016/j.ymeth.2016.09.016

Wilson KJ, Gilmore JL, Foley J, Lemmon MA, Riese DJ 2nd (2009) Functional

selectivity of EGF family peptide growth factors: Implications for

cancer. Pharmacol Ther 122: 1–8. doi:10.1016/j.pharmthera.2008.11.008

Yarden Y, Sliwkowski MX (2001) Untangling the ErbB signalling network. Nat

Rev Mol Cell Biol 2: 127–137. doi:10.1038/35052073

Yusa K, Rad R, Takeda J, Bradley A (2009) Generation of transgene-free

induced pluripotent mouse stem cells by the piggyBac transposon.

Nat Methods 6: 363–369. doi:10.1038/nmeth.1323

Zeng F, Harris RC (2014) Epidermal growth factor, from gene organization to

bedside. Semin Cell Dev Biol 28: 2–11. doi:10.1016/j.semcdb.2014.01.011

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