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Author contributions

L.C., M.T., A.Y., Y.N., F.T., and S.D. performed mouse administration experiments. L.C. and M.T. performed

LC-qTOF/MS analysis. L.C., M.T., F.T., S.D., and T.M. analyzed and discussed the results and designed the

experimental strategy. L.C. and M.T. wrote the manuscript. T.M. designed the study, revised the manuscript, and

supervised the project. All authors have read and approved the final manuscript for publication.

Funding

This work was partly supported by JSPS KAKENHI [grant numbers JP21H04863 (T.M.) and JP21F21386 (T.M.

and L.C.)].

Competing interests The authors declare no competing interests.

Additional information

Supplementary Information The online version contains supplementary material available at https://​doi.​org/​

10.​1038/​s41598-​023-​44161-z.

Correspondence and requests for materials should be addressed to T.M.

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