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非感染性ぶどう膜炎に対する新規治療標的の検討

鈴木, 佳代 北海道大学

2023.06.30

概要

非感染性ぶどう膜炎の治療には, 主としてステロイド薬, 免疫抑制薬など
が用いられてきた. 近年, 本邦では難治例には tumor necrosis factor (TNF)阻
害薬が使用される. しかしながら, これらの治療薬でも重篤な視力障害に
陥る症例がみられ, 新薬の開発が今も強く望まれている. そこで新たな治
療標的として, 第 1 章では angiopoietin(Ang)2 と vascular endothelial growth
factor(VEGF)A に, 第 2 章では plasminogen activator inhibitor(PAI)-1 に着目し
た.
第 1 章: 非感染性ぶどう膜炎における Ang2 と VEGFA の炎症への関与の検

【背景と目的】Ang2 は, 様々な炎症刺激により血管内皮細胞から分泌され,
発現が豊富になると, Ang1 の tyrosine kinase with immunoglobulin and EGF
homology domain(Tie)2 受容体への結合が競合的に阻害され, 結果として内
皮細胞上の白血球接着分子が増加することが報告されている. 一方, VEGFA
には, Ang2 の細胞外への分泌を促進させる働きがあることが知られている.
本研究では Ang2 と VEGFA の眼炎症病態への関与を検討することを目的と
した.
【対象と方法】特発性ぶどう膜炎患者 16 名(ぶどう膜炎群), 非炎症性眼疾
患患者 16 名(対照群)を対象として, 硝子体液中の Ang1, Ang2, VEGFA のタ
ンパク濃度を測定した. また, 実験的自己免疫性ぶどう膜網膜炎(EAU)マウ
スを用いた検討では, B10.BR マウスにヒト網膜視細胞間レチノイド結合蛋
白由来ペプチド(K2 ペプチド)と complete Freund’s adjuvant の懸濁液を皮下
に免疫し, EAU を惹起した. 免疫後, 11, 16, 21 日目のマウスから網脈絡膜を
摘出し, Ang1, Ang2 と VEGFA の mRNA 発現を測定し, K2 ペプチドを除いて
免疫した対照群と比較した. また, EAU マウスに対して, それぞれ抗 Ang2
抗 体 , 抗 VEGFA 抗 体 , 抗 Ang2 抗 体 と 抗 VEGFA 抗 体 の 同 時 投 与 , 抗
Ang2/VEGFA 二重特異性抗体, そして非特異的抗体(対照)を免疫の前日から
5 日毎に計 5 回投与した群を作製し, 臨床的重症度を経時的(3-4 日毎)に観
察し, 21 日目に眼球を摘出して病理組織学的重症度を評価した.
【結果】硝子体液中の Ang1, Ang2, VEGFA のタンパク濃度はぶどう膜炎群
において対照群と比べ, 有意に高値を示した(p<0.05). また, Ang1 と Ang2 の
タ ン パ ク 濃 度 を 比 べ る と , ぶ ど う 膜 炎 群 で Ang2 が 有 意 に 高 値 で あ っ た
(p<0.05). ...

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参考文献

Akwii RG, Sajib MS, Zahra FT, Mikelis CM (2019) Role of Angiopoietin-2 in

Vascular Physiology and Pathophysiology. Cells 8

Bertelmann T, Spychalska M, Kohlberger L, Strodthoff S, Witteborn M, Kicova N,

Sachs U, Irle S, Mennel S (2013) Intracameral concentrations of the fibrinolytic

system components in patients with age-related macular degeneration. Graefes

Arch Clin Exp Ophthalmol 251: 2697-2704

Cabral T, Lima LH, Mello LGM, Polido J, Correa É, Oshima A, Duong J,

Serracarbassa P, Regatieri CV, Mahajan VB et al (2018) Bevacizumab Injection in

Patients with Neovascular Age-Related Macular Degeneration Increases

Angiogenic Biomarkers. Ophthalmol Retina 2: 31-37

Cao C, Lawrence DA, Li Y, Von Arnim CA, Herz J, Su EJ, Makarova A, Hyman

BT, Strickland DK, Zhang L (2006) Endocytic receptor LRP together with tPA and

PAI-1 coordinates Mac-1-dependent macrophage migration. EMBO J 25: 18601870

Caspi RR, Roberge FG, Chan CC, Wiggert B, Chader GJ, Rozenszajn LA, Lando

Z, Nussenblatt RB (1988) A new model of autoimmune disease. Experimental

autoimmune uveoretinitis induced in mice with two different retinal antigens. J

Immunol 140: 1490-1495

Chan CC, Mochizuki M, Palestine AG, BenEzra D, Gery I, Nussenblatt RB (1985)

Kinetics of T-lymphocyte subsets in the eyes of Lewis rats with experimental

autoimmune uveitis. Cell Immunol 96: 430-434

Chi YF, Chai JK, Yu YM, Luo HM, Zhang QX, Feng R (2015) Association

between PAI-1 polymorphisms and plasma PAI-1 level with sepsis in severely

burned patients. Genet Mol Res 14: 10081-10086

Choe JY, Park SH, Kim SK (2010) Serum angiopoietin-1 level is increased in

patients with Behçet's disease. Joint Bone Spine 77: 340-344

Cravens PD, Lipsky PE (2002) Dendritic cells, chemokine receptors and

autoimmune inflammatory diseases. Immunol Cell Biol 80: 497-505

Davis S, Aldrich TH, Jones PF, Acheson A, Compton DL, Jain V, Ryan TE, Bruno

J, Radziejewski C, Maisonpierre PC et al (1996) Isolation of angiopoietin-1, a

ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell 87: 11611169

De Kozak Y, FRE, Usui M, Faure JP (1976) [Experimental autoimmune

47

uveoretinitis. Ultrastructure of chorioretinal lesions induced in guinea pigs by

immunization against the outer rods of the bovine retina]. Arch Ophtalmol (Paris)

36: 231-248

de Sá MC, Simão ANC, de Medeiros FA, Iriyoda TMV, Costa NT, Alfieri DF,

Flauzino T, Sekiguchi BA, Lozovoy MAB, Reiche EMV et al (2018) Cell

adhesion molecules and plasminogen activator inhibitor type-1 (PAI-1) in patients

with rheumatoid arthritis: influence of metabolic syndrome. Clin Exp Med 18:

495-504

De Taeye B, Smith LH, Vaughan DE (2005) Plasminogen activator inhibitor-1: a

common denominator in obesity, diabetes and cardiovascular disease. Curr Opin

Pharmacol 5: 149-154

Degryse B, Neels JG, Czekay RP, Aertgeerts K, Kamikubo Y, Loskutoff DJ (2004)

The low density lipoprotein receptor-related protein is a motogenic receptor for

plasminogen activator inhibitor-1. J Biol Chem 279: 22595-22604

Dick AD, Forrester JV, Liversidge J, Cope AP (2004) The role of tumour necrosis

factor (TNF-alpha) in experimental autoimmune uveoretinitis (EAU). Prog Retin

Eye Res 23: 617-637

Dong Z, Iwata D, Kitaichi N, Takeuchi M, Sato M, Endo N, Iwabuchi K, Ando R,

Fukuhara J, Kinoshita S et al (2014) Amelioration of experimental autoimmune

uveoretinitis by inhibition of glyceraldehyde-derived advanced glycation endproduct formation. J Leukoc Biol 96: 1077-1085

East E, Gverić D, Baker D, Pryce G, Lijnen HR, Cuzner ML (2008) Chronic

relapsing experimental allergic encephalomyelitis (CREAE) in plasminogen

activator inhibitor-1 knockout mice: the effect of fibrinolysis during

neuroinflammation. Neuropathol Appl Neurobiol 34: 216-230

Fearon U, Griosios K, Fraser A, Reece R, Emery P, Jones PF, Veale DJ (2003)

Angiopoietins, growth factors, and vascular morphology in early arthritis. J

Rheumatol 30: 260-268

Felcht M, Luck R, Schering A, Seidel P, Srivastava K, Hu J, Bartol A, Kienast Y,

Vettel C, Loos EK et al (2012) Angiopoietin-2 differentially regulates

angiogenesis through TIE2 and integrin signaling. J Clin Invest 122: 1991-2005

Fiedler U, Reiss Y, Scharpfenecker M, Grunow V, Koidl S, Thurston G, Gale NW,

Witzenrath M, Rosseau S, Suttorp N et al (2006) Angiopoietin-2 sensitizes

endothelial cells to TNF-alpha and has a crucial role in the induction of

inflammation. Nat Med 12: 235-239

48

Fiedler U, Scharpfenecker M, Koidl S, Hegen A, Grunow V, Schmidt JM, Kriz W,

Thurston G, Augustin HG (2004) The Tie-2 ligand angiopoietin-2 is stored in and

rapidly released upon stimulation from endothelial cell Weibel-Palade bodies.

Blood 103: 4150-4156

Gale NW, Thurston G, Hackett SF, Renard R, Wang Q, McClain J, Martin C, Witte

C, Witte MH, Jackson D et al (2002) Angiopoietin-2 is required for postnatal

angiogenesis and lymphatic patterning, and only the latter role is rescued by

Angiopoietin-1. Dev Cell 3: 411-423

Glimcher LH, Kim KJ, Green I, Paul WE (1982) Ia antigen-bearing B cell tumor

lines can present protein antigen and alloantigen in a major histocompatibility

complex-restricted fashion to antigen-reactive T cells. J Exp Med 155: 445-459

Gupta KK, Xu Z, Castellino FJ, Ploplis VA (2016) Plasminogen activator

inhibitor-1 stimulates macrophage activation through Toll-like Receptor-4.

Biochem Biophys Res Commun 477: 503-508

Hah YS, Koh YJ, Lim HS, Kim HO, Cheon YH, Noh HS, Jang KY, Lee SY, Lee

GM, Koh GY et al (2013) Double-antiangiogenic protein DAAP targeting

vascular endothelial growth factor A and angiopoietins attenuates collageninduced arthritis. Arthritis Res Ther 15: R85

Hakanpaa L, Sipila T, Leppanen VM, Gautam P, Nurmi H, Jacquemet G, Eklund

L, Ivaska J, Alitalo K, Saharinen P (2015) Endothelial destabilization by

angiopoietin-2 via integrin β1 activation. Nat Commun 6: 5962

Hammes HP, Lin J, Wagner P, Feng Y, Vom Hagen F, Krzizok T, Renner O, Breier

G, Brownlee M, Deutsch U (2004) Angiopoietin-2 causes pericyte dropout in the

normal retina: evidence for involvement in diabetic retinopathy. Diabetes 53:

1104-1110

Hanahan D (1997) Signaling vascular morphogenesis and maintenance. Science

277: 48-50

Heil M, Clauss M, Suzuki K, Buschmann IR, Willuweit A, Fischer S, Schaper W

(2000) Vascular endothelial growth factor (VEGF) stimulates monocyte migration

through endothelial monolayers via increased integrin expression. Eur J Cell Biol

79: 850-857

Hughes DP, Marron MB, Brindle NP (2003) The antiinflammatory endothelial

tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN2. Circ Res 92: 630-636

Ichimura A, Matsumoto S, Suzuki S, Dan T, Yamaki S, Sato Y, Kiyomoto H, Ishii

49

N, Okada K, Matsuo O et al (2013) A small molecule inhibitor to plasminogen

activator inhibitor 1 inhibits macrophage migration. Arterioscler Thromb Vasc

Biol 33: 935-942

Imhof BA, Aurrand-Lions M (2006) Angiogenesis and inflammation face off. Nat

Med 12: 171-172

Iurlaro M, Scatena M, Zhu WH, Fogel E, Wieting SL, Nicosia RF (2003) Rat

aorta-derived mural precursor cells express the Tie2 receptor and respond directly

to stimulation by angiopoietins. J Cell Sci 116: 3635-3643

Iwata D, Kitaichi N, Miyazaki A, Iwabuchi K, Yoshida K, Namba K, Ozaki M,

Ohno S, Umezawa K, Yamashita K et al (2010) Amelioration of experimental

autoimmune uveoretinitis with nuclear factor-{kappa}B Inhibitor dehydroxy

methyl epoxyquinomicin in mice. Invest Ophthalmol Vis Sci 51: 2077-2084

Iwata D, Mizuuchi K, Aoki K, Horie Y, Kase S, Namba K, Ohno S, Ishida S,

Kitaichi N (2017) Serial Frequencies and Clinical Features of Uveitis in

Hokkaido, Japan. Ocul Immunol Inflamm 25: S15-S18

Jeltsch M, Leppänen VM, Saharinen P, Alitalo K (2013) Receptor tyrosine kinasemediated angiogenesis. Cold Spring Harb Perspect Biol 5

Jeon H, Kim JH, Lee WH, Lee MS, Suk K (2012) Plasminogen activator inhibitor

type 1 regulates microglial motility and phagocytic activity. J Neuroinflammation

9: 149

Kase S, Namba K, Kanno-Okada H, Onozawa M, Hidaka D, Iwata D, Mizuuchi K,

Fukuhara T, Fukuhara J, Kitaichi N et al (2020) Immunohistochemical and

Immunocytochemical Analyses in Patients with Vitreoretinal Lymphoma. Ocul

Immunol Inflamm 28: 147-155

Khanani AM, Patel SS, Ferrone PJ, Osborne A, Sahni J, Grzeschik S, Basu K,

Ehrlich JS, Haskova Z, Dugel PU (2020) Efficacy of Every Four Monthly and

Quarterly Dosing of Faricimab vs Ranibizumab in Neovascular Age-Related

Macular Degeneration: The STAIRWAY Phase 2 Randomized Clinical Trial.

JAMA Ophthalmol 138: 964-972

Kim HB (1997) Ophthalmologic manifestation of Behçet's disease. Yonsei Med J

38: 390-394

Kitamei H, Kitaichi N, Namba K, Kotake S, Goda C, Kitamura M, Miyazaki A,

Ohno S (2009) Clinical features of intraocular inflammation in Hokkaido, Japan.

Acta Ophthalmol 87: 424-428

Kitamura M, Iwabuchi K, Kitaichi N, Kon S, Kitamei H, Namba K, Yoshida K,

50

Denhardt DT, Rittling SR, Ohno S et al (2007) Osteopontin aggravates

experimental autoimmune uveoretinitis in mice. J Immunol 178: 6567-6572

Koch S, Claesson-Welsh L (2012) Signal transduction by vascular endothelial

growth factor receptors. Cold Spring Harb Perspect Med 2: a006502

Lebas H, Guérit S, Picot A, Boulay AC, Fournier A, Vivien D, Cohen Salmon M,

Docagne F, Bardou I (2022) PAI-1 production by reactive astrocytes drives tissue

dysfibrinolysis in multiple sclerosis models. Cell Mol Life Sci 79: 323

Lee J, Park DY, Park I, Chang W, Nakaoka Y, Komuro I, Yoo OJ, Koh GY (2014)

Angiopoietin-1 suppresses choroidal neovascularization and vascular leakage.

Invest Ophthalmol Vis Sci 55: 2191-2199

Li Z, Korhonen EA, Merlini A, Strauss J, Wihuri E, Nurmi H, Antila S, Paech J,

Deutsch U, Engelhardt B et al (2020) Angiopoietin-2 blockade ameliorates

autoimmune neuroinflammation by inhibiting leukocyte recruitment into the CNS.

J Clin Invest 130: 1977-1990

Luna JD, Chan CC, Derevjanik NL, Mahlow J, Chiu C, Peng B, Tobe T,

Campochiaro PA, Vinores SA (1997) Blood-retinal barrier (BRB) breakdown in

experimental autoimmune uveoretinitis: comparison with vascular endothelial

growth factor, tumor necrosis factor alpha, and interleukin-1beta-mediated

breakdown. J Neurosci Res 49: 268-280

Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C,

Compton D, McClain J, Aldrich TH, Papadopoulos N et al (1997) Angiopoietin-2,

a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 277: 5560

McAdam AJ, Schweitzer AN, Sharpe AH (1998) The role of B7 co-stimulation in

activation and differentiation of CD4+ and CD8+ T cells. Immunol Rev 165: 231247

Murakami M, Iwai S, Hiratsuka S, Yamauchi M, Nakamura K, Iwakura Y, Shibuya

M (2006) Signaling of vascular endothelial growth factor receptor-1 tyrosine

kinase promotes rheumatoid arthritis through activation of

monocytes/macrophages. Blood 108: 1849-1856

Nakatsuka E, Sawada K, Nakamura K, Yoshimura A, Kinose Y, Kodama M,

Hashimoto K, Mabuchi S, Makino H, Morii E et al (2017) Plasminogen activator

inhibitor-1 is an independent prognostic factor of ovarian cancer and IMD-4482, a

novel plasminogen activator inhibitor-1 inhibitor, inhibits ovarian cancer

peritoneal dissemination. Oncotarget 8: 89887-89902

51

Namba K, Ogasawara K, Kitaichi N, Matsuki N, Takahashi A, Sasamoto Y, Kotake

S, Matsuda H, Iwabuchi K, Ohno S et al (1998) Identification of a peptide

inducing experimental autoimmune uveoretinitis (EAU) in H-2Ak-carrying mice.

Clin Exp Immunol 111: 442-449

Namba K, Ogasawara K, Kitaichi N, Morohashi T, Sasamoto Y, Kotake S,

Matsuda H, Iwabuchi K, Iwabuchi C, Ohno S et al (2000) Amelioration of

experimental autoimmune uveoretinitis by pretreatment with a pathogenic peptide

in liposome and anti-CD40 ligand monoclonal antibody. J Immunol 165: 29622969

Ng DS, Yip YW, Bakthavatsalam M, Chen LJ, Ng TK, Lai TY, Pang CP, Brelén

ME (2017) Elevated angiopoietin 2 in aqueous of patients with neovascular age

related macular degeneration correlates with disease severity at presentation. Sci

Rep 7: 45081

Nussenblatt RB, Kuwabara T, de Monasterio FM, Wacker WB (1981) S-antigen

uveitis in primates. A new model for human disease. Arch Ophthalmol 99: 10901092

Ohta K, Yamagami S, Wiggert B, Dana MR, Streilein JW (2002) Chemokine gene

expression in iris-ciliary body during experimental autoimmune uveoretinitis.

Curr Eye Res 24: 451-457

Okada AA, Goto H, Ohno S, Mochizuki M, Japan OBsDRGO (2012) Multicenter

study of infliximab for refractory uveoretinitis in Behçet disease. Arch

Ophthalmol 130: 592-598

Oshima Y, Oshima S, Nambu H, Kachi S, Hackett SF, Melia M, Kaleko M,

Connelly S, Esumi N, Zack DJ et al (2004) Increased expression of VEGF in

retinal pigmented epithelial cells is not sufficient to cause choroidal

neovascularization. J Cell Physiol 201: 393-400

Oztürk MA, Ertenli I, Kiraz S, C

Haznedaroğlu I, Celik I, Kirazli S, Calgüneri

M (2004) Plasminogen activator inhibitor-1 as a link between pathological

fibrinolysis and arthritis of Behçet's disease. Rheumatol Int 24: 98-102

Park HJ, Chi GY, Choi YH, Park SH (2020) Lupeol suppresses plasminogen

activator inhibitor-1-mediated macrophage recruitment and attenuates M2

macrophage polarization. Biochem Biophys Res Commun 527: 889-895

Pelisch N, Dan T, Ichimura A, Sekiguchi H, Vaughan DE, van Ypersele de Strihou

C, Miyata T (2015) Plasminogen Activator Inhibitor-1 Antagonist TM5484

Attenuates Demyelination and Axonal Degeneration in a Mice Model of Multiple

52

Sclerosis. PLoS One 10: e0124510

Peters S, Cree IA, Alexander R, Turowski P, Ockrim Z, Patel J, Boyd SR, Joussen

AM, Ziemssen F, Hykin PG et al (2007) Angiopoietin modulation of vascular

endothelial growth factor: Effects on retinal endothelial cell permeability.

Cytokine 40: 144-150

Qin Y, Zhang J, Babapoor-Farrokhran S, Applewhite B, Deshpande M, Megarity

H, Flores-Bellver M, Aparicio-Domingo S, Ma T, Rui Y et al (2022) PAI-1 is a

vascular cell-specific HIF-2-dependent angiogenic factor that promotes retinal

neovascularization in diabetic patients. Sci Adv 8: eabm1896

Rabieian R, Boshtam M, Zareei M, Kouhpayeh S, Masoudifar A, Mirzaei H

(2018) Plasminogen Activator Inhibitor Type-1 as a Regulator of Fibrosis. J Cell

Biochem 119: 17-27

Regula JT, Lundh von Leithner P, Foxton R, Barathi VA, Cheung CM, Bo Tun SB,

Wey YS, Iwata D, Dostalek M, Moelleken J et al (2016) Targeting key angiogenic

pathways with a bispecific CrossMAb optimized for neovascular eye diseases.

EMBO Mol Med 8: 1265-1288

Reiss Y, Droste J, Heil M, Tribulova S, Schmidt MHH, Schaper W, Dumont DJ,

Plate KH (2007) Angiopoietin-2 impairs revascularization after limb ischemia.

Circ Res 101: 88-96

Saharinen P, Eklund L, Alitalo K (2017) Therapeutic targeting of the angiopoietinTIE pathway. Nat Rev Drug Discov 16: 635-661

Sahni J, Patel SS, Dugel PU, Khanani AM, Jhaveri CD, Wykoff CC, Hershberger

VS, Pauly-Evers M, Sadikhov S, Szczesny P et al (2019) Simultaneous Inhibition

of Angiopoietin-2 and Vascular Endothelial Growth Factor-A with Faricimab in

Diabetic Macular Edema: BOULEVARD Phase 2 Randomized Trial.

Ophthalmology 126: 1155-1170

Sato T, Shima C, Kusaka S (2011) Vitreous levels of angiopoietin-1 and

angiopoietin-2 in eyes with retinopathy of prematurity. Am J Ophthalmol 151:

353-357.e351

Scholz A, Plate KH, Reiss Y (2015) Angiopoietin-2: a multifaceted cytokine that

functions in both angiogenesis and inflammation. Ann N Y Acad Sci 1347: 45-51

Schonthaler HB, Huggenberger R, Wculek SK, Detmar M, Wagner EF (2009)

Systemic anti-VEGF treatment strongly reduces skin inflammation in a mouse

model of psoriasis. Proc Natl Acad Sci U S A 106: 21264-21269

Shibuya M (2015) VEGF-VEGFR System as a Target for Suppressing

53

Inflammation and other Diseases. Endocr Metab Immune Disord Drug Targets 15:

135-144

Shinagawa M, Namba K, Mizuuchi K, Iwata D, Hase K, Suzuki K, Hirooka K,

Kitaichi N, Hiraoka M, Ishida S (2022) The Steroid-Sparing Effect of

Adalimumab in the Treatment for the Recurrent Phase of Vogt-Koyanagi-Harada

Disease. Ocul Immunol Inflamm: 1-5

Sillen M, Declerck PJ (2021) A Narrative Review on Plasminogen Activator

Inhibitor-1 and Its (Patho)Physiological Role: To Target or Not to Target? Int J

Mol Sci 22

Sonoda KH, Hasegawa E, Namba K, Okada AA, Ohguro N, Goto H, Group

JJOISUSW (2021) Epidemiology of uveitis in Japan: a 2016 retrospective

nationwide survey. Jpn J Ophthalmol 65: 184-190

Sundberg C, Kowanetz M, Brown LF, Detmar M, Dvorak HF (2002) Stable

expression of angiopoietin-1 and other markers by cultured pericytes: phenotypic

similarities to a subpopulation of cells in maturing vessels during later stages of

angiogenesis in vivo. Lab Invest 82: 387-401

Suzuki K, Ishihara M, Namba K, Ohno S, Goto H, Takase H, Kawano S, Shibuya

E, Hase K, Iwata D et al (2022) Clinical features of ocular sarcoidosis: severe,

refractory, and prolonged inflammation. Jpn J Ophthalmol

Takakura N, Watanabe T, Suenobu S, Yamada Y, Noda T, Ito Y, Satake M, Suda T

(2000) A role for hematopoietic stem cells in promoting angiogenesis. Cell 102:

199-209

Takeuchi M, Kezuka T, Sugita S, Keino H, Namba K, Kaburaki T, Maruyama K,

Nakai K, Hijioka K, Shibuya E et al (2014) Evaluation of the long-term efficacy

and safety of infliximab treatment for uveitis in Behçet's disease: a multicenter

study. Ophthalmology 121: 1877-1884

Thurau SR, Chan CC, Nussenblatt RB, Caspi RR (1997) Oral tolerance in a

murine model of relapsing experimental autoimmune uveoretinitis (EAU):

induction of protective tolerance in primed animals. Clin Exp Immunol 109: 370376

Tsuchiya S, Yamabe M, Yamaguchi Y, Kobayashi Y, Konno T, Tada K (1980)

Establishment and characterization of a human acute monocytic leukemia cell line

(THP-1). Int J Cancer 26: 171-176

Uemura A, Fruttiger M, D'Amore PA, De Falco S, Joussen AM, Sennlaub F,

Brunck LR, Johnson KT, Lambrou GN, Rittenhouse KD et al (2021) VEGFR1

54

signaling in retinal angiogenesis and microinflammation. Prog Retin Eye Res 84:

100954

Wacker WB, Lipton MM (1965) Experimental allergic uveitis: homologous retina

as uveitogenic antigen. Nature 206: 253-254

Watanabe D, Suzuma K, Suzuma I, Ohashi H, Ojima T, Kurimoto M, Murakami T,

Kimura T, Takagi H (2005) Vitreous levels of angiopoietin 2 and vascular

endothelial growth factor in patients with proliferative diabetic retinopathy. Am J

Ophthalmol 139: 476-481

Weiss K, Steinbrugger I, Weger M, Ardjomand N, Maier R, Wegscheider BJ,

Wedrich A, El-Shabrawi Y (2009) Intravitreal VEGF levels in uveitis patients and

treatment of uveitic macular oedema with intravitreal bevacizumab. Eye (Lond)

23: 1812-1818

Westra J, de Groot L, Plaxton SL, Brouwer E, Posthumus MD, Kallenberg CG,

Bijl M (2011) Angiopoietin-2 is highly correlated with inflammation and disease

activity in recent-onset rheumatoid arthritis and could be predictive for

cardiovascular disease. Rheumatology (Oxford) 50: 665-673

Yamamoto K, Takeshita K, Shimokawa T, Yi H, Isobe K, Loskutoff DJ, Saito H

(2002) Plasminogen activator inhibitor-1 is a major stress-regulated gene:

implications for stress-induced thrombosis in aged individuals. Proc Natl Acad Sci

U S A 99: 890-895

Yano A, Schwartz RH, Paul WE (1977) Antigen presentation in the murine Tlymphocyte proliferative response. I. Requirement for genetic identity at the major

histocompatibility complex. J Exp Med 146: 828-843

Yousef AA, Mohamed FY, Boraey NF, Akeel NE, Soliman AA, Waked NM,

Hashem MIA, Shehata H, Fahmy DS, Ismael A et al (2020) Association of

Plasminogen Activator Inhibitor 1 (PAI-1) 4G/5G Polymorphism and

Susceptibility to SLE in Egyptian Children and Adolescents: A Multicenter Study.

J Inflamm Res 13: 1103-1111

Zhang L, Yang N, Park JW, Katsaros D, Fracchioli S, Cao G, O'Brien-Jenkins A,

Randall TC, Rubin SC, Coukos G (2003) Tumor-derived vascular endothelial

growth factor up-regulates angiopoietin-2 in host endothelium and destabilizes

host vasculature, supporting angiogenesis in ovarian cancer. Cancer Res 63: 34033412

大野 重昭, 岡田 アナベルあやめ, 後藤 浩, 南場 研一, 北市 伸義, 有賀

俊英, 石原 麻美, 臼井 嘉彦, 大黒 伸行, 蕪城 俊克, 慶野 博, 杉田 直,

55

鈴木 潤, 園田 康平, 堤 雅幸, 中尾 久美子, 堀江 幸弘, 水木 信久, 八

代 成子, 横井 克俊, 日本眼炎症学会ぶどう膜炎診療ガイドライン作成

委員会. (2019) ぶどう膜炎診療ガイドライン. 日本眼科学会雑誌 123 巻 6

号 635-696

56

...

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