Biological and Synthetic Studies of Mitochondrial Respiratory Chain Inhibitors

概要

Oxidative phosphorylation (OXPHOS) is a metabolic pathway that produces ATP, and most
aerobic organisms use this function. OXPHOS is established by the conjugation of the electron
transport chain (also called respiratory chain) and chemiosmosis.1 Enzymes of the electron transport
chain consist of NADH-quinone oxidoreductase (complex I), succinate-quinone oxidoreductase
(complex II), quinol-cytochrome c oxidoreductase (complex III), and cytochrome c oxidase (complex
IV) (Figure 1). These enzymes transfer electrons from NADH or succinate to a final electron acceptor
molecular oxygen, which is coupled to proton translocation through the membrane. FoF1-ATP synthase
(also called complex V) uses the proton gradient formed across the membrane to generate ATP from
ADP and inorganic phosphate. In eukaryotic cells, OXPHOS is carried out by the respiratory enzymes
embedded in the inner membrane of mitochondria. ...

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