[1] Pampaloni F, Reynaud EG, Stelzer EHK. The third dimension bridges the gap
between cell culture and live tissue. Nat Rev Mol Cell Biol 2007;8:839e45.
[2] Griffith GL, Swartz AM. Capturing complex 3D tissue physiology in vitro. Nat
Rev Mol Cell Biol 2006;7:211e24.
[3] Baharvand H, Hashemi SM, Ashtiani SK, Farrokhi A. Differentiation of human
embryonic stem cells into hepatocytes in 2D and 3D culture systems in vitro.
Int J Dev Biol 2006;50:645e52.
[4] Hirschhaeuser F, Menne H, Dittfeld C, West J, Mueller-Klieser W, KunzSchughart LA. Multicellular tumor spheroids: an underestimated tool is
catching up again. J Biotechnol 2010;148:3e15.
[5] Pickl M, Ries CH. Comparison of 3D and 2D tumor models reveals enhanced
HER2 activation in 3D associated with an increased response to trastuzumab.
Oncogene 2009;28:461e8.
[6] Tung YC, Hsiao AY, Allen SG, Torisawa Y, Hoc M, Takayama S. High-throughput
3D spheroid culture and drug testing using a 384 hanging drop array. Analyst
2011;136:473e8.
[7] Imamura Y, Mukohara T, Shimono Y, Funakoshi Y, Chayahara N, Toyoda M,
et al. Comparison of 2D- and 3D-culture models as drug-testing platforms in
blest cancer. Oncol Rep 2015;33:1837e43.
[8] Memon AI, Sawa Y, Fukushima N, Matsumiya G, Miyagawa S, Taketani S, et al.
Repair of impaired myocardium by means of implantation of engineered
autologous myoblast sheets. J Thorac Cardiovasc Surg 2005;130:1333e41.
[9] Karageorgiou V, Kaplan D. Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials 2005;26:5474e91.
[10] Zeltinger J, Sherwood J, Graham DA, Mueller R, Griffith LG. Effect of pore size
and void fraction on cellular adhesion, proliferation, and matrix deposition.
Tissue Eng 2001;7:557e72.
428
A Self-archived copy in
Kyoto University Research Information Repository
https://repository.kulib.kyoto-u.ac.jp
T. Saotome, N. Shimada, K. Matsuno et al.
Regenerative Therapy 18 (2021) 418e429
[42] Tam H, Zhang W, Feaver RK, Parchment N, Sacks SM, Vyavahara N. A novel
crosslinking method for improved tear resistance and biocompatibility of
tissue based biomaterials. Biomaterials 2015;66:83e91.
[43] Chavoshnejad P, Razavi MJ. Effect of the interfiber bonding on the mechanical
behavior of electrospun fibrous mats. Sci Rep 2020;10:7709.
[44] Chang KM, Liao HT, Chen JP. Preparation and characterization of gelatin/hyaluronic acid cryogels for adipose tissue engineering: in vitro and in vivo
studies. Acta Biomater 2013;9:9012e26.
[45] Colom A, Galgoczy R, Almendros I, Xaubet A, Farr R. Oxygen diffusion and
consumption in extracellular matrix gels: implications for designing threedimensional cultures. J Biomed Mater Res A 2014;102A:2776e84.
[46] Deschepper M, Oudina K, David B, Myrtil V, Collet C, Bensidhoum M, et al.
Survival and function of mesenchymal stem cells (MSCs) depend on glucose to
[47]
[48]
[49]
[50]
[51]
429
overcome exposure to long-term, severe and continuous hypoxia. J Cell Mol
Med 2011;15:1505e14.
Zhu W, Chen J, Cong X, Hu S, Che X. Hypoxia and serum deprivation-induced
apoptosis in mesenchymal stem cells. Stem Cell 2006;24:416e25.
Bonnans C, Chou J, Werb Z. Remodelling the extracellular matrix in development and disease. Nat Rev Mol Cell Biol 2014;15:786e801.
Vlierberghe SV, Vanderleyden E, Dubruel P, Vos FD, Schacht E. Affinity study
of novel gelatin cell carriers for fibronectin. Macromol Biosci 2009;9:
1105e15.
Engvall E, Ruoslahti E. Binding of soluble form of fibroblast surface protein,
fibronectin, to collagen. Int J Cancer 1977;20:1e5.
Breslin S, O'Driscoll L. Three-dimensional cell culture: the missing link in drug
discovery. Drug Discov Today 2013;18:240e9.
...